Search Results - "ZHA, JUANMIN"

Inflammation-induced Occludin Downregulation Limits Epithelial Apoptosis by Suppressing Caspase-3 Expression by Kuo, Wei-Ting, Shen, Le, Zuo, Li, Shashikanth, Nitesh, Ong, Ma.Lora Drizella M., Wu, Licheng, Zha, Juanmin, Edelblum, Karen L., Wang, Yitang, Wang, Yingmin, Nilsen, Steven P., Turner, Jerrold R.

“…Epithelial tight junctions are compromised in gastrointestinal disease. Processes that contribute to the resulting barrier loss include endocytic occludin…”
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Intracellular MLCK1 diversion reverses barrier loss to restore mucosal homeostasis by Graham, W. Vallen, He, Weiqi, Marchiando, Amanda M., Zha, Juanmin, Singh, Gurminder, Li, Hua-Shan, Biswas, Amlan, Ong, Ma. Lora Drizella M., Jiang, Zhi-Hui, Choi, Wangsun, Zuccola, Harmon, Wang, Yitang, Griffith, James, Wu, Jingshing, Rosenberg, Harry J., Wang, Yingmin, Snapper, Scott B., Ostrov, David, Meredith, Stephen C., Miller, Lawrence W., Turner, Jerrold R.

“…Epithelial barrier loss is a driver of intestinal and systemic diseases. Myosin light chain kinase (MLCK) is a key effector of barrier dysfunction and a…”
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Glucocorticoids transcriptionally regulate miR-27b expression promoting body fat accumulation via suppressing the browning of white adipose tissue by Kong, Xiaocen, Yu, Jing, Bi, Jianhua, Qi, Hanmei, Di, Wenjuan, Wu, Lin, Wang, Long, Zha, Juanmin, Lv, Shan, Zhang, Feng, Li, Yan, Hu, Fang, Liu, Feng, Zhou, Hong, Liu, Juan, Ding, Guoxian

“…Long-term glucocorticoid (GC) treatment induces central fat accumulation and metabolic dysfunction. We demonstrate that microRNA-27b (miR-27b) plays a central…”
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Occludin OCEL-domain interactions are required for maintenance and regulation of the tight junction barrier to macromolecular flux by Buschmann, Mary M, Shen, Le, Rajapakse, Harsha, Raleigh, David R, Wang, Yitang, Wang, Yingmin, Lingaraju, Amulya, Zha, Juanmin, Abbott, Elliot, McAuley, Erin M, Breskin, Lydia A, Wu, Licheng, Anderson, Kenneth, Turner, Jerrold R, Weber, Christopher R

“…In vitro and in vivo studies implicate occludin in the regulation of paracellular macromolecular flux at steady state and in response to tumor necrosis factor…”
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TFAP2E methylation promotes 5‑fluorouracil resistance via exosomal miR‑106a‑5p and miR‑421 in gastric cancer MGC‑803 cells by Jingyue, Sun, Xiao, Wang, Juanmin, Zha, Wei, Li, Daoming, Li, Hong, Xu

“…Hypermethylation of transcription factor activating enhancer‑binding protein 2e (TFAP2E) has been reported to be associated with chemoresistance to…”
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Nuclear receptor modulators inhibit osteosarcoma cell proliferation and tumour growth by regulating the mTOR signaling pathway by Yuan, Baoshi, Shi, Kexin, Zha, Juanmin, Cai, Yujia, Gu, Yue, Huang, Kai, Yue, Wenchang, Zhai, Qiaocheng, Ding, Ning, Ren, Wenyan, He, Weiqi, Xu, Ying, Wang, Tao

“…Osteosarcoma is the most common primary malignant bone tumour in children and adolescents. Chemoresistance leads to poor responses to conventional therapy in…”
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BVT.2733, a selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor, attenuates obesity and inflammation in diet-induced obese mice by Wang, Long, Liu, Juan, Zhang, Aisen, Cheng, Peng, Zhang, Xiao, Lv, Shan, Wu, Lin, Yu, Jing, Di, Wenjuan, Zha, Juanmin, Kong, Xiaocen, Qi, Hanmei, Zhong, Yi, Ding, Guoxian

“…Inhibition of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is being pursued as a new therapeutic approach for the treatment of obesity and metabolic…”
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11β-hydroxysteroid dehydrogenase type 1 selective inhibitor BVT.2733 protects osteoblasts against endogenous glucocorticoid induced dysfunction by Wu, Lin, Qi, Hanmei, Zhong, Yi, Lv, Shan, Yu, Jing, Liu, Juan, Wang, Long, Bi, Jianhua, Kong, Xiaocen, Di, Wenjuan, Zha, Juanmin, Liu, Feng, Ding, Guoxian

“…Pharmacologic glucocorticoids (GCs) inhibit osteoblast function and induce osteoporosis. 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) may play a role in…”
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Adipose tissue-targeted 11β-hydroxysteroid dehydrogenase type 1 inhibitor protects against diet-induced obesity by Liu, Juan, Wang, Long, Zhang, Aisen, Di, Wenjuan, Zhang, Xiao, Wu, Lin, Yu, Jing, Zha, Juanmin, Lv, Shan, Cheng, Peng, Hu, Miao, Li, Yujie, Qi, Hanmei, Ding, Guoxian, Zhong, Yi

“…Current pharmacological treatments for obesity and metabolic syndrome have various limitations. Recently, adipose tissue 11β-hydroxysteroid dehydrogenase type…”
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One-Step Construction of Lentiviral Reporter Using Red-Mediated Recombination by Zha, Juanmin, Chen, Xin, Li, Chaojun, Zhu, Minsheng, Ding, Guoxian, He, Weiqi

“…Current approaches to generate lentiviral vectors, which have been used extensively for gene therapy, are time consuming and require a large expenditure. Here,…”
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11β-hydroxysteroid dehydrogenase type 1 selective inhibitor BVT.2733 protects osteoblasts against endogenous glucocorticoid induced dysfunction by Lin Wu, Hanmei Qi, Yi Zhong, Shan Lv, Jing Yu, Juan Liu, Long Wang, Jianhua Bi, Xiaocen Kong, Wenjuan Di, Juanmin Zha, Feng Liu, Guoxian Ding

“…[Abstract. ] Pharmacologic glucocorticoids (GCs) inhibit osteoblast function and induce osteoporosis. 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) may…”
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Correlation of obesity and osteoporosis: Effect of free fatty acids on bone marrow-derived mesenchymal stem cell differentiation by LV, SHAN, WU, LIN, CHENG, PENG, YU, JING, ZHANG, AISEN, ZHA, JUANMIN, LIU, JUAN, WANG, LONG, DI, WENJUAN, HU, MIAO, QI, HANMEI, LI, YUJIE, DING, GUOXIAN

“…Studies on the relationship between obesity and bone have recently become widespread. The aim of this study was to investigate the effect of obesity on bone,…”
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Adipose tissue-targeted 11.BETA.-hydroxysteroid dehydrogenase type 1 inhibitor protects against diet-induced obesity by Liu, Juan, Wang, Long, Zhang, Aisen, Di, Wenjuan, Zhang, Xiao, Wu, Lin, Yu, Jing, Zha, Juanmin, Lv, Shan, Cheng, Peng, Hu, Miao, Li, Yujie, Qi, Hanmei, Ding, Guoxian, Zhong, Yi

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Mesenchymal stromal cells confer breast cancer doxorubicin resistance by producing hyaluronan by Liu, Zhanhong, Hou, Pengbo, Fang, Jiankai, Zhu, Jingyu, Zha, Juanmin, Liu, Rui, Ding, Yayun, Zuo, Muqiu, Li, Peishan, Cao, Lijuan, Feng, Chao, Melino, Gerry, Shao, Changshun, Shi, Yufang

“…Chemotherapy resistance represents a major cause of therapeutic failure and mortality in cancer patients. Mesenchymal stromal cells (MSCs), an integral…”
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Mechanisms underlying distinct subcellular localization and regulation of epithelial long myosin light-chain kinase splice variants by Chanez-Paredes, Sandra D., Abtahi, Shabnam, Zha, Juanmin, Li, Enkai, Marsischky, Gerald, Zuo, Li, Grey, Michael J., He, Weiqi, Turner, Jerrold R.

“…Intestinal epithelia express two long myosin light-chain kinase (MLCK) splice variants, MLCK1 and MLCK2, which differ by the absence of a complete…”
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Tu1831 MYPT1 Is a Critical Regulator of Intestinal Epithelial Cell Survival by Zha, Juanmin, He, Weiqi, Odenwald, Matthew, Turner, Jerrold

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Identification and characterization of the domain that mediates actin binding and directs basal and TNF‐induced myosin light chain kinase 1 (MLCK1) recruitment to the perijunctional actomyosin ring by Chanez‐Paredes, Sandra D., He, Weiqi, Zha, Juanmin, Zuo, Li, Graham, W V., Rosenberg, Harry J., Turner, Jerrold R.

“…Two myosin light chain kinase (MLCK) splice variants are expressed within intestinal epithelial cells, MLCK1 and MLCK2. These differ by a single exon that…”
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Selective Inhibition of 11[beta]-Hydroxysteroid Dehydrogenase Type 1 Attenuates High-Fat Diet-Induced Hepatic Steatosis in Mice by Li, Huashan, Sheng, Jianying, Wang, Jing, Gao, Haiting, Yu, Jing, Ding, Guoxian, Ding, Ning, He, Weiqi, Zha, Juanmin

“…Introduction: The effect of 11[beta]-hydroxysteroid dehydrogenase type1 (11[beta]-HSD1) inhibition on hepatic steatosis is incompletely understood. Here, we…”
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Mechanisms underlying distinct subcellular localizations and regulation of epithelial long myosin light chain kinase (MLCK) splice variants by Chanez-Paredes, Sandra D, Abtahi, Shabnam, Zha, Juanmin, Li, Enkai, Marsischky, Gerald, Zuo, Li, Grey, Michael J, He, Weiqi, Turner, Jerrold R

“…Intestinal epithelia express two long myosin light chain kinase (MLCK) splice variants, MLCK1 and MLCK2 that differ by the absence of a complete…”
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TFAP2E methylation promotes 5‑fluorourail resistance via exosomal miR‑106a‑5p and miR‑421 in gastric cancer MGC‑803 cells by Jingyue, Sun, Xiao, Wang, Juanmin, Zha, Wei, Li, Daoming, Li, Hong, Xu

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