Search Results - "Zádori, Zoltán S."

Interactions between NSAIDs, opioids and the gut microbiota - Future perspectives in the management of inflammation and pain by Zádori, Zoltán S., Király, Kornél, Al-Khrasani, Mahmoud, Gyires, Klára

“…The composition of intestinal microbiota is influenced by a number of factors, including medications, which may have a substantial impact on host physiology…”
Get full text

Role of Cannabinoids in Gastrointestinal Mucosal Defense and Inflammation by Gyires, Klára, Zádori, Zoltán S

“…Modulating the activity of the endocannabinoid system influences various gastrointestinal physiological and pathophysiological processes, and cannabinoid…”
Get full text

Glycine transporter inhibitors: A new avenue for managing neuropathic pain by Al-Khrasani, Mahmoud, Mohammadzadeh, Amir, Balogh, Mihály, Király, Kornél, Barsi, Szilvia, Hajnal, Benjamin, Köles, László, Zádori, Zoltán S., Harsing, Laszlo G.

“…•Review of recent data on GlyT inhibitors in neuropathic pain (NP) treatment.•Discussion of the possible mechanisms of action of GlyT inhibitors.•GlyT…”
Get full text

The Acute Antiallodynic Effect of Tolperisone in Rat Neuropathic Pain and Evaluation of Its Mechanism of Action by Lakatos, Péter P., Karádi, Dávid Árpád, Galambos, Anna Rita, Essmat, Nariman, Király, Kornél, Laufer, Rudolf, Geda, Orsolya, Zádori, Zoltán S., Tábi, Tamás, Al-Khrasani, Mahmoud, Szökő, Éva

“…Current treatment approaches to manage neuropathic pain have a slow onset and their use is largely hampered by side-effects, thus there is a significant need…”
Get full text

A comprehensive time course and correlation analysis of indomethacin-induced inflammation, bile acid alterations and dysbiosis in the rat small intestine by Lázár, Bernadette, László, Szilvia B., Hutka, Barbara, Tóth, András S., Mohammadzadeh, Amir, Berekméri, Eszter, Ágg, Bence, Balogh, Mihály, Sajtos, Viktor, Király, Kornél, Al-Khrasani, Mahmoud, Földes, Anna, Varga, Gábor, Makra, Nóra, Ostorházi, Eszter, Szabó, Dóra, Ligeti, Balázs, Kemény, Ágnes, Helyes, Zsuzsanna, Ferdinandy, Péter, Gyires, Klára, Zádori, Zoltán S.

“…[Display omitted] It has been proposed that changes in microbiota due to nonsteroidal anti-inflammatory drugs (NSAIDs) alter the composition of bile, and…”
Get full text

Modulation of excitatory neurotransmission by neuronal/glial signalling molecules: interplay between purinergic and glutamatergic systems by Köles, László, Kató, Erzsébet, Hanuska, Adrienn, Zádori, Zoltán S., Al-Khrasani, Mahmoud, Zelles, Tibor, Rubini, Patrizia, Illes, Peter

“…Glutamate is the main excitatory neurotransmitter of the central nervous system (CNS), released both from neurons and glial cells. Acting via ionotropic (NMDA,…”
Get full text

On the Role of Peripheral Sensory and Gut Mu Opioid Receptors: Peripheral Analgesia and Tolerance by Fürst, Susanna, Zádori, Zoltán S, Zádor, Ferenc, Király, Kornél, Balogh, Mihály, László, Szilvia B, Hutka, Barbara, Mohammadzadeh, Amir, Calabrese, Chiara, Galambos, Anna Rita, Riba, Pál, Romualdi, Patrizia, Benyhe, Sándor, Timár, Júlia, Schmidhammer, Helmut, Spetea, Mariana, Al-Khrasani, Mahmoud

“…There is growing evidence on the role of peripheral µ-opioid receptors (MORs) in analgesia and analgesic tolerance. Opioid analgesics are the mainstay in the…”
Get full text

Shedding Light on the Pharmacological Interactions between μ-Opioid Analgesics and Angiotensin Receptor Modulators: A New Option for Treating Chronic Pain by Király, Kornél, Karádi, Dávid Á, Zádor, Ferenc, Mohammadzadeh, Amir, Galambos, Anna Rita, Balogh, Mihály, Riba, Pál, Tábi, Tamás, Zádori, Zoltán S, Szökő, Éva, Fürst, Susanna, Al-Khrasani, Mahmoud

“…The current protocols for neuropathic pain management include µ-opioid receptor (MOR) analgesics alongside other drugs; however, there is debate on the…”
Get full text

Pharmacological Evidence on Augmented Antiallodynia Following Systemic Co-Treatment with GlyT-1 and GlyT-2 Inhibitors in Rat Neuropathic Pain Model by Mohammadzadeh, Amir, Lakatos, Péter P, Balogh, Mihály, Zádor, Ferenc, Karádi, Dávid Árpád, Zádori, Zoltán S, Király, Kornél, Galambos, Anna Rita, Barsi, Szilvia, Riba, Pál, Benyhe, Sándor, Köles, László, Tábi, Tamás, Szökő, Éva, Harsing, Jr, Laszlo G, Al-Khrasani, Mahmoud

“…The limited effect of current medications on neuropathic pain (NP) has initiated large efforts to develop effective treatments. Animal studies showed that…”
Get full text

Is an intraoperative liver function assessment possible? Application of the 13C-methacetin-breath-test during major liver resections – a pilot study by Makridis, Georgios, Reese, Tim, Zádori, Zoltán S., Suling, Anna I., Stark, Maria, Horling, Katja, Brüning, Roland, Schneider, Martin A., Beumer, Michael, Oldhafer, Karl J.

“…As prevention of posthepatectomy-liver-failure is crucial, there is need of dynamic assessment of liver function, even intraoperatively…”
Get full text

Comparisons of In Vivo and In Vitro Opioid Effects of Newly Synthesized 14-Methoxycodeine-6- O -sulfate and Codeine-6- O -sulfate by Zádor, Ferenc, Mohammadzadeh, Amir, Balogh, Mihály, Zádori, Zoltán S, Király, Kornél, Barsi, Szilvia, Galambos, Anna Rita, László, Szilvia B, Hutka, Barbara, Váradi, András, Hosztafi, Sándor, Riba, Pál, Benyhe, Sándor, Fürst, Susanna, Al-Khrasani, Mahmoud

“…The present work represents the in vitro (potency, affinity, efficacy) and in vivo (antinociception, constipation) opioid pharmacology of the novel compound…”
Get full text

Pregabalin–Tolperisone Combination to Treat Neuropathic Pain: Improved Analgesia and Reduced Side Effects in Rats by Essmat, Nariman, Galambos, Anna Rita, Lakatos, Péter P, Karádi, Dávid Árpád, Mohammadzadeh, Amir, Abbood, Sarah Kadhim, Geda, Orsolya, Laufer, Rudolf, Király, Kornél, Riba, Pál, Zádori, Zoltán S, Szökő, Éva, Tábi, Tamás, Al-Khrasani, Mahmoud

“…The current treatment of neuropathic pain (NP) is unsatisfactory; therefore, effective novel agents or combination-based analgesic therapies are needed…”
Get full text

A dual role of lysophosphatidic acid type 2 receptor (LPAR2) in nonsteroidal anti-inflammatory drug-induced mouse enteropathy by Hutka, Barbara, Várallyay, Anett, László, Szilvia B., Tóth, András S., Scheich, Bálint, Paku, Sándor, Vörös, Imre, Pós, Zoltán, Varga, Zoltán V., Norman, Derek D., Balogh, Andrea, Benyó, Zoltán, Tigyi, Gábor, Gyires, Klára, Zádori, Zoltán S.

“…Lysophosphatidic acid (LPA) is a bioactive phospholipid mediator that has been found to ameliorate nonsteroidal anti-inflammatory drug (NSAID)-induced gastric…”
Get full text

The Nonsteroidal Anti-Inflammatory Drug Ketorolac Alters the Small Intestinal Microbiota and Bile Acids Without Inducing Intestinal Damage or Delaying Peristalsis in the Rat by Hutka, Barbara, Lázár, Bernadette, Tóth, András S., Ágg, Bence, László, Szilvia B., Makra, Nóra, Ligeti, Balázs, Scheich, Bálint, Király, Kornél, Al-Khrasani, Mahmoud, Szabó, Dóra, Ferdinandy, Péter, Gyires, Klára, Zádori, Zoltán S.

“…Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) induce significant damage to the small intestine, which is accompanied by changes in intestinal…”
Get full text

Chronic treatment with rofecoxib but not ischemic preconditioning of the myocardium ameliorates early intestinal damage following cardiac ischemia/reperfusion injury in rats by László, Szilvia B., Lázár, Bernadette, Brenner, Gábor B., Makkos, András, Balogh, Mihály, Al-Khrasani, Mahmoud, Hutka, Barbara, Mohammadzadeh, Amir, Kemény, Ágnes, László, Terézia, Scheich, Bálint, Szabados, Tamara, Kenyeres, Éva, Giricz, Zoltán, Bencsik, Péter, Varga, Zoltán V., Novák, Julianna, Helyes, Zsuzsanna, Ferdinandy, Péter, Gyires, Klára, Zádori, Zoltán S.

“…[Display omitted] There is some recent evidence that cardiac ischemia/reperfusion (I/R) injury induces intestinal damage within days, which contributes to…”
Get full text

Efficacy-Based Perspective to Overcome Reduced Opioid Analgesia of Advanced Painful Diabetic Neuropathy in Rats by Balogh, Mihály, Zádor, Ferenc, Zádori, Zoltán S, Shaqura, Mohammed, Király, Kornél, Mohammadzadeh, Amir, Varga, Bence, Lázár, Bernadette, Mousa, Shaaban A, Hosztafi, Sándor, Riba, Pál, Benyhe, Sándor, Gyires, Klára, Schäfer, Michael, Fürst, Susanna, Al-Khrasani, Mahmoud

“…Reduction of the opioid analgesia in diabetic neuropathic pain (DNP) results from μ-opioid receptor (MOR) reserve reduction. Herein, we examined the…”
Get full text

The Peripheral Versus Central Antinociception of a Novel Opioid Agonist: Acute Inflammatory Pain in Rats by Balogh, Mihály, Zádori, Zoltán S., Lázár, Bernadette, Karádi, Dávid, László, Szilvia, Mousa, Shaaban A., Hosztafi, Sándor, Zádor, Ferenc, Riba, Pál, Schäfer, Michael, Fürst, Susanna, Al-Khrasani, Mahmoud

“…Opioid analgesics devoid of central side effects are unmet medical need in the treatment of acute pain (e.g. post-operative pain). Recently, we have reported…”
Get full text

Brain neuropeptides in gastric mucosal protection by Gyires, Klára, Zádori, Zoltán S

“…Highlights • Neuropeptides given centrally are potent gastroprotective agents. • Their gastroprotective dose ranges differ significantly. • Additional…”
Get full text

Evidence for the gastric cytoprotective effect of centrally injected agmatine by Zádori, Zoltán S, Tóth, Viktória E, Fehér, Ágnes, Philipp, Kirsch, Németh, József, Gyires, Klára

“…Highlights • Central injection of agmatine induces gastric cytoprotection. • The protective effect depends on the integrity of the vagal nerve. • The effect is…”
Get full text

14-O-Methylmorphine: A Novel Selective Mu-Opioid Receptor Agonist with High Efficacy and Affinity by Zádor, Ferenc, Balogh, Mihály, Váradi, András, Zádori, Zoltán S., Király, Kornél, Szűcs, Edina, Varga, Bence, Lázár, Bernadette, Hosztafi, Sándor, Riba, Pál, Benyhe, Sándor, Fürst, Susanna, Al-Khrasani, Mahmoud

“…14-O-methyl (14-O-Me) group in morphine-6-O-sulfate (M6SU) or oxymorphone has been reported to be essential for enhanced affinity, potency and antinociceptive…”
Get full text