Search Results - "ZHANG, Ji Y"

Development and validation of a liquid chromatography–tandem mass spectrometric assay for Eplerenone and its hydrolyzed metabolite in human plasma by Zhang, Ji Y., Fast, Douglas M., Breau, Alan P.

“…A sensitive and specific liquid chromatography–tandem mass spectrometry assay was developed to quantify the first selective aldosterone blocker Eplerenone (I)…”
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Disposition of a Specific Cyclooxygenase-2 Inhibitor, Valdecoxib, in Human by Josh J. Yuan, Dai-chang Yang, Ji Y. Zhang, Roy Bible, Jr, Aziz Karim, John W. A. Findlay

“…Valdecoxib is a potent and specific inhibitor of cyclooxygenase-2, which is used for the treatment of rheumatoid arthritis, osteoarthritis, and the…”
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Determination of valdecoxib and its metabolites in human urine by automated solid-phase extraction–liquid chromatography–tandem mass spectrometry by Zhang, Ji Y., Fast, Douglas M., Breau, Alan P.

“…A simple, sensitive and specific automated SPE–LC–MS–MS assay was developed and validated for determination of valdecoxib (I), its hydroxylated metabolite (II)…”
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Pharmacokinetics and Metabolism of a COX-2 Inhibitor, Valdecoxib, in Mice by ZHANG, Ji Y, YUAN, Josh J, WANG, Yue-Fen, BIBLE, Roy H, BREAU, Alan P

“…The pharmacokinetics and metabolism of valdecoxib, a potent cyclooxygenase-2 selective inhibitor, were investigated in mice. Valdecoxib was extensively…”
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Involvement of Human UGT2B7 and 2B15 in Rofecoxib Metabolism by ZHANG, Ji Y, ZHAN, Jenny, COOK, Chyung S, INGS, Robert M, BREAU, Alan P

“…O -Glucuronidation of 5-hydroxyrofecoxib is the major biotransformation pathway of rofecoxib in human, rat, and dog. The glucuronide conjugate is also involved…”
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Xenobiotic-metabolizing enzymes in human lung by Zhang, Ji Y, Wang, Yuefen, Prakash, Chandra

“…Human lung is a major target organ for all inhaled drugs, environmental toxicants and carcinogens. Recent hypotheses suggesting a role for environmental…”
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Characterization of metabolites of Celecoxib in rabbits by liquid chromatography/tandem mass spectrometry by Zhang, Ji Y., Wang, YueFen, Dudkowski, Caroline, Yang, Dai-chang, Chang, Ming, Yuan, Jinhua, Paulson, Susan K., Breau, Alan P.

“…The metabolism of the anti‐inflammatory drug Celecoxib in rabbits was characterized using liquid chromatography (LC)/tandem mass spectrometry (MS/MS) with…”
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Pharmacokinetics, Tissue Distribution, Metabolism, and Excretion of Celecoxib in Rats by PAULSON, S. K, ZHANG, J. Y, MAZIASZ, T. J, SCHOENHARD, G. L, BURTON, E. G, BREAU, A. P, HRIBAR, J. D, LIU, N. W. K, JESSEN, S. M, LAWAL, Y. M, COGBURN, J. N, GRESK, C. J, MARKOS, C. S

“…The pharmacokinetics, tissue distribution, metabolism, and excretion of celecoxib, 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1 H -pyrazol-1-yl]…”
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Development and validation of an automated SPE-LC-MS/MS assay for valdecoxib and its hydroxylated metabolite in human plasma by Zhang, Ji Y, Fast, Douglas M, Breau, Alan P

“…A sensitive and specific liquid chromatography-tandem mass spectrometry assay was developed to quantitate valdecoxib (I) and its hydroxylated metabolite (II)…”
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Collision-induced dissociation of valdecoxib metabolites: a novel rearrangement involving an isoxazole ring by Zhang, Ji Y., Xu, Fran, Breau, Alan P.

“…Valdecoxib is a potent COX‐2 inhibitor. During metabolism studies of valdecoxib by liquid chromatography/tandem mass spectrometry, we observed a novel mass…”
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A validated SPE–LC-MS/MS assay for Eplerenone and its hydrolyzed metabolite in human urine by Zhang, Ji Y, Fast, Douglas M, Breau, Alan P

“…An automated LC-MS/MS assay was validated to quantitate the first selective aldosterone blocker Eplerenone (I) and its hydrolyzed metabolite (II) in human…”
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Disposition and pharmacokinetics of L-N6-(1-iminoethyl)lysine-5-tetrazole-amide, a selective iNOS inhibitor, in rats by Zhang, Ji Y, Wang, Yuefen, Milton, Mark N, Kraus, Lori, Breau, Alan P, Paulson, Susan K

“…The metabolism, pharmacokinetics, tissue distribution, and excretion of L-N6-(1-iminoethyl)lysine-5-tetrazole-amide (L-NIL-TA), a selective inducible NO…”
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Study on improving interface bonding performance of magnesium potassium phosphate cement mortar by Zhang, J., Ji, Y.,  Xu, Z., Xue, Q., Zhou, Y., Jin, C.

“…To enhance the interfacial bonding performance between magnesium potassium phosphate cement (MKPC) repair mortar and matrix concrete, in this study, MKPC…”
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Regiospecific and enantioselective metabolism of 8,9-epoxyeicosatrienoic acid by cyclooxygenase by Zhang, J Y, Prakash, C, Yamashita, K, Blair, I A

“…8(S),9(R)-epoxyeicosatrienoic acid, a major product of the renal cortex, was found to be a substrate for cyclooxygenase from human platelets and ram seminal…”
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Enhanced Enrichment Characteristics and Inhibition Kinetics Characteristics of the Anammox Granular Sludge by Wang, Z.Z., Ji, Y., Zhang, H., Yan, L.N., Zhao, D., Gao, P.

“…The anammox granular sludge was enriched by shortening the hydraulic retention time (HRT) (from 27 h to 6.67 h) in the UASB reactor, which was fed with…”
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Direct resolution of epoxyeicosatrienoic acid enantiomers by chiral-phase high-performance liquid chromatography by Zhang, J Y, Blair, I A

“…A chromatographic method was developed to separate enantiomers of four regioisomeric epoxyeicosatrienoic acids (EETs), which are cytochrome P-450 monooxygenase…”
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Global reprogramming of transcription and metabolism in Medicago truncatula during progressive drought and after rewatering by ZHANG, JI‐YI, CRUZ DE CARVALHO, MARIA H., TORRES‐JEREZ, IVONE, KANG, YUN, ALLEN, STACY N., HUHMAN, DAVID V., TANG, YUHONG, MURRAY, JEREMY, SUMNER, LLOYD W., UDVARDI, MICHAEL K.

“…Medicago truncatula is a model legume forage crop native to the arid and semi‐arid environments of the Mediterranean. Given its drought‐adapted nature, it is…”
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20-Hydroxyeicosatetraenoic acid is excreted as a glucuronide conjugate in human urine by Prakash, C, Zhang, J Y, Falck, J R, Chauhan, K, Blair, I A

“…20-hydroxyeicosatetraenoic acid, a major renal P-450 metabolite of arachidonic acid, has been quantified in human urine using capillary gas…”
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Multi-objective optimization design method of the high-speed train head by Yu, Meng-ge, Zhang, Ji-ye, Zhang, Wei-hua

“…With the continuous improvement of the train speed, the dynamic environment of trains turns out to be aerodynamic domination. Solving the aerodynamic problems…”
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Molecular mechanisms underlying the cholesterollowering effect of Ginkgo biloba extract in hepatocytes： a comparative study with Iovastatin by Zuo-quan XIE Gai LIANG Lu ZHANG Qi WANG Yi QU Yang GAO Li-bo LIN Sai YE Ji ZHANG Hui WANG Guo-ping ZHAO Qing-hua ZHANG

“…Aim： To explore the molecular mechanisms underlying the cholesterol-lowering effect of a Ginkgo biloba extract （GBE）. Methods. Enzyme activity, cholesterol…”
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