Search Results - "ZANNIS, VASSILIS I"

MicroRNA-370 controls the expression of MicroRNA-122 and Cpt1α and affects lipid metabolism[S] by Iliopoulos, Dimitrios, Drosatos, Konstantinos, Hiyama, Yaeko, Goldberg, Ira J., Zannis, Vassilis I.

“…We previously observed that treatment of mice with a dominant negative form of cJun (dn-cJun) increased the expression of genes involved in lipid metabolism…”
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Role of apoA-I, ABCA1, LCAT, and SR-BI in the biogenesis of HDL by ZANNIS, Vassilis I, CHRONI, Angeliki, KRIEGER, Manly

“…The concentration, composition, shape, and size of plasma high-density lipoprotein (HDL) are determined by numerous proteins that influence its biogenesis,…”
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High-density lipoprotein attenuates Th1 and th17 autoimmune responses by modulating dendritic cell maturation and function by Tiniakou, Ioanna, Drakos, Elias, Sinatkas, Vaios, Van Eck, Miranda, Zannis, Vassilis I, Boumpas, Dimitrios, Verginis, Panayotis, Kardassis, Dimitris

“…Aberrant levels and function of the potent anti-inflammatory high-density lipoprotein (HDL) and accelerated atherosclerosis have been reported in patients with…”
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Effect of apoA-I Mutations in the Capacity of Reconstituted HDL to Promote ABCG1-Mediated Cholesterol Efflux by Daniil, Georgios, Zannis, Vassilis I, Chroni, Angeliki

“…ATP binding cassette transporter G1 (ABCG1) mediates the cholesterol transport from cells to high-density lipoprotein (HDL), but the role of apolipoprotein A-I…”
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Pathway of biogenesis of apolipoprotein E-containing HDL in vivo with the participation of ABCA1 and LCAT by Kypreos, Kyriakos E, Zannis, Vassilis I

“…We have investigated the ability of apoE (apolipoprotein E) to participate in the biogenesis of HDL (high-density lipoprotein) particles in vivo using…”
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Regulation of Human Apolipoprotein M Gene Expression by Orphan and Ligand-dependent Nuclear Receptors by Mosialou, Ioanna, Zannis, Vassilis I., Kardassis, Dimitris

“…Apolipoprotein M (apoM) plays an important role in the biogenesis and the metabolism of anti-atherogenic HDL particles in plasma and is expressed primarily in…”
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ApoA-IV promotes the biogenesis of apoA-IV-containing HDL particles with the participation of ABCA1 and LCAT[S] by Duka, Adelina, Fotakis, Panagiotis, Georgiadou, Dimitra, Kateifides, Andreas, Tzavlaki, Kalliopi, von Eckardstein, Leonard, Stratikos, Efstratios, Kardassis, Dimitris, Zannis, Vassilis I.

“…The objective of this study was to establish the role of apoA-IV, ABCA1, and LCAT in the biogenesis of apoA-IV-containing HDL (HDL-A-IV) using different mouse…”
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apolipoprotein E4 fragment can promote intracellular accumulation of amyloid peptide beta 42 by Dafnis, Ioannis, Stratikos, Efstratios, Tzinia, Athina, Tsilibary, Effie C, Zannis, Vassilis I, Chroni, Angeliki

“…J. Neurochem. (2010) 115, 873-884. ABSTRACT: Apolipoprotein E (apoE) plays a crucial role in lipid transport in circulation and the brain. The apoE4 isoform is…”
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Biophysical analysis of apolipoprotein E3 variants linked with development of type III hyperlipoproteinemia by Georgiadou, Dimitra, Chroni, Angeliki, Vezeridis, Alexander, Zannis, Vassilis I, Stratikos, Efstratios

“…Apolipoprotein E (apoE) is a major protein of the lipoprotein transport system that plays important roles in lipid homeostasis and protection from…”
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Inflammatory Signaling Pathways Regulating ApoE Gene Expression in Macrophages by Gafencu, Anca V., Robciuc, Marius R., Fuior, Elena, Zannis, Vassilis I., Kardassis, Dimitris, Simionescu, Maya

“…The atheroprotective role of apolipoprotein E (apoE) is well established. During inflammation, expression of apoE in macrophages is reduced leading to enhanced…”
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apoE3[K146N/R147W] acts as a dominant negative apoE form that prevents remnant clearance and inhibits the biogenesis of HDL[S] by Fotakis, Panagiotis, Vezeridis, Alexander, Dafnis, Ioannis, Chroni, Angeliki, Kardassis, Dimitris, Zannis, Vassilis I.

“…The K146N/R147W substitutions in apoE3 were described in patients with a dominant form of type III hyperlipoproteinemia. The effects of these mutations on the…”
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Specific Mutations in ABCA1 Have Discrete Effects on ABCA1 Function and Lipid Phenotypes Both In Vivo and In Vitro by Singaraja, Roshni R, Visscher, Henk, James, Erick R, Chroni, Angeliki, Coutinho, Jonathan M, Brunham, Liam R, Kang, Martin H, Zannis, Vassilis I, Chimini, Giovanna, Hayden, Michael R

“…Mutations in ATP-binding cassette transporter A1 (ABCA1) cause Tangier disease and familial hypoalphalipoproteinemia, resulting in low to absent plasma…”
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Naturally occurring and bioengineered apoA-I mutations that inhibit the conversion of discoidal to spherical HDL: the abnormal HDL phenotypes can be corrected by treatment with LCAT by Koukos, Georgios, Chroni, Angeliki, Duka, Adelina, Kardassis, Dimitris, Zannis, Vassilis I

“…In the present study we have used adenovirus-mediated gene transfer of apoA-I (apolipoprotein A-I) mutants in apoA-I-/- mice to investigate how structural…”
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Molecular etiology of a dominant form of type III hyperlipoproteinemia caused by R142C substitution in apoE4[S] by Vezeridis, Alexander M., Drosatos, Konstantinos, Zannis, Vassilis I.

“…We have used adenovirus-mediated gene transfer in apolipoprotein (apo)E−/− mice to elucidate the molecular etiology of a dominant form of type III…”
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Using adenovirus-mediated gene transfer to study the effect of myeloperoxidase on plasma lipid levels, HDL structure and functionality in mice expressing human apoA-I forms by Dalakoura-Karagkouni, Katerina, Tiniakou, Ioanna, Zannis, Vassilis I., Kardassis, Dimitris

“…Apolipoprotein A-I (apoA-I), the main protein component of High-Density Lipoprotein (HDL), is modified in plasma and the arterial wall by various enzymes…”
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Alteration of negatively charged residues in the 89 to 99 domain of apoA-I affects lipid homeostasis and maturation of HDL[S] by Kateifides, Andreas K., Gorshkova, Irina N., Duka, Adelina, Chroni, Angeliki, Kardassis, Dimitris, Zannis, Vassilis I.

“…Abstract In this study, we investigated the role of positively and negatively charged amino acids within the 89-99 region of apolipoprotein A-I (apoA-I), which…”
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Cross-Linking and Lipid Efflux Properties of ApoA-I Mutants Suggest Direct Association between ApoA-I Helices and ABCA1 by Chroni, Angeliki, Liu, Tong, Fitzgerald, Michael L, Freeman, Mason W, Zannis, Vassilis I

“…To explore the functional interactions between apoA-I and ABCA1, we correlated the cross-linking properties of several apoA-I mutants with their ability to…”
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Cross-inhibition of SR-BI- and ABCA1-mediated cholesterol transport by the small molecules BLT-4 and glyburide by Nieland, Thomas J F, Chroni, Angeliki, Fitzgerald, Michael L, Maliga, Zoltan, Zannis, Vassilis I, Kirchhausen, Tomas, Krieger, Monty

“…Scavenger receptor class B type I (SR-BI) and ABCA1 are structurally dissimilar cell surface proteins that play key roles in HDL metabolism. SR-BI is a…”
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The Effects of Mutations in Helices 4 and 6 of ApoA-I on Scavenger Receptor Class B Type I (SR-BI)-mediated Cholesterol Efflux Suggest That Formation of a Productive Complex between Reconstituted High Density Lipoprotein and SR-BI Is Required for Efficient Lipid Transport by Liu, Tong, Krieger, Monty, Kan, Horng-Yuan, Zannis, Vassilis I

“…We have studied the effects of mutations in apoA-I on reconstituted high density lipoprotein (HDL) particle (rHDL(apoA-I)) binding to and cholesterol efflux…”
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Identification of the Molecular Target of Small Molecule Inhibitors of HDL Receptor SR-BI Activity by Nieland, Thomas J. F, Shaw, Jared T, Jaipuri, Firoz A, Duffner, Jay L, Koehler, Angela N, Banakos, Sotirios, Zannis, Vassilis I, Kirchhausen, Tomas, Krieger, Monty

“…Scavenger receptor, class B, type I (SR-BI), controls high-density lipoprotein (HDL) metabolism by mediating cellular selective uptake of lipids from HDL…”
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