Search Results - "Závodszky, P."

Structural differences between mesophilic, moderately thermophilic and extremely thermophilic protein subunits: results of a comprehensive survey by Szilágyi, András, Závodszky, Péter

“…Background: Proteins from thermophilic organisms usually show high intrinsic thermal stability but have structures that are very similar to their mesophilic…”
Get full text

The Twilight Zone between Protein Order and Disorder by Szilagyi, A, Gyoerffy, D, Zavodszky, P

“…The amino acid composition of intrinsically disordered proteins and protein segments characteristically differs from that of ordered proteins. This observation…”
Get full text

Adjustment of Conformational Flexibility is a Key Event in the Thermal Adaptation of Proteins by Zavodszky, Peter, Kardos, Jozsef, Svingor, Adam, Petsko, Gregory A.

“…3-Isopropylmalate dehydrogenase (IPMDH, E.C. 1.1.1.85) from the thermophilic bacterium Thermus thermophilus HB8 is homologous to IPMDH from the mesophilic…”
Get full text

Quantitative characterization of the autoactivation steps of MASP-1 and -2: Toward a kinetic model of lectin pathway activation by Dobó, J., Megyeri, M., Szilágyi, K., Harmat, V., Závodszky, P., Gál, P.

Get full text

Crystal structure of MASP-2 in complex with a highly selective phage display evolved inhibitor by Harmat, V., Héja, I., Menyhárd, K., Dobó, J., Závodszky, P., Gál, P., Pál, G.

Get full text

Mechanism of the activation of the lectin pathway by Gál, P., Héja, D., Kocsis, A., Szilágyi, K., Dobó, J., Závodszky, P., Pál, G.

Get full text

A better enzyme to cope with cold. Comparative flexibility studies on psychrotrophic, mesophilic, and thermophilic IPMDHs by Svingor, A, Kardos, J, Hajdú, I, Németh, A, Závodszky, P

“…3-isopropylmalate dehydrogenase (IPMDH) from the psychrotrophic bacterium Vibrio sp. I5 has been expressed in Escherichia coli and purified. This cold-adapted…”
Get full text

New type of interaction between the SARAH domain of the tumour suppressor RASSF1A and its mitotic kinase Aurora A by Szimler, T., Gráczer, É., Györffy, D., Végh, B., Szilágyi, A., Hajdú, I., Závodszky, P., Vas, M.

“…The tumour suppressor protein RASSF1A is phosphorylated by Aurora A kinase, thereby impairing its tumour suppressor function. Consequently, inhibiting the…”
Get full text

The Role of the Individual Domains in the Structure and Function of the Catalytic Region of a Modular Serine Protease, C1r by Kardos, Jozsef, Gal, Peter, Szilagyi, Laszlo, Thielens, Nicole M, Szilagyi, Katalin, Lorincz, Zsolt, Kulcsar, Peter, Graf, Laszlo, Arlaud, Gerard J, Zavodszky, Peter

“…The first enzymatic event in the classical pathway of complement activation is autoactivation of the C1r subcomponent of the C1 complex. Activated C1r then…”
Get full text

Disulfide-Linked Propeptides Stabilize the Structure of Zymogen and Mature Pancreatic Serine Proteases by Kardos, József, Bódi, Árpád, Závodszky, Péter, Venekei, István, Gráf, László

“…Chymotrypsinogen and proelastase 2 are the only pancreatic proteases with propeptides that remain attached to the active enzyme via a disulfide bridge. It is…”
Get full text

High frequency recombination between homologous baculoviruses in cell culture by Hajos, J.P, Pijnenburg, J, Usmany, M, Zuidema, D, Zavodszky, P, Vlak, J.M

“…The frequency of recombination between homologous baculoviruses was investigated in cell culture upon coinfection with two Autographa californica…”
Get full text

Serum Albumin–Lipid Membrane Interaction Influencing the Uptake of Porphyrins by Galántai, Rita, Bárdos-Nagy, Irén, Módos, Károly, Kardos, József, Závodszky, Péter, Fidy, Judit

“…It is frequently observed in pharmaceutical practice that entrapped substances are lost rapidly when liposomes are used as carriers to introduce substances…”
Get full text

Mirror image mutations reveal the significance of an intersubunit ion cluster in the stability of 3-isopropylmalate dehydrogenase by Németh, Attila, Svingor, Ádám, Pócsik, Márta, Dobó, József, Magyar, Csaba, Szilágyi, András, Gál, Péter, Závodszky, Péter

“…The comparison of the three-dimensional structures of thermophilic ( Thermus thermophilus) and mesophilic ( Escherichia coli) 3-isopropylmalate dehydrogenases…”
Get full text

Structure and function of the serine-protease subcomponents of C1: protein engineering studies by Gal, P, Zavodszky, P

“…Our protein engineering studies on human C1r and C1s revealed important characteristics of the individual domains of these multidomain serine-proteases, and…”
Get full text

Relationship between thermal stability and 3-D structure in a homology model of 3-isopropylmalate dehydrogenase from Escherichia coli by Magyar, Csaba, Szilágyi, András, Závodszky, Péter

“…To reveal the structural basis of the increased thermal stability of 3-isopropylmalate dehydrogenase (IPMDH) from Thermus thermophilus, an extreme thermophile,…”
Get full text

Dissociation and re-association properties of the dimerization domains of MASP-1 and MASP-2 indicate tight interaction but slow dimer formation by Dobó, J., Paréj, K., Donáth, N., Závodszky, P., Gál, P.

Get full text

Recombination of baculovirus DNA following lipofection of insect larvae by Hajos, J.P, Zuidema, D, Kulcsar, P, Heldens, J.G.M, Zavodszky, P, Vlak, J.M

“…By injection of a liposomal complex containing baculovirus DNA directly into the hemocoel of insect larvae a polyhedrosis disease was induced. After…”
Get full text

Functional effects of domain deletions in a multidomain serine protease, C1r by Cseh, S, Gál, P, Sárvári, M, Dobó, J, Lörincz, Z, Schumaker, V N, Závodszky, P

“…The C1r subcomponent of the first component of complement is a complex, multidomain glycoprotein containing five regulatory or binding modules in addition to…”
Get full text

MASP-1 induces inflammatory cytokine production in monocytes by Paréj, K., Sándor, N., Dobó, J., Závodszky, P., Bajtay, Z., Gál, P.

Get full text

Baculovirus-mediated trans-epithelial transport of proteins in infected caterpillars by Sarvari, M, Zavodszky, P, Molnar, K, Low, P, Sass, M

“…M Sarvari, P Zavodszky, K Molnar, P Low and M Sass Institute of Enzymology, Hungarian Academy of Sciences, Budapest, Hungary. Baculovirus-mediated abnormal…”
Get full text