Search Results - "ZACHARCHUK, C. M"

Lack of a role for Jun kinase and AP-1 in Fas-induced apoptosis by Lenczowski, Joi M., Domínguez, Lourdes, Eder, Astrid M., King, Leslie B., Zacharchuk, Charles M., Ashwell, Jonathan D.

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Dominant negative mutant of c-Jun inhibits NF-AT transcriptional activity and prevents IL-2 gene transcription by Petrak, D, Memon, SA, Birrer, MJ, Ashwell, JD, Zacharchuk, CM

“…Expression of the transcription complex AP-1, composed of Jun and Fos family members, can be induced by a variety of stimuli. In lymphocytes, AP-1…”
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Mechanism of macrophage-mediated cytotoxicity: production of a soluble cytotoxic factor by Drysdale, BE, Zacharchuk, CM, Shin, HS

“…Peritoneal macrophages from C3HeB/FeJ mice became cytotoxic for 6C3HED lymphosarcoma cells, P815 mastocytoma cells, and L-929 fibroblasts when treated with the…”
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A simple assay for examining the effect of transiently expressed genes on programmed cell death by Memon, Sarfraz A., Petrak, Daniel, Belen Moreno, M., Zacharchuk, Charles M.

“…Programmed cell death (PCD) has been observed in a wide variety of cell types in response to physiologic signals or types of stress. How these stimuli trigger…”
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Target Cell Lysis by CTL Granule Exocytosis Is Independent of ICE/Ced-3 Family Proteases by Sarin, Apurva, Williams, Mark S., Alexander-Miller, Martha A., Berzofsky, Jay A., Zacharchuk, Charles M., Henkart, Pierre A.

“…Activation of ICE/Ced-3 family proteases (caspases) has been proposed to mediate both the granule exocytosis and Fas–Fas ligand pathways of rapid target cell…”
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Bcl-2 blocks glucocorticoid- but not Fas- or activation-induced apoptosis in a T cell hybridoma by Memon, SA, Moreno, MB, Petrak, D, Zacharchuk, CM

“…Overexpression of Bcl-2 can prevent or markedly delay cell death induced by a variety of apoptotic stimuli. Although Fas and Fas ligand (FasL) interactions…”
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Thymocyte activation and death: a mechanism for molding the T cell repertoire by Zacharchuk, C M, Merćep, M, Ashwell, J D

“…The programmed death of thymocytes and T cells was studied. Injection of anti-TCR antibodies into adult mice caused the specific deletion of CD4+ CD8+…”
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Role of Ly-6A/E and T cell receptor-zeta for IL-2 production. Phosphatidylinositol-anchored Ly-6A/E antagonizes T cell receptor- mediated IL-2 production by a zeta-independent pathway by Codias, EK, Fleming, TJ, Zacharchuk, CM, Ashwell, JD, Malek, TR

“…Ly-6A/E molecules were originally implicated in regulation of T cell activation because anti-Ly-6A/E mAb induce IL-2 production. More recently we have shown…”
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Macrophage-Mediated Cytotoxicity: Role of a Soluble Macrophage Cytotoxic Factor Similar to Lymphotoxin and Tumor Necrosis Factor by Zacharchuk, Charles M., Drysdale, Beth-Ellen, Mayer, Manfred M., Shin, Hyun S.

“…Guinea pig peritoneal macrophages, when activated for cytotoxicity by the calcium ionophore A23187 or lipopolysaccharide, produce a cytotoxic factor…”
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Variations in thymocyte susceptibility to clonal deletion during ontogeny. Implications for neonatal tolerance by Zacharchuk, CM, Mercep, M, June, CH, Weissman, AM, Ashwell, JD

“…Activation of immature thymocytes via the TCR results in programmed cell death and clonal deletion. We have examined thymocytes from mice of different ages and…”
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Programmed T lymphocyte death. Cell activation- and steroid-induced pathways are mutually antagonistic by Zacharchuk, CM, Mercep, M, Chakraborti, PK, Simons, SS, Jr, Ashwell, JD

“…Both cellular activation signals and exposure to glucocorticoids such as dexamethasone (Dex) cause programmed cell death in T cell hybridomas. When cells were…”
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Apoptosis signaling pathways in normal T cells. Differential activity of Bcl-2 and IL-1 beta -converting enzyme family protease inhibitors on glucocorticoid- and Fas-mediated cytotoxicity by Moreno, M B, Memon, SA, Zacharchuk, C M

“…Fas-mediated apoptosis plays an important role in regulating the immune response in peripheral T cells. Restimulation of T cell blasts up-regulates Fas and Fas…”
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Effect of trypsin on mouse mammary tumor virus by Sheffield, J B, Zacharchuk, C M, Taraschi, N, Daly, T M

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Recombinant mouse Bcl-2(1-203). Two domains connected by a long protease-sensitive linker by Vance, B A, Zacharchuk, C M, Segal, D M

“…Bcl-2 is a cytoplasmic integral membrane protein with potent anti-apoptotic activity but whose mechanism of action is poorly understood. The purpose of this…”
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H-2 Restriction: Independent Recognition of H-2 and Foreign Antigen by a Single Receptor by Siliciano, Robert F., Zacharchuk, Charles M., Shin, Hyun S.

“…We describe two situations in which the recognition of hapten can compensate for the lack of recognition of appropriate H-2 gene products in hapten-specific,…”
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Bispecific antibodies retarget murine T cell cytotoxicity against syngeneic breast cancer in vitro and in vivo by MORENO, M. B, TITUS, J. A, COLE, M. S, YUN TSO, J, NHAT LE, PAIK, C. H, BAKACS, T, ZACHARCHUK, C. M, SEGAL, D. M, WUNDERLICH, J. R

“…Bispecific antibodies with specificity for CD3 and a tumor antigen can redirect cytolytic T cells to kill tumor targets, regardless of their natural…”
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Apoptosis signaling pathways in normal T cells: differential activity of Bcl-2 and IL-1beta-converting enzyme family protease inhibitors on glucocorticoid- and Fas-mediated cytotoxicity by Moreno, MB, Memon, SA, Zacharchuk, CM

“…Fas-mediated apoptosis plays an important role in regulating the immune response in peripheral T cells. Restimulation of T cell blasts up-regulates Fas and Fas…”
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A bispecific antibody prolongs survival in mice bearing lung metastases of syngeneic mammary adenocarcinoma by Bakács, T, Lee, J, Moreno, M B, Zacharchuk, C M, Cole, M S, Tso, J Y, Paik, C H, Ward, J M, Segal, D M

“…In the present study we tested whether T cells retargeted with a bispecific antibody (bsAb) could block the growth of lung metastases of syngeneic mammary…”
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Bosutinib (SKI-606), a dual Src/Abl tyrosine kinase inhibitor: Preliminary results from a phase 1 study in patients with advanced malignant solid tumors by Messersmith, W. A., Krishnamurthi, S., Hewes, B. A., Zacharchuk, C. M., Abbas, R., Martins, P., Dowling, E., Volkert, A., Martin, E., Daud, A. I.

“…Abstract only 3552 Background: Bosutinib (SKI-606) is a potent, low molecular weight, orally active, competitive inhibitor of both Src and Abl tyrosine…”
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Do CTL kill target cells by inducing apoptosis? by Henkart, Pierre A., Williams, Mark S., Zacharchuk, Charles M., Sarin, Apurva

“…Inhibitors of ICE-family proteases (caspases) block many examples of apoptotic cell deathin vivoandin vitro, including multiple apoptotic stimuli for T…”
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