Search Results - "Yuzefpolskiy, Yevgeniy"

Early CD8 T-cell memory precursors and terminal effectors exhibit equipotent in vivo degranulation by Yuzefpolskiy, Yevgeniy, Baumann, Florian M., Kalia, Vandana, Sarkar, Surojit

“…Early after priming, effector CD8 T cells are distinguished into memory precursor and short-lived effector cell subsets （MPECs and SLECs）. Here, we delineated…”
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Dicer Regulates the Balance of Short-Lived Effector and Long-Lived Memory CD8 T Cell Lineages by Baumann, Florian M, Yuzefpolskiy, Yevgeniy, Sarkar, Surojit, Kalia, Vandana

“…MicroRNAs constitute a major post-transcriptional mechanism for controlling protein expression, and are emerging as key regulators during T cell development…”
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Development of a novel Francisella tularensis Live Vaccine Strain expressing ovalbumin provides insight into antigen-specific CD8+ T cell responses by Place, David E, Williamson, David R, Yuzefpolskiy, Yevgeniy, Katkere, Bhuvana, Sarkar, Surojit, Kalia, Vandana, Kirimanjeswara, Girish S

“…Progress towards a safe and effective vaccine for the prevention of tularemia has been hindered by a lack of knowledge regarding the correlates of protective…”
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Diminished responses to mRNA-based SARS-CoV-2 vaccines in individuals with rheumatoid arthritis on immune modifying therapies by Klebanoff, Samuel D, Rodda, Lauren B, Morishima, Chihiro, Wener, Mark H, Yuzefpolskiy, Yevgeniy, Bettelli, Estelle, Buckner, Jane H, Speake, Cate, Pepper, Marion, Campbell, Daniel J

“…Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disorder that causes debilitating swelling and destruction of the joints. People with RA are…”
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Identifying the role of antigen-specific resident memory CD4 T cells in maintaining disease during Experimental Autoimmune Encephalomyelitis a murine model of Multiple Sclerosis by Yuzefpolskiy, Yevgeniy, Oukka, Mohamed, Bettelli, Estelle

“…Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) driven by antigen-specific CD4+ T cell mediated destruction of the myelin…”
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Tracking the in vivo history and fate of IL-2 producing CD8 T cells during memory differentiation by Yuzefpolskiy, Yevgeniy, Sarkar, Surojit, Kalia, Vandana

“…IL-2 is a key driver of T cell responses critical for the conversion of resting antigen specific T cells into glycolytic powerhouses that undergo massive…”
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Querying resources in the tumor microenvironment using bystander memory T cells by Sarkar, Surojit, Sullivan, Peter, Yuzefpolskiy, Yevgeniy, Kalia, Vandana

“…The general paradigm is that the tumor microenvironment is non-conducive to sustaining productive cytotoxic T cell responses due to suppressive and…”
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Metabolic regulation by PD-1 signaling promotes long-lived quiescent CD8 T cell memory in mice by Kalia, Vandana, Yuzefpolskiy, Yevgeniy, Vegaraju, Adithya, Xiao, Hanxi, Baumann, Florian, Jatav, Shashank, Church, Candice, Prlic, Martin, Jha, Abhishek, Nghiem, Paul, Riddell, Stanley, Sarkar, Surojit

“…Inhibitory signaling in dysfunctional CD8 T cells through the programmed cell death 1 (PD-1) axis is well established in chronic viral infections and cancers…”
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Quiescence of Memory CD8+ T Cells Is Mediated by Regulatory T Cells through Inhibitory Receptor CTLA-4 by Kalia, Vandana, Penny, Laura Anne, Yuzefpolskiy, Yevgeniy, Baumann, Florian Martin, Sarkar, Surojit

“…Immune memory cells are poised to rapidly expand and elaborate effector functions upon reinfection yet exist in a functionally quiescent state. The paradigm is…”
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Autocrine and paracrine IL-2 signals collaborate to regulate distinct phases of CD8 T cell memory by Toumi, Ryma, Yuzefpolskiy, Yevgeniy, Vegaraju, Adithya, Xiao, Hanxi, Smith, Kendall A., Sarkar, Surojit, Kalia, Vandana

“…Differential interleukin-2 (IL-2) signaling and production are associated with disparate effector and memory fates. Whether the IL-2 signals perceived by CD8…”
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IL-2 Signals Program the Fate of Exhausted CD8 T cells by Kalia, Vandana, Xiao, Hanxi, Yuzefpolskiy, Yevgeniy, Sarkar, Surojit

“…The high affinity IL-2 receptor (IL-2Ra, CD25) is a key activation marker, which is transiently and heterogeneously expressed during the priming . While IL-2…”
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MicroRNA-17∼92 regulates effector and memory CD8 T-cell fates by modulating proliferation in response to infections by Khan, Arif A., Penny, Laura A., Yuzefpolskiy, Yevgeniy, Sarkar, Surojit, Kalia, Vandana

“…The precise microRNAs and their target cellular processes involved in generation of durable T-cell immunity remain undefined. Here we show a dynamic regulation…”
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Autocrine and paracrine IL-2 signals collaborate to regulate distinct phases of CD8 T cell memory by Kalia, Vandana, Yuzefpolskiy, Yevgeniy, Vegaraju, Adithya, Smith, Kendall A, Sarkar, Surojit

“…Differential IL-2 signaling is implicated in memory CD8 T cell fates. Autocrine IL-2 production is a hallmark of polyfunctional, long-lived lymphoid memory…”
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Programming of CD8 T Cell Quantity and Polyfunctionality by Direct IL-1 Signals by Sarkar, Surojit, Yuzefpolskiy, Yevgeniy, Xiao, Hanxi, Baumann, Florian M, Yim, Soojin, Lee, David J, Schenten, Dominik, Kalia, Vandana

“…IL-1, generally considered an amplifier of adaptive immune responses, has been proposed for use as adjuvant during immunization with weak immunogens. However,…”
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Cutting Edge: Effect of Disease-Modifying Therapies on SARS-CoV-2 Vaccine-Induced Immune Responses in Multiple Sclerosis Patients by Yuzefpolskiy, Yevgeniy, Morawski, Peter, Fahning, Mitch, Speake, Cate, Lord, Sandra, Chaudhary, Anu, Morishima, Chihiro, Wener, Mark H, Kita, Mariko, McCarthy, Lucas, Buckner, Jane H, Campbell, Daniel J, Bettelli, Estelle

“…Multiple sclerosis (MS) is a demyelinating inflammatory disease of the CNS treated by diverse disease-modifying therapies that suppress the immune system…”
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A novel preclinical immunocompetent CAR T cell mouse model for solid tumors by Sullivan, Peter M, Arguedas-Jimenez, Laura, Johnson, Adam, Yokoyama, Jason, Yuzefpolskiy, Yevgeniy, Jensen, Michael, Kalia, Vandana, Sarkar, Surojit

“…Chimeric antigen receptor (CAR) T cells therapies have made substantial progress in treating blood cancers in humans. However, CAR T therapies currently have…”
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Autocrine IL-2 programs survival of exhausted CD8 T cells during chronic infection by Yuzefpolskiy, Yevgeniy, Barman, Soumik, Smith, Kendall A, Sarkar, Surojit, Kalia, Vandana

“…Loss of T cell function is a hallmark of chronic infections (such as HIV, HCV) and cancers. Chronic antigenic stimulation leads to a progressive, hierarchical…”
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PD-1 signals instruct a critical metabolic switch for maintenance of T cell memory by Yuzefpolskiy, Yevgeniy, Baumann, Florian M, Penny, Laura A, Kalia, Vandana, Sarkar, Surojit

“…PD-1 is highly expressed on CD8 T cells during activation, both in acute and chronic viral infections. Inhibitory signaling in cytotoxic T cells through the…”
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The Role of Early Autocrine IL-2 Signals in Programming Antigen-Specific CD8 T Cell Responses by Yuzefpolskiy, Yevgeniy

“…IL-2 is a potent cytokine in mediating antigen-specific CD8 T cell responses. Following antigen priming, IL-2 signals drive the differentiation of resting…”
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Development of a novel Francisella tularensis Live Vaccine Strain expressing ovalbumin provides insight into antigen-specific CD8.sup.+ T cell responses by Place, David E, Williamson, David R, Yuzefpolskiy, Yevgeniy, Katkere, Bhuvana, Sarkar, Surojit, Kalia, Vandana, Kirimanjeswara, Girish S

“…Progress towards a safe and effective vaccine for the prevention of tularemia has been hindered by a lack of knowledge regarding the correlates of protective…”
Get full text