Search Results - "ZARDO, GIUSEPPE"

MicroRNA in Control of Gene Expression: An Overview of Nuclear Functions by Catalanotto, Caterina, Cogoni, Carlo, Zardo, Giuseppe

“…The finding that small non-coding RNAs (ncRNAs) are able to control gene expression in a sequence specific manner has had a massive impact on biology. Recent…”
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The Role of H3K4 Trimethylation in CpG Islands Hypermethylation in Cancer by Zardo, Giuseppe

“…CpG methylation in transposons, exons, introns and intergenic regions is important for long-term silencing, silencing of parasitic sequences and alternative…”
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Polycombs and microRNA-223 regulate human granulopoiesis by transcriptional control of target gene expression by Zardo, Giuseppe, Ciolfi, Alberto, Vian, Laura, Starnes, Linda M., Billi, Monia, Racanicchi, Serena, Maresca, Carmen, Fazi, Francesco, Travaglini, Lorena, Noguera, Nelida, Mancini, Marco, Nanni, Mauro, Cimino, Giuseppe, Lo-Coco, Francesco, Grignani, Francesco, Nervi, Clara

“…Epigenetic modifications regulate developmental genes involved in stem cell identity and lineage choice. NFI-A is a posttranscriptional microRNA-223 (miR-223)…”
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Epigenetic Silencing of the Myelopoiesis Regulator microRNA-223 by the AML1/ETO Oncoprotein by Fazi, Francesco, Racanicchi, Serena, Zardo, Giuseppe, Starnes, Linda M., Mancini, Marco, Travaglini, Lorena, Diverio, Daniela, Ammatuna, Emanuele, Cimino, Giuseppe, Lo-Coco, Francesco, Grignani, Francesco, Nervi, Clara

“…Hematopoietic transcription factors are involved in chromosomal translocations, which generate fusion proteins contributing to leukemia pathogenesis. Analysis…”
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Myc-binding-site recognition in the human genome is determined by chromatin context by Amati, Bruno, Guccione, Ernesto, Martinato, Francesca, Finocchiaro, Giacomo, Luzi, Lucilla, Tizzoni, Laura, Dall' Olio, Valentina, Zardo, Giuseppe, Nervi, Clara, Bernard, Loris

“…Large-scale chromatin immunoprecipitation (ChIP) studies have been effective in unravelling the distribution of DNA-binding transcription factors along…”
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PAR level mediates the link between ROS and inflammatory response in patients with type 2 diabetes mellitus by Zampieri, Michele, Karpach, Katsiaryna, Salerno, Gerardo, Raguzzini, Anna, Barchetta, Ilaria, Cimini, Flavia Agata, Dule, Sara, De Matteis, Giovanna, Zardo, Giuseppe, Borro, Marina, Peluso, Ilaria, Cavallo, Maria Gisella, Reale, Anna

“…Type 2 diabetes mellitus (T2DM) is characterized by disrupted glucose homeostasis and metabolic abnormalities, with oxidative stress and inflammation playing…”
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Reversing HOXA9 oncogene activation by PI3K inhibition: epigenetic mechanism and prognostic significance in human glioblastoma by Costa, Bruno Marques, Smith, Justin S., Chen, Ying, Chen, Justin, Phillips, Heidi S., Aldape, Kenneth D., Zardo, Giuseppe, Nigro, Janice, James, C. David, Fridlyand, Jane, Reis, R. M., Costello, Joseph F.

“…HOXA genes encode critical transcriptional regulators of embryonic development that have been implicated in cancer. In this study, we documented functional…”
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Transcriptional targeting by microRNA-Polycomb complexes: A novel route in cell fate determination by Zardo, Giuseppe, Ciolfi, Alberto, Vian, Laura, Billi, Monia, Racanicchi, Serena, Grignani, Francesco, Nervi, Clara

“…Advances in the understanding of the epigenetic events underlying the regulation of developmental genes expression and cell lineage commitment are revealing…”
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Heterochromatic gene repression of the retinoic acid pathway in acute myeloid leukemia by Fazi, Francesco, Zardo, Giuseppe, Gelmetti, Vania, Travaglini, Lorena, Ciolfi, Alberto, Di Croce, Luciano, Rosa, Alessandro, Bozzoni, Irene, Grignani, Francesco, Lo-Coco, Francesco, Pelicci, Pier Giuseppe, Nervi, Clara

“…Alteration of lineage-specific transcriptional programs for hematopoiesis causes differentiation block and promotes leukemia development. Here, we show that…”
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Gene expression profiling identifies a subset of adult T-cell acute lymphoblastic leukemia with myeloid-like gene features and over-expression of miR-223 by CHIARETTI, Sabina, MESSINA, Monica, BOZZONI, Irene, FOZZA, Claudio, CANDONI, Anna, GUARINI, Anna, FOA, Robin, TAVOLARO, Simona, ZARDO, Giuseppe, ELIA, Loredana, VITALE, Antonella, FATICA, Alessandro, GOREL, Paolo, PICIOCCHI, Alfonso, SCAPPUCCI, Gina

“…Until recently, few molecular aberrations were recognized in acute lymphoblastic leukemia of T-cell origin; novel lesions have recently been identified and a…”
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Epigenetic treatment of myelodysplastic syndromes and acute myeloid leukemias by Leone, Giuseppe, D'Alò, Francesco, Zardo, Giuseppe, Voso, Maria Teresa, Nervi, Clara

“…Epigenetic mechanisms affecting chromatin structure contribute to regulate gene expression and assure the inheritance of information, which are essential for…”
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Dynamic and reversibility of heterochromatic gene silencing in human disease by Zardo, Giuseppe, Fazi, Francesco, Travaglini, Lorena, Nervi, Clara

“…In eukaryotic organisms cellular fate and tissue specific gene expression are regulated by the activity of proteins known as transcription factors that by…”
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The Unmethylated State of CpG Islands in Mouse Fibroblasts Depends on the Poly(ADP-ribosyl)ation Process by Zardo, G, Caiafa, P

“…In vivo and in vitro experiments carried out on L929 mouse fibroblasts suggested that the poly(ADP-ribosyl) ation process acts somehow as a protecting agent…”
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Counteracting aged DNA methylation states to combat ageing and age-related diseases by Reale, Anna, Tagliatesta, Stefano, Zardo, Giuseppe, Zampieri, Michele

“…DNA methylation (DNAm) overwrites information about multiple extrinsic factors on the genome. Age is one of these factors. Age causes characteristic DNAm…”
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Modifications of H3K4 methylation levels are associated with DNA hypermethylation in acute myeloid leukemia by Scalea, Stefania, Maresca, Carmen, Catalanotto, Caterina, Marino, Rachele, Cogoni, Carlo, Reale, Anna, Zampieri, Michele, Zardo, Giuseppe

“…The ‘instructive model’ of aberrant DNA methylation in human tumors is based on the observation that CpG islands prone to hypermethylation in cancers are…”
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YY1 Knockdown Relieves the Differentiation Block and Restores Apoptosis in AML Cells by Noguera, Nelida Ines, Travaglini, Serena, Scalea, Stefania, Catalanotto, Caterina, Reale, Anna, Zampieri, Michele, Zaza, Alessandra, Ricciardi, Maria Rosaria, Angelini, Daniela Francesca, Tafuri, Agostino, Ottone, Tiziana, Voso, Maria Teresa, Zardo, Giuseppe

“…In this study we analyzed the expression of Yin and Yang 1 protein (YY1), a member of the noncanonical PcG complexes, in AML patient samples and AML cell lines…”
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Tumor Suppressor p16INK4A Regulates Polycomb-mediated DNA Hypermethylation in Human Mammary Epithelial Cells by Reynolds, Paul A., Sigaroudinia, Mahvash, Zardo, Giuseppe, Wilson, Matthew B., Benton, Geoffrey M., Miller, Caroline J., Hong, Chibo, Fridlyand, Jane, Costello, Joseph F., Tlsty, Thea D.

“…Alterations in DNA methylation are important in cancer, but the acquisition of these alterations is poorly understood. Using an unbiased global screen for CpG…”
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Increased PARylation impacts the DNA methylation process in type 2 diabetes mellitus by Zampieri, Michele, Bacalini, Maria Giulia, Barchetta, Ilaria, Scalea, Stefania, Cimini, Flavia Agata, Bertoccini, Laura, Tagliatesta, Stefano, De Matteis, Giovanna, Zardo, Giuseppe, Cavallo, Maria Gisella, Reale, Anna

“…Epigenetic modifications, such as DNA methylation, can influence the genetic susceptibility to type 2 diabetes mellitus (T2DM) and the progression of the…”
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Left-sided early-onset vs late-onset colorectal carcinoma: histologic, clinical, and molecular differences by Pilozzi, Emanuela, Maresca, Carmen, Duranti, Enrico, Giustiniani, Maria Cristina, Catalanotto, Caterina, Lucarelli, Marco, Cogoni, Carlo, Ferri, Mario, Ruco, Luigi, Zardo, Giuseppe

“…Carcinomas of the left colon represent a neoplasm of older patients (late onset), but epidemiologic evidence has been showing an increasing incidence in…”
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Efficiency of expression of transfected genes depends on the cell cycle by Marenzi, S, Adams, R L, Zardo, G, Lenti, L, Reale, A, Caiafa, P

“…Lipofection, a lipid-mediated DNA transfection procedure, was used to transfect synchronized L929 mouse fibroblast cells with a reporter plasmid containing the…”
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