Search Results - "ZANOTTO, Alfeu"

Differential macrophage activation alters the expression profile of NTPDase and ecto-5'-nucleotidase by Zanin, Rafael Fernandes, Braganhol, Elizandra, Bergamin, Letícia Scussel, Campesato, Luís Felipe Ingrassia, Filho, Alfeu Zanotto, Moreira, José Cláudio Fonseca, Morrone, Fernanda Bueno, Sévigny, Jean, Schetinger, Maria Rosa Chitolina, de Souza Wyse, Angela Terezinha, Battastini, Ana Maria Oliveira

“…Macrophages are key elements in the inflammatory process, whereas depending on the micro-environmental stimulation they exhibit a pro-inflammatory…”
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CFL1 expression levels as a prognostic and drug resistance marker in nonsmall cell lung cancer by Castro, Mauro Antonio Alves, Dal‐Pizzol, Felipe, Zdanov, Stephanie, Soares, Marcio, Müller, Carolina Beatriz, Lopes, Fernanda Martins, Zanotto‐Filho, Alfeu, Fernandes, Marilda da Cruz, Moreira, Jose Claudio Fonseca, Shacter, Emily, Klamt, Fábio

“…BACKGROUND: Nonsmall cell lung cancer (NSCLC) is the major determinant of overall cancer mortality worldwide. Despite progress in molecular research, current…”
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Anticancer activity of flavonoids isolated from Achyrocline satureioides in gliomas cell lines by Souza, Priscila Oliveira de, Bianchi, Sara Elis, Figueiró, Fabrício, Heimfarth, Luana, Moresco, Karla Suzana, Gonçalves, Rosângela Mayer, Hoppe, Juliana Bender, Klein, Caroline Peres, Salbego, Christianne Gazzana, Gelain, Daniel Pens, Bassani, Valquíria Linck, Zanotto Filho, Alfeu, Moreira, José Claudio Fonseca

“…Achyrocline satureioides, popularly known as “marcela”, is a medicinal plant found in South America. This plant is rich in flavonoids, which have been reported…”
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Curcumin-loaded lipid-core nanocapsules as a strategy to improve pharmacological efficacy of curcumin in glioma treatment by Zanotto-Filho, Alfeu, Coradini, Karine, Braganhol, Elizandra, Schröder, Rafael, de Oliveira, Cláudia Melo, Simões-Pires, André, Battastini, Ana Maria Oliveira, Pohlmann, Adriana Raffin, Guterres, Sílvia Stanisçuaski, Forcelini, Cassiano Mateus, Beck, Ruy Carlos Ruver, Moreira, José Cláudio Fonseca

“…Curcumin-loaded lipid-core nanocapsules reduce tumor size in animal model of glioma. In this study, we developed curcumin-loaded lipid-core nanocapsules…”
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Comparison between proliferative and neuron-like SH-SY5Y cells as an in vitro model for Parkinson disease studies by Lopes, Fernanda Martins, Schröder, Rafael, Júnior, Mário Luiz Conte da Frota, Zanotto-Filho, Alfeu, Müller, Carolina Beatriz, Pires, André Simões, Meurer, Rosalva Thereza, Colpo, Gabriela Delevati, Gelain, Daniel Pens, Kapczinski, Flávio, Moreira, José Cláudio Fonseca, Fernandes, Marilda da Cruz, Klamt, Fabio

“…Abstract The molecular mechanisms underlying the cellular lost found in the nigrostriatal pathway during the progression of Parkinson's disease (PD) are not…”
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The curry spice curcumin selectively inhibits cancer cells growth in vitro and in preclinical model of glioblastoma by Zanotto-Filho, Alfeu, Braganhol, Elizandra, Edelweiss, Maria Isabel, Behr, Guilherme A, Zanin, Rafael, Schröder, Rafael, Simões-Pires, André, Battastini, Ana Maria Oliveira, Moreira, José Cláudio Fonseca

“…Previous studies suggested that curcumin is a potential agent against glioblastomas (GBMs). However, the in vivo efficacy of curcumin in gliomas remains not…”
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DNA-PKcs restricts Zika virus spreading and is required for effective antiviral response by Patricio, Daniel de Oliveira, Dias, Greicy Brisa Malaquias, Granella, Lucilene Wildner, Trigg, Ben, Teague, Helena Claire, Bittencourt, Dina, Báfica, André, Zanotto-Filho, Alfeu, Ferguson, Brian, Mansur, Daniel Santos

“…Zika virus (ZIKV) is a single-strand RNA mosquito-borne flavivirus with significant public health impact. ZIKV infection induces double-strand DNA breaks…”
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role of two putative nitroreductases, Frm2p and Hbn1p, in the oxidative stress response in Saccharomyces cerevisiae by de Oliveira, Iuri Marques, Zanotto-Filho, Alfeu, Moreira, José Cláudio Fonseca, Bonatto, Diego, Henriques, João Antonio Pêgas

“…The nitroreductase family is comprised of a group of FMN- or FAD-dependent enzymes that are able to metabolize nitrosubstituted compounds using the reducing…”
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Nucleotide receptors control IL-8/CXCL8 and MCP-1/CCL2 secretions as well as proliferation in human glioma cells by Braganhol, Elizandra, Kukulski, Filip, Lévesque, Sébastien A., Fausther, Michel, Lavoie, Elise G., Zanotto-Filho, Alfeu, Bergamin, Leticia S., Pelletier, Julie, Bahrami, Fariborz, Yebdri, Fethia Ben, Fonseca Moreira, José Claudio, Battastini, Ana Maria O., Sévigny, Jean

“…Glioma cells release cytokines to stimulate inflammation that facilitates cell proliferation. Here, we show that Lipopolysaccharide (LPS) treatment could…”
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Proteasome inhibitor MG132 induces selective apoptosis in glioblastoma cells through inhibition of PI3K/Akt and NFkappaB pathways, mitochondrial dysfunction, and activation of p38-JNK1/2 signaling by Zanotto-Filho, Alfeu, Braganhol, Elizandra, Battastini, Ana Maria Oliveira, Moreira, José Cláudio Fonseca

“…Summary Proteasome inhibitors are emerging as a new class of anticancer agents. In this work, we examined the mechanisms underlying cytotoxicity, selectivity…”
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Scavenging and antioxidant potential of physiological taurine concentrations against different reactive oxygen/nitrogen species by Oliveira, Max W.S., Minotto, Juliane B., de Oliveira, Marcos R., Zanotto-Filho, Alfeu, Behr, Guilherme A., Rocha, Ricardo F., Moreira, José C.F., Klamt, Fábio

“…While several studies have been conducted on the antioxidant properties of the β-amino acid taurine, these studies all used concentrations lower than what is…”
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β-Caryophyllene Inhibits Oxaliplatin-Induced Peripheral Neuropathy in Mice: Role of Cannabinoid Type 2 Receptors, Oxidative Stress and Neuroinflammation by Agnes, Jonathan Paulo, dos Santos, Barbara, das Neves, Raquel Nascimento, Luciano, Vitória Maria Marques, Benvenutti, Larissa, Goldoni, Fernanda Capitanio, Schran, Roberta Giusti, Santin, José Roberto, Quintão, Nara Lins Meira, Zanotto-Filho, Alfeu

“…Peripheral neuropathy is an important adverse effect caused by some chemotherapeutic agents, including oxaliplatin (OXA). OXA-induced peripheral neuropathy…”
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Resveratrol-loaded lipid-core nanocapsules treatment reduces in vitro and in vivo glioma growth by Figueiró, Fabrício, Bernardi, Andressa, Frozza, Rudimar L, Terroso, Thatiana, Zanotto-Filho, Alfeu, Jandrey, Elisa H F, Moreira, José Claudio F, Salbego, Christianne G, Edelweiss, Maria I, Pohlmann, Adriana R, Guterres, Sílvia S, Battastini, Ana Maria O

“…The development of novel therapeutic strategies to treat gliomas remains critical as a result of the poor prognoses, inef-. ficient therapies and recurrence…”
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Combined Gene Expression and RNAi Screening to Identify Alkylation Damage Survival Pathways from Fly to Human by Zanotto-Filho, Alfeu, Dashnamoorthy, Ravi, Loranc, Eva, de Souza, Luis H T, Moreira, José C F, Suresh, Uthra, Chen, Yidong, Bishop, Alexander J R

“…Alkylating agents are a key component of cancer chemotherapy. Several cellular mechanisms are known to be important for its survival, particularly DNA repair…”
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Inflammatory landscape of human brain tumors reveals an NFκB dependent cytokine pathway associated with mesenchymal glioblastoma by Zanotto-Filho, Alfeu, PhD, Gonçalves, Rosângela Mayer, Klafke, Karina, Oliveira de Souza, Priscila, Dillenburg, Fabiane Cristine, Carro, Luigi, Gelain, Daniel Pens, Fonseca Moreira, José Cláudio

“…Abstract The tumor microenvironment is being increasingly recognized as a key factor in cancer aggressiveness. In this study, we characterized the inflammatory…”
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Extracellular HSP70 Activates ERK1/2, NF-kB and Pro-Inflammatory Gene Transcription Through Binding with RAGE in A549 Human Lung Cancer Cells by Somensi, Nauana, Brum, Pedro Ozorio, de Miranda Ramos, Vitor, Gasparotto, Juciano, Zanotto-Filho, Alfeu, Rostirolla, Diana Carolina, da Silva Morrone, Maurilio, Moreira, José Claudio Fonseca, Pens Gelain, Daniel

“…Background/Aims: Heat shock protein 70 (HSP70) has been recently described with extracellular actions, where it is actively released in inflammatory…”
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Can electrons travel through actin microfilaments and generate oxidative stress in retinol treated Sertoli cell by de Oliveira, Ramatis Birnfeld, de Bittencourt Pasquali, Matheus Augusto, Filho, Alfeu Zanotto, Dalmolin, Rodrigo Juliani Siqueira, Gelain, Daniel Pens, Gottfried, Carmem, Rodrigues, José Luiz, Klamt, Fábio, Moreira, José Cláudio Fonseca

“…In early reports our research group has demonstrated that 7 μM retinol (vitamin A) treatment leads to many changes in Sertoli cell metabolism, such as…”
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Abstract P5-10-03: Mutant p53 and ERK1/2 MAPK cooperate with the production of TNBC inflammatory secretome by das Neves, Raquel Nascimento, Gorthi, Aparna, Bishop, Alexander James Roy, Filho, Alfeu Zanotto

“…Abstract TP53 is the most frequently mutated gene in most types of human cancer, including breast cancer. The triple-negative breast cancer (TNBC) subtype in…”
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Gastrin-releasing Peptide Receptor Antagonist Effects on an Animal Model of Sepsis by Dal-Pizzol, Felipe, Di Leone, Luciane Pons, Ritter, Cristiane, Martins, Marcio Rodrigo, Reinke, Adalisa, Pens Gelain, Daniel, Zanotto-Filho, Alfeu, de Souza, Luiz Fernando, Andrades, Michael, Barbeiro, Denise Frediani, Bernard, Elena Aida, Cammarota, Martin, Bevilaqua, Lia R. M, Soriano, Francisco Garcia, Claudio, Jose, Moreira, Fonseca, Roesler, Rafael, Schwartsmann, Gilberto

“…Several new therapeutic strategies have been described for the treatment of sepsis, but to date none are related to alterations in the…”
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Boldine induces cell cycle arrest and apoptosis in T24 human bladder cancer cell line via regulation of ERK, AKT, and GSK-3β by Gerhardt, Daniéli, Ph.D, Bertola, Gabriela, Dietrich, Fabrícia, M.Sc, Figueiró, Fabrício, PharmD, Zanotto-Filho, Alfeu, Ph.D, Moreira Fonseca, José Cláudio, Ph.D, Morrone, Fernanda Bueno, Ph.D, Barrios, Carlos Henrique, Ph.D, Battastini, Ana Maria O., Ph.D, Salbego, Christianne G., Ph.D

“…Abstract Objective Bladder cancer is one of the most prevalent genitourinary malignancies. Despite active chemotherapy regimens, patients with bladder cancer…”
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