Search Results - "ZAHARKO, D"

Augmentation of natural killer activity, induction of IFN and development tumor immunity during the successful treatment of established murine renal cancer using flavone acetic acid and IL-2 by Hornung, RL, Back, TC, Zaharko, DS, Urba, WJ, Longo, DL, Wiltrout, RH

“…The investigational drug flavone acetic acid (FAA) has been previously shown to systemically augment NK activity in vivo in normal mice within 24 h of i.p. or…”
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Liposomes and Local Hyperthermia: Selective Delivery of Methotrexate to Heated Tumors by Weinstein, J. N., Magin, R. L., Yatvin, M. B., Zaharko, D. S.

“…Liposomes with phase transitions a few degrees above physiological temperature delivered more than four times as much methotrexate to murine tumors heated to…”
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Differences in DNA damage produced by incorporation of 5-aza-2'-deoxycytidine or 5,6-dihydro-5-azacytidine into DNA of mammalian cells by COVEY, J. M, D'INCALCI, M, TILCHEN, E. J, ZAHARKO, D. S, KOHN, K. W

“…The effects of 5-aza-2'-deoxycytidine (aza-dCyd) and 5,6-dihydro-5-azacytidine (H2-aza-Cyd) on the integrity of DNA from several mammalian cell lines were…”
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Chloroquinoxaline sulfonamide : a sulfanilamide antitumor agent entering clinical trials by FISHERMAN, J. S, OSBORN, B. L, CHUN, H. G, PLOWMAN, J, SMITH, A. C, CHRISTIAN, M. C, ZAHARKO, D. S, SHOEMAKER, R. H

“…Chloroquinoxaline sulfonamide (CQS) has been developed to the clinical trial stage based on its activity in the Human Tumor Colony Forming Assay (HTCFA). In…”
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DNA alkali-labile sites induced by incorporation of 5-aza-2'-deoxycytidine into DNA of mouse leukemia L1210 cells by DINCALCI, M, COVEY, J. M, ZAHARKO, D. S, KOHN, K. W

“…The effects of 5-aza-2'-deoxycytidine on DNA in mouse L1210 leukemia cells were investigated using the alkaline elution technique. By comparing the DNA elution…”
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Modification of chemotherapeutic effects on L1210 cells using hematoporphyrin and light by CREEKMORE, S. P, ZAHARKO, D. S

“…Tissue culture experiments were done to evaluate the possibility of modifying the response curves of phenylalanine mustard (LPAM) and actinomycin D on L1210…”
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Flavone acetic acid (LM 975, NSC 347512): a novel antitumor agent by O'DWYER, P. J, SHOEMAKER, D, LEYLAND-JONES, ZAHARKO, D. S, GRIESHABER, C, PLOWMAN, J, CORBETT, T, VALERIOTE, F, KING, S. A, CRADOCK, J, HOTH, D. F

“…Flavone acetic acid (FAA) is a synthetic flavonoid compound which has recently begun clinical trials as an antitumor agent based on its striking activity in…”
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Cyclopentenyl cytosine : interspecies predictions based on rodent plasma and urine kinetics by ZAHARKO, D. S, KELLEY, J. A, TOMASZEWSKI, J. E, HEGEDUS, L, HARTMAN, N. R

“…A hybrid compartmental-physiological model for cyclopentenyl cytosine (CPE-C) is designed on the basis of early limited rodent pharmacokinetic data…”
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Methotrexate pharmacokinetics by Bischoff, K B, Dedrick, R L, Zaharko, D S, Longstreth, J A

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Could interspecies differences in the protein binding of flavone acetic acid contribute to the failure to predict lack of efficacy in patients? by CASSIDY, J, KERR, D. J, SETANOIANS, A, ZAHARKO, D. S, KAYE, S. B

“…We investigated the differences in plasma protein binding of flavone acetic acid (FAA) in mice and men in an attempt to explain the inter-species differences…”
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Experimental chemotherapy (L1210) with 5-aza-2'-deoxycytidine in combination with pyran copolymer (MVE-4), an immune adjuvant by Zaharko, D S, Covey, J M, Muneses, C C

“…The life-span of CDF1 (BALB/c X DBA/2)F1 mice that received intraperitoneal implants with 10(5) L1210 tumor cells was prolonged to 23 days (compared to 8 days…”
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Studies of a simplified plasma insulin immunoassaay using cellulose powder by Zaharko, D S, Beck, L V

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Immunological concepts and the combination of cyclophosphamide with 5-aza-2'-deoxycytidine on L1210 in vivo by Zaharko, D S

“…Experiments were designed to demonstrate the synergism of low dose cyclophosphamide (CY), (15 mg/kg or 45 mg/M2) in combination with 5-aza-2'deoxycytidine…”
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Modulation of deoxycytidine metabolism in vivo with high-dose thymidine in mice by Zaharko, D S, Covey, J M

“…The question of whether selective biochemical modulation of deoxycytidine (dCyd) metabolism by thymidine (dThd) could be quantitated in vivo was addressed…”
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Transport and binding of methotrexate in vivo by Dedrick, R L, Zaharko, D S, Lutz, R J

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Potential roles for preclinical pharmacology in phase I clinical trials by Collins, J M, Zaharko, D S, Dedrick, R L, Chabner, B A

“…Concepts elucidated from preclinical pharmacology studies have made a substantial impact on the clinical use of anticancer drugs. However, the majority of…”
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Relative toxicity of methotrexate in several tissues of mice bearing Lewis lung carcinoma by Zaharko, D S, Dedrick, R L, Peale, A L, Drake, J C, Lutz, R J

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Preliminary model for methotrexate pharmacokinetics by Bischoff, K B, Dedrick, R L, Zaharko, D S

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Treatment of solid L1210 murine tumors with local hyperthermia and temperature-sensitive liposomes containing methotrexate by Weinstein, J N, Magin, R L, Cysyk, R L, Zaharko, D S

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The stimulation of insulin secretion in dogs by tris (hydroxymethyl) aminomethane by Zaharko, D S

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