Secretory immune response in patients with intestinal amoebiasis

Secretory immune response in patients with intestinal amoebiasis

The secretory immune response in saliva from intestinal amoebiasis patients against antigens obtained from Entamoeba histolytica membranes was studied. Western blot analysis indicated that patient saliva contains secretory IgA antibodies against antigens with molecular masses ranging from 170 to 24 ...

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Bibliographic Details
Published in:Parasite immunology Vol. 20; no. 10; pp. 503 - 507
Main Authors: ORTIZ‐ORTIZ, LIBRADO, MORA, NANCY, ZAMBRANO‐VILLA, SEGIO A., CARRERO, JULIO CÉSAR, SÁNCHEZ‐ZERPA, MARÍA, OSUNA, ANTONIO, ROSALES‐BORJAS, DISNEY M.
Format: Journal Article
Language:English
Published: Oxford, U.K. and Cambridge, USA Blackwell Science Ltd 01-10-1998
Subjects:
Animals
Antibodies, Protozoan - analysis
Antigens, Protozoan - isolation & purification
Entamoeba histolytica
Entamoeba histolytica - immunology
Entamoebiasis - immunology
Humans
Immunoblotting
Immunoglobulin A, Secretory - analysis
intestinal amoebiasis
Intestinal Diseases, Parasitic - immunology
invasive amoebiasis
membrane antigens
Membrane Proteins - isolation & purification
Protozoan Proteins - isolation & purification
saliva
Saliva - immunology
sIgA
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Summary:The secretory immune response in saliva from intestinal amoebiasis patients against antigens obtained from Entamoeba histolytica membranes was studied. Western blot analysis indicated that patient saliva contains secretory IgA antibodies against antigens with molecular masses ranging from 170 to 24 kDa, some of which were also recognized by saliva from healthy subjects. However, antigens of 170, 125, 46 and 37 kDa are recognized more frequently (> 90%) by the secretory IgA from patients with intestinal amoebiasis than by that from healthy subjects (< 10%).
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ISSN:0141-9838
1365-3024
DOI:10.1046/j.1365-3024.1998.00173.x