Search Results - "ZESCHNIGK, Michael"

Acquired IFNγ resistance impairs anti-tumor immunity and gives rise to T-cell-resistant melanoma lesions by Sucker, Antje, Zhao, Fang, Pieper, Natalia, Heeke, Christina, Maltaner, Raffaela, Stadtler, Nadine, Real, Birgit, Bielefeld, Nicola, Howe, Sebastian, Weide, Benjamin, Gutzmer, Ralf, Utikal, Jochen, Loquai, Carmen, Gogas, Helen, Klein-Hitpass, Ludger, Zeschnigk, Michael, Westendorf, Astrid M., Trilling, Mirko, Horn, Susanne, Schilling, Bastian, Schadendorf, Dirk, Griewank, Klaus G., Paschen, Annette

“…Melanoma treatment has been revolutionized by antibody-based immunotherapies. IFNγ secretion by CD8 + T cells is critical for therapy efficacy having…”
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No evidence for intervention-associated DNA methylation changes in monocytes of patients with posttraumatic stress disorder by Hummel, Elisabeth, Elgizouli, Magdeldin, Sicorello, Maurizio, Leitão, Elsa, Beygo, Jasmin, Schröder, Christopher, Zeschnigk, Michael, Müller, Svenja, Herpertz, Stephan, Moser, Dirk, Kessler, Henrik, Horsthemke, Bernhard, Kumsta, Robert

“…DNA methylation patterns can be responsive to environmental influences. This observation has sparked interest in the potential for psychological interventions…”
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eIF1A residues implicated in cancer stabilize translation preinitiation complexes and favor suboptimal initiation sites in yeast by Martin-Marcos, Pilar, Zhou, Fujun, Karunasiri, Charm, Zhang, Fan, Dong, Jinsheng, Nanda, Jagpreet, Kulkarni, Shardul D, Sen, Neelam Dabas, Tamame, Mercedes, Zeschnigk, Michael, Lorsch, Jon R, Hinnebusch, Alan G

“…The translation pre-initiation complex (PIC) scans the mRNA for an AUG codon in favorable context, and AUG recognition stabilizes a closed PIC conformation…”
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Early detection of metastatic uveal melanoma by the analysis of tumor‐specific mutations in cell‐free plasma DNA by Le Guin, Claudia H. D., Bornfeld, Norbert, Bechrakis, Nikolaos E., Jabbarli, Leyla, Richly, Heike, Lohmann, Dietmar R., Zeschnigk, Michael

“…Background Eye salvaging therapy of malignant melanomas of the uvea can preserve the eye in most cases, but still about half of patients die from metastatic…”
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Quantification of regulatory T cells in septic patients by real-time PCR-based methylation assay and flow cytometry by Tatura, Roman, Zeschnigk, Michael, Adamzik, Michael, Probst-Kepper, Michael, Buer, Jan, Kehrmann, Jan

“…During sepsis, a relative increase of regulatory T (Treg) cells has been reported. Its persistence is associated with lymphocyte anergy, immunoparalysis and a…”
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Reduced Staphylococcus Abundance Characterizes the Lesional Microbiome of Actinic Keratosis Patients after Field-Directed Therapies by Kehrmann, Jan, Koch, Fiona, Zumdick, Skrollan, Höwner, Anna, Best, Lara, Masshöfer, Lars, Scharfenberg, Sarah, Zeschnigk, Michael, Becker, Jürgen C, Schadendorf, Dirk, Buer, Jan, Roesch, Alexander

“…Skin microbiome dysbiosis with a Staphylococcus overabundance is a feature of actinic keratosis (AK) and squamous skin carcinoma (SCC) patients. The impact of…”
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Pancreatic cancer acquires resistance to MAPK pathway inhibition by clonal expansion and adaptive DNA hypermethylation by Godfrey, Laura K, Forster, Jan, Liffers, Sven-Thorsten, Schröder, Christopher, Köster, Johannes, Henschel, Leonie, Ludwig, Kerstin U, Lähnemann, David, Trajkovic-Arsic, Marija, Behrens, Diana, Scarpa, Aldo, Lawlor, Rita T, Witzke, Kathrin E, Sitek, Barbara, Johnsen, Steven A, Rahmann, Sven, Horsthemke, Bernhard, Zeschnigk, Michael, Siveke, Jens T

“…Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with poor prognosis. It is marked by extraordinary resistance to conventional therapies…”
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EFS shows biallelic methylation in uveal melanoma with poor prognosis as well as tissue-specific methylation by Neumann, Lisa C, Weinhäusel, Andreas, Thomas, Stefanie, Horsthemke, Bernhard, Lohmann, Dietmar R, Zeschnigk, Michael

“…Uveal melanoma (UM) is a rare eye tumor. There are two classes of UM, which can be discriminated by the chromosome 3 status or global mRNA expression profile…”
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Ultradeep sequencing detects GNAQ and GNA11 mutations in cell‐free DNA from plasma of patients with uveal melanoma by Metz, Claudia H. D., Scheulen, Max, Bornfeld, Norbert, Lohmann, Dietmar, Zeschnigk, Michael

“…Elevated levels of cell‐free DNA (cfDNA) are frequently observed in tumor patients. Activating mutations in exon 4 (R183) and exon 5 (Q209) of GNAQ and GNA11…”
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A Single-Tube PCR Test for the Diagnosis of Angelman and Prader-Willi Syndrome Based on Allelic Methylation Differences at the SNRPN Locus by Zeschnigk, Michael, Lich, Christina, Buiting, Karin, Doerfler, Walter, Horsthemke, Bernhard

“…The analysis of allelic methylation differences in 15ql 1-ql 3 has been established as a valid test for the Angelman and Prader-Willi syndromes. Current tests…”
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Involvement of M-cadherin in terminal differentiation of skeletal muscle cells by Zeschnigk, M, Kozian, D, Kuch, C, Schmoll, M, Starzinski-Powitz, A

“…Cadherins are a gene family encoding calcium-dependent cell adhesion proteins which are thought to act in the establishment and maintenance of tissue…”
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IGF2 H19 hypomethylation in Silver-Russell syndrome and isolated hemihypoplasia by ZESCHNIGK, Michael, ALBRECHT, Beate, BUITING, Karin, KANBER, Deniz, EGGERMANN, Thomas, BINDER, Gerhard, GROMOLL, Jörg, PROTT, Eva-Christina, SELAND, Saskia, HORSTHEMKE, Bernhard

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Relationships between DNA methylation and expression in erythrocyte membrane protein (band 3, protein 4.2, and β-spectrin) genes during human erythroid development and differentiation by REMUS, Ralph, KANZAKI, Akio, DOERFLER, Walter, YAWATA, Yoshihito, YAWATA, Ayumi, WADA, Hideho, NAKANISHI, Hidekazu, SUGIHARA, Takashi, ZESCHNIGK, Michael, ZUTHER, Ines, SCHMITZ, Birgit, NAUMANN, Frauke

“…Red cell membrane proteins are sequentially expressed during erythroid development and differentiation. Spectrins have already been synthesized in early…”
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Exome sequencing identifies recurrent somatic mutations in EIF1AX and SF3B1 in uveal melanoma with disomy 3 by Martin, Marcel, Maßhöfer, Lars, Temming, Petra, Rahmann, Sven, Metz, Claudia, Bornfeld, Norbert, van de Nes, Johannes, Klein-Hitpass, Ludger, Hinnebusch, Alan G, Horsthemke, Bernhard, Lohmann, Dietmar R, Zeschnigk, Michael

“…Michael Zeschnigk and colleagues identify recurrent somatic mutations of EIF1AX and SF3B1 in uveal melanomas with disomy 3. The EIF1AX mutations specifically…”
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DNA methylation in promoter regions of red cell membrane protein genes in healthy individuals and patients with hereditary membrane disorders by REMUS, Ralph, KANZAKI, Akio, DOERFLER, Walter, YAWATA, Yoshihito, YAWATA, Ayumi, NAKANISHI, Hidekazu, WADA, Hideho, SUGIHARA, Takashi, ZESCHNIGK, Michael, ZUTHER, Ines, SCHMITZ, Birgit, NAUMANN, Frauke

“…The methylation state of 5'-CG-3' sites is known to be linked to the regulation of promoter function by modulating DNA-protein interactions and to the…”
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Mass Spectrometry-Based Profiling of Histone Post-Translational Modifications in Uveal Melanoma Tissues, Human Melanocytes, and Uveal Melanoma Cell Lines - A Pilot Study by Herwig-Carl, Martina C, Sharma, Amit, Tischler, Verena, Pelusi, Natalie, Loeffler, Karin U, Holz, Frank G, Zeschnigk, Michael, Landreville, Solange, Auw-Haedrich, Claudia, Noberini, Roberta, Bonaldi, Tiziana

“…Epigenetic alterations in uveal melanoma (UM) are still neither well characterized, nor understood. In this pilot study, we sought to provide a deeper insight…”
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Release of Cell-Free Tumor DNA in the Plasma of Uveal Melanoma Patients Under Radiotherapy by Kim, Viktoria, Guberina, Maja, Bechrakis, Nikolaos E., Lohmann, Dietmar R., Zeschnigk, Michael, Le Guin, Claudia H. D.

“…PurposeUveal melanoma (UM) is a tumor of the eye that metastasizes in approximately half of cases. Prognostic testing requires accessibility to tumor tissue,…”
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Locus-Specific DNA Methylation Analysis by Targeted Deep Bisulfite Sequencing by Leitão, Elsa, Beygo, Jasmin, Zeschnigk, Michael, Klein-Hitpass, Ludger, Bargull, Marcel, Rahmann, Sven, Horsthemke, Bernhard

“…DNA methylation, i.e., the methylation of cytosine at carbon atom C5, has an important role in the regulation of gene expression. The methylation status of…”
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Comparing the Prognostic Value of BAP1 Mutation Pattern, Chromosome 3 Status, and BAP1 Immunohistochemistry in Uveal Melanoma by van de Nes, Johannes A.P, Nelles, Jasmin, Kreis, Stefan, Metz, Claudia H.D, Hager, Thomas, Lohmann, Dietmar R, Zeschnigk, Michael

“…Uveal melanoma (UM), a tumor of the eye, can be divided into 2 major classes correlating with patients’ prognosis. Gene expression profiles and chromosome 3…”
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CRISPR/Cas9-mediated demethylation of FOXP3-TSDR toward Treg-characteristic programming of Jurkat T cells by Wilk, Camilla, Effenberg, Laura, Abberger, Hanna, Steenpass, Laura, Hansen, Wiebke, Zeschnigk, Michael, Kirschning, Carsten, Buer, Jan, Kehrmann, Jan

“…•CRISPR-dCas9-TET constructs actively demethylate FOXP3-TSDR in Jurkat T cells.•A subset of three sgRNA constructs is sufficient to actively demethylate…”
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