Search Results - "ZDANOVSKY, A. G"

Simple and Efficient Method for Heterologous Expression of Clostridial Proteins by ZDANOVSKY, A. G, ZDANOVSKAIA, M. V

“…Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Mechanism of action of Pseudomonas exotoxin. Identification of a rate-limiting step by ZDANOVSKY, A. G, CHIRON, M, PASTAN, I, FITZGERALD, D. J

“…Pseudomonas exotoxin (PE) enters cells by receptor-mediated endocytosis and is cleaved by a cellular protease between Arg279 and Gly280 to produce an…”
Get full text

Construction and expression of diphtheria toxin-encoding gene derivatives in Escherichia coli by Zdanovsky, A G, Kulaeva, O I, Yankovsky, N K

“…We reported earlier that in the periplasmic space of Escherichia coli, truncated derivatives of diphtheria toxin undergo limited proteolysis [Zdanovsky et al.,…”
Get more information

Construction and expression in Escherichia coli of hybrid genes composed of sequences encoding diphtheria toxin and human CD4 receptor by Zdanovsky, A G, Zdanovskaia, M V, Sidorov, A V, Malyushova, V V, Zverev, V V, Andzhaparidze, O G, Debabov, V G

“…Derivatives of natural toxins possessing substituted receptor-recognition domains of different specificities can be used as instruments for the selective…”
Get more information

Bacterial toxins and their application by Zdanovsky, A G, Zdanovskaya, M V, Yankovsky, N K

“…The review deals with the structure of protein bacterial toxins, steps of the toxin molecule interaction with the target cell, molecular mechanisms of the…”
Get full text

Diphtheria toxin NAD affinity and ADP ribosyltransferase activity are reduced at tryptophan 153 substitutions for alanine or phenylalanine by Zdanovskaia, Marina V, Zdanovsky, Alexey G, Yankovsky, Nick K

“…Previous studies on chemical modifications of diphtheria toxin (DT) fragment A have suggested that the Trp153 amino acid residue is essential for the ADP…”
Get full text

Recombinant derivatives of clostridial neurotoxins as delivery vehicles for proteins and small organic molecules by Zdanovskaia, M V, Los, G, Zdanovsky, A G

“…Clostridial neurotoxins are the most powerful toxins known. Nevertheless, derivatives of these toxins may find broad applications both in science and medicine…”
Get full text

Peptide phage display library as source for inhibitors of clostridial neurotoxins by Zdanovsky, A G, Karassina, N V, Simpson, D, Zdanovskaia, M V

“…Clostridial neurotoxins are the most powerful toxins known. There are no available antidotes to neutralize neurotoxins after they have been internalized by…”
Get full text

Recombinant Listeria strains producing the nontoxic L-chain of botulinum neurotoxin A in a soluble form by Vertiev, Yuri V, Zdanovsky, Alex G, Shevelev, Alexei B, Borinskaya, Svetlana A, Gening, Egor L, Martin, Thomas, Ivanov, Pavel A, Yankovsky, Nick K

“…Fragments of Clostridium botulinum neurotoxin A (BoNT/A) gene ( botA) were expressed in Listeria monocytogenes ATCC10527 to produce the L-chain of the toxin in…”
Get full text

Generation of a Potent Chimeric Toxin by Replacement of Domain III of Pseudomonas Exotoxin with Ricin A Chain-KDEL by Pitcher, Carol, Roberts, Lynne, Fawell, Stephen, Zdanovsky, Alex G, FitzGerald, David J, Lord, J. Michael

“…Following cellular uptake, Pseudomonas exotoxin (PE) is cleaved by cellular protease which generates an enzymatically active C-terminal fragment (amino acids…”
Get full text

Ligand-toxin hybrids directed to the alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein exhibit lower toxicity than native Pseudomonas exotoxin by Zdanovsky, A G, Zdanovskaia, M V, Strickland, D, FitzGerald, D J

“…Pseudomonas exotoxin (PE) binds the heavy chain of the alpha2-macroglobulin receptor/low density lipoprotein receptor-related protein (LRP). To understand the…”
Get full text

Ligand-toxin hybrids directed to the alpha sub(2)-macroglobulin receptor/low density lipoprotein receptor-related protein exhibit lower toxicity than native Pseudomonas exotoxin by Zdanovsky, A G, Zdanovskaia, M V, Strickland, D, FitzGerald, D J

“…Pseudomonas exotoxin (PE) binds the heavy chain of the alpha sub(2)-macroglobulin receptor/low density lipoprotein receptor-related protein (LRP). To…”
Get full text