Search Results - "ZEH, H. J"

The Beclin 1 network regulates autophagy and apoptosis by Kang, R, Zeh, H J, Lotze, M T, Tang, D

“…Beclin 1, the mammalian orthologue of yeast Atg6, has a central role in autophagy, a process of programmed cell survival, which is increased during periods of…”
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The HMGB1/RAGE inflammatory pathway promotes pancreatic tumor growth by regulating mitochondrial bioenergetics by Kang, R, Tang, D, Schapiro, N E, Loux, T, Livesey, K M, Billiar, T R, Wang, H, Van Houten, B, Lotze, M T, Zeh, H J

“…Tumor cells require increased adenosine triphosphate (ATP) to support anabolism and proliferation. The precise mechanisms regulating this process in tumor…”
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Strange attractors: DAMPs and autophagy link tumor cell death and immunity by Hou, W, Zhang, Q, Yan, Z, Chen, R, Zeh III, H J, Kang, R, Lotze, M T, Tang, D

“…Resistance to ‘apoptotic’ cell death is one of the major hallmarks of cancer, contributing to tumor development and therapeutic resistance. Damage-associated…”
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HMGB1 release and redox regulates autophagy and apoptosis in cancer cells by Tang, D, Kang, R, Cheh, C-W, Livesey, K M, Liang, X, Schapiro, N E, Benschop, R, Sparvero, L J, Amoscato, A A, Tracey, K J, Zeh, H J, Lotze, M T

“…The functional relationship and cross-regulation between autophagy and apoptosis is complex. In this study we show that the high-mobility group box 1 protein…”
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The receptor for advanced glycation end products (RAGE) sustains autophagy and limits apoptosis, promoting pancreatic tumor cell survival by Kang, R, Tang, D, Schapiro, N E, Livesey, K M, Farkas, A, Loughran, P, Bierhaus, A, Lotze, M T, Zeh, H J

“…Activation of the induced receptor for advanced glycation end products (RAGE) leads to initiation of NF- κ B and MAP kinase signaling pathways, resulting in…”
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The receptor for advanced glycation end products (RAGE) enhances autophagy and neutrophil extracellular traps in pancreatic cancer by Boone, B A, Orlichenko, L, Schapiro, N E, Loughran, P, Gianfrate, G C, Ellis, J T, Singhi, A D, Kang, R, Tang, D, Lotze, M T, Zeh, H J

“…Neutrophil extracellular traps (NETs) are formed when neutrophils expel their DNA, histones and intracellular proteins into the extracellular space or…”
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RAGE is essential for oncogenic KRAS-mediated hypoxic signaling in pancreatic cancer by Kang, R, Hou, W, Zhang, Q, Chen, R, Lee, Y J, Bartlett, D L, Lotze, M T, Tang, D, Zeh, H J

“…A hypoxic tumor microenvironment is characteristic of many cancer types, including one of the most lethal, pancreatic cancer. We recently demonstrated that the…”
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Apoptosis promotes early tumorigenesis by Tang, D, Lotze, M T, Kang, R, Zeh, H J

“…One hallmark of cancer is intrinsic or acquired resistance to apoptosis. Surprisingly, recent studies demonstrate that CD95/Fas/Apo1 and p53 upregulated…”
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High Avidity CTLs for Two Self-Antigens Demonstrate Superior In Vitro and In Vivo Antitumor Efficacy by Zeh, Herbert J., III, Perry-Lalley, Donna, Dudley, Mark E, Rosenberg, Steven A, Yang, James C

“…A majority of the human tumor-associated Ags characterized to date are derived from nonmutated "self"-proteins. Little is currently understood about the nature…”
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Oncolytic virotherapy for ovarian carcinomatosis using a replication-selective vaccinia virus armed with a yeast cytosine deaminase gene by Chalikonda, S, Kivlen, M H, O'Malley, M E, (Eric) Dong, X D, McCart, J A, Gorry, M C, Yin, X-Y, Brown, C K, Zeh, H J, Guo, Z S, Bartlett, D L

“…In this study, we assessed the ability of a highly tumor-selective oncolytic vaccinia virus armed with a yeast cytosine deaminase gene to infect and lyse human…”
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A Phase I Trial of Isolated Hepatic Perfusion (IHP) Using 5-FU and Oxaliplatin in Patients with Unresectable Isolated Liver Metastases from Colorectal Cancer by Magge, D., Zureikat, A. H., Bartlett, D. L., Holtzman, M. P., Choudry, H. A., Beumer, J. H., Pingpank, J. F., Holleran, J. L., Strychor, S., Cunningham, D. E., Jones, H. L., Zeh, H. J.

“…Background Isolated hepatic perfusion (IHP) with melphalan is an established approach for patients with unresectable metastatic liver lesions. This study…”
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Robotic-Assisted Major Pancreatic Resection by Zeh, H.J., MD, Bartlett, David L., MD, Moser, A. James, MD

“…Robotic-assisted major pancreatic resections allow recreation of time-tested open surgical procedures on a minimally invasive platform. Early outcomes from…”
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Effective eradication of established murine tumors with IL-12 gene therapy using a polycistronic retroviral vector by Tahara, H, Zitvogel, L, Storkus, WJ, Zeh, HJ, 3rd, McKinney, TG, Schreiber, RD, Gubler, U, Robbins, PD, Lotze, MT

“…Our recent studies using IL-12 protein or fibroblasts genetically engineered to secrete IL-12 have demonstrated profound antitumor effects of IL-12 in murine…”
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A new recombinant vaccinia with targeted deletion of three viral genes: its safety and efficacy as an oncolytic virus by YANG, S, GUO, Z. S, O'MALLEY, M. E, YIN, X, ZEH, H. J, BARTLETT, D. L

“…To enhance further the safety and efficacy of oncolytic vaccinia virus, we have developed a new virus with targeted deletions of three viral genes encoding…”
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Fibroblasts genetically engineered to secrete interleukin 12 can suppress tumor growth and induce antitumor immunity to a murine melanoma in vivo by TAHARA, H, ZEH, J. H, STORKUS, W. J, PAPPO, I, WATKINS, S. C, GUBLER, WOLF, S. F, ROBBINS, P. D, LOTZE, M. T

“…Interleukin 12 (IL-12), a disulfide-linked heterodimeric cytokine produced primarily by macrophages, is composed of light (p35) and heavy (p40) chains. It…”
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Algorithm-based care versus usual care for the early recognition and management of complications after pancreatic resection in the Netherlands: an open-label, nationwide, stepped-wedge cluster-randomised trial by Smits, F Jasmijn, Henry, Anne Claire, Besselink, Marc G, Busch, Olivier R, van Eijck, Casper H, Arntz, Mark, Bollen, Thomas L, van Delden, Otto M, van den Heuvel, Daniel, van der Leij, Christiaan, van Lienden, Krijn P, Moelker, Adriaan, Bonsing, Bert A, Borel Rinkes, Inne H, Bosscha, Koop, van Dam, Ronald M, Derksen, Wouter J M, den Dulk, Marcel, Festen, Sebastiaan, Groot Koerkamp, Bas, de Haas, Robbert J, Hagendoorn, Jeroen, van der Harst, Erwin, de Hingh, Ignace H, Kazemier, Geert, van der Kolk, Marion, Liem, Mike, Lips, Daan J, Luyer, Misha D, de Meijer, Vincent E, Mieog, J Sven, Nieuwenhuijs, Vincent B, Patijn, Gijs A, te Riele, Wouter W, Roos, Daphne, Schreinemakers, Jennifer M, Stommel, Martijn W J, Wit, Fennie, Zonderhuis, Babs A, Daamen, Lois A, van Werkhoven, C Henri, Molenaar, I Quintus, van Santvoort, Hjalmar C, Blomjous, JG, de Boer, MT, van den Boezem, P, Bouwense, S, Bruijnen, R, Buis, CI, del Chiaro, M, Coene, PP, Coolsen, M, Daams, F, Dejong, K, Draaisma, W, Eker, HH, Elsen, AH, Gerhards, MF, Hartog, H, Hoogwater, FJ, Imani, F, Jenniskens, S, de Jong, KP, Karsten, TM, Klaase, JM, de Kleine, RHJ, van Laarhoven, CJ, van der Lelij, H, Manusama, ER, Meerdink, M, Meijerink, M, Nederend, J, Nijkamp, MW, Nota, CL, Porte, RJ, Reef, J, de Reuver, P, van Rijswijk, C, Romkens, T, Rupert, C, van der Schelling, GP, Serafino, JP, Vos, LD, Vriens, MR, Beers-Vural, E, Wagtenberg, JM, Wijsman, JH, de Wilde, RF, Wolfgang, CL, Zeh, HJ

“…Early recognition and management of postoperative complications, before they become clinically relevant, can improve postoperative outcomes for patients,…”
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Identification of human melanoma peptides recognized by class I restricted tumor infiltrating T lymphocytes by Storkus, WJ, Zeh, HJ, 3d, Maeurer, MJ, Salter, RD, Lotze, MT

“…Using a newly described pH 3.3 acid elution technique, peptides were extracted by denaturation of class I molecules on the surface of human melanomas. HPLC…”
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Risk factors and outcomes of conversion in minimally invasive distal pancreatectomy: a systematic review by Balduzzi, A., van der Heijde, N., Alseidi, A., Dokmak, S., Kendrick, M. L., Polanco, P. M., Sandford, D. E., Shrikhande, S. V., Vollmer, C. M., Wang, S. E., Zeh, H. J., Hilal, M. Abu, Asbun, H. J., Besselink, M. G.

“…Purpose The reported conversion rates for minimally invasive distal pancreatectomy (MIDP) range widely from 2 to 38%. The identification of risk factors for…”
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Identification of T-cell epitopes: rapid isolation of class I-presented peptides from viable cells by mild acid elution by Storkus, W J, Zeh, 3rd, H J, Salter, R D, Lotze, M T

“…A novel method was developed to isolate immunogenic peptides (CD8+ T-cell epitopes) from class I complexes expressed at the cell surface of viable cells. Cells…”
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Vaccines for colorectal cancer by Zeh, Herbert J, Stavely-O'Carroll, Kevin, Choti, Michael A

“…Despite recent advances in the treatment of colorectal cancer, the overall survival rate for those patients with advanced locoregional disease remains less…”
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