Search Results - "ZENK, Sebastian"
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Stabilization of Hypoxia-Inducible Factor Promotes Antimicrobial Activity of Human Macrophages Against Mycobacterium tuberculosis
Published in Frontiers in immunology (02-06-2021)“…Hypoxia-inducible factor (HIF) is a key oxygen sensor that controls gene expression patterns to adapt cellular metabolism to hypoxia. Pharmacological…”
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Lipoarabinomannan-Responsive Polycytotoxic T Cells Are Associated with Protection in Human Tuberculosis
Published in American journal of respiratory and critical care medicine (01-08-2016)“…The development of host-targeted, prophylactic, and therapeutic interventions against tuberculosis requires a better understanding of the immune mechanisms…”
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Functional Analysis of the Salmonella Pathogenicity Island 2-Mediated Inhibition of Antigen Presentation in Dendritic Cells
Published in Infection and Immunity (01-11-2008)“…Salmonella enterica is a facultative intracellular pathogen that is able to modify host cell functions by means of effector proteins translocated by the type…”
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Liposomal delivery of lipoarabinomannan triggers Mycobacterium tuberculosis specific T-cells
Published in Tuberculosis (Edinburgh, Scotland) (01-07-2015)“…Summary Lipoarabinomannan (LAM) is a major cell wall component of Mycobacterium tuberculosis ( Mtb ). LAM specific human T-lymphocytes release interferon-γ…”
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type III secretion system needle tip complex mediates host cell sensing and translocon insertion
Published in Molecular microbiology (01-03-2007)“…Type III secretion systems (T3SSs) are essential virulence determinants of many Gram-negative bacterial pathogens. The Shigella T3SS consists of a cytoplasmic…”
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O-antigen delays lipopolysaccharide recognition and impairs antibacterial host defense in murine intestinal epithelial cells
Published in PLoS pathogens (01-09-2009)“…Although Toll-like receptor (TLR) 4 signals from the cell surface of myeloid cells, it is restricted to an intracellular compartment and requires ligand…”
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Role of Salmonella enterica Lipopolysaccharide in Activation of Dendritic Cell Functions and Bacterial Containment
Published in The Journal of immunology (1950) (15-08-2009)“…In contrast to nonpathogenic bacteria, the Gram-negative pathogen Salmonella enterica is not eradicated, but persists in murine dendritic cells (DC). The…”
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The Needle Component of the Type III Secreton of Shigella Regulates the Activity of the Secretion Apparatus
Published in The Journal of biological chemistry (30-12-2005)“…Gram-negative bacteria commonly interact with eukaryotic host cells by using type III secretion systems (TTSSs or secretons). TTSSs serve to transfer bacterial…”
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Hypoxia promotes Mycobacterium tuberculosis-specific up-regulation of granulysin in human T cells
Published in Medical microbiology and immunology (01-06-2016)“…Oxygen tension affects local immune responses in inflammation and infection. In tuberculosis mycobacteria avoid hypoxic areas and preferentially persist and…”
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Diagnosis of neuroschistosomiasis by antibody specificity index and semi-quantitative real-time PCR from cerebrospinal fluid and serum
Published in Journal of medical microbiology (01-02-2014)“…We describe the case of a 16-year-old German male expatriate from Ghana who presented with obstipation, dysuria, dysaesthesia of the gluteal region and the…”
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Identification of minor inner-membrane components of the Shigella type III secretion system 'needle complex'
Published in Microbiology (Society for General Microbiology) (01-08-2007)“…1 Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK 2 Laboratory of Molecular Biophysics, Department of…”
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O-antigen delays lipopolysaccharide recognition and impairs antibacterial host defense in murine intestinal epithelial cells
Published in PLoS pathogens (01-09-2009)“…Although Toll-like receptor (TLR) 4 signals from the cell surface of myeloid cells, it is restricted to an intracellular compartment and requires ligand…”
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O-Antigen Delays Lipopolysaccharide Recognition and Impairs Antibacterial Host Defense in Murine Intestinal Epithelial Cells: e1000567
Published in PLoS pathogens (01-09-2009)“…Although Toll-like receptor (TLR) 4 signals from the cell surface of myeloid cells, it is restricted to an intracellular compartment and requires ligand…”
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