Search Results - "Yuval Blat"

Drug Discovery of Therapies for Duchenne Muscular Dystrophy by Blat, Yuval, Blat, Shachar

“…Duchenne muscular dystrophy (DMD) is a genetic, lethal, muscle disorder caused by the loss of the muscle protein, dystrophin, leading to progressive loss of…”
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Physical and Functional Interactions among Basic Chromosome Organizational Features Govern Early Steps of Meiotic Chiasma Formation by Blat, Yuval, Protacio, Reine U., Hunter, Neil, Kleckner, Nancy

“…Analysis of meiotic recombination by functional genomic approaches reveals prominent spatial and functional interactions among diverse organizational…”
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The SUMO-1 Isopeptidase Smt4 Is Linked to Centromeric Cohesion through SUMO-1 Modification of DNA Topoisomerase II by Bachant, Jeff, Alcasabas, Annette, Blat, Yuval, Kleckner, Nancy, Elledge, Stephen J

“…In S. cerevisiae, posttranslational modification by the ubiquitin-like Smt3/SUMO-1 protein is essential for survival, but functions and cellular targets for…”
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A renaissance for the contact system in blood coagulation? by Blat, Yuval, Seiffert, Dietmar

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Feedback activation of factor XI by thrombin does not occur in plasma by Pedicord, Donna L, Seiffert, Dietmar, Blat, Yuval

“…In this study, we tested the hypothesis that factor XI (FXI) activation occurs in plasma following activation of the extrinsic pathway by thrombin-mediated…”
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An electrophoretic mobility shift assay for the identification and kinetic analysis of acetyl transferase inhibitors by Fanslau, Caroline, Pedicord, Donna, Nagulapalli, Sujatha, Gray, Hillary, Pang, Suhong, Jayaraman, Lata, Lippy, Jonathan, Blat, Yuval

“…Histone acetyl transferases are important regulators of cellular homeostasis. This study describes a sensitive acetyl transferase electrophoretic mobility…”
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Non-Competitive Inhibition by Active Site Binders by Blat, Yuval

“…Classical enzymology has been used for generations to understand the interactions of inhibitors with their enzyme targets. Enzymology tools enabled prediction…”
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Phosphorylation-dependent binding of the chemotaxis signal molecule CheY to its phosphatase, CheZ by Blat, Yuval, Eisenbach, Michael

“…Bacterial chemotaxis is accomplished by regulating the direction of flagellar rotation. The primary target of the control appears to be CheY, a diffusible…”
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A general liquid chromatography/mass spectroscopy-based assay for detection and quantitation of methyltransferase activity by Salyan, Mary Ellen K., Pedicord, Donna L., Bergeron, Laurie, Mintier, Gabe A., Hunihan, Lisa, Kuit, Kathy, Balanda, Lynn A., Robertson, Barbara J., Feder, John N., Westphal, Ryan, Shipkova, Petia A., Blat, Yuval

“…Methyltransferases form a large class of enzymes, most of which use S-adenosylmethionine as the methyl donor. In fact, S-adenosylmethionine is second only to…”
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Tyrosine Kinase 2-mediated Signal Transduction in T Lymphocytes Is Blocked by Pharmacological Stabilization of Its Pseudokinase Domain by Tokarski, John S., Zupa-Fernandez, Adriana, Tredup, Jeffrey A., Pike, Kristen, Chang, ChiehYing, Xie, Dianlin, Cheng, Lihong, Pedicord, Donna, Muckelbauer, Jodi, Johnson, Stephen R., Wu, Sophie, Edavettal, Suzanne C., Hong, Yang, Witmer, Mark R., Elkin, Lisa L., Blat, Yuval, Pitts, William J., Weinstein, David S., Burke, James R.

“…Inhibition of signal transduction downstream of the IL-23 receptor represents an intriguing approach to the treatment of autoimmunity. Using a chemogenomics…”
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Cohesins Bind to Preferential Sites along Yeast Chromosome III, with Differential Regulation along Arms versus the Centric Region by Blat, Yuval, Kleckner, Nancy

“…Sister chromatid cohesion is mediated by evolutionary conserved chromosomal proteins, termed “cohesins.” Using an extension of chromatin immunoprecipitation,…”
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Postsynaptic diacylglycerol lipase α mediates retrograde endocannabinoid suppression of inhibition in mouse prefrontal cortex by Yoshino, Hiroki, Miyamae, Takeaki, Hansen, Gwenn, Zambrowicz, Brian, Flynn, Michael, Pedicord, Donna, Blat, Yuval, Westphal, Ryan S., Zaczek, Robert, Lewis, David A., Gonzalez‐Burgos, Guillermo

“…Non‐Technical Summary  In multiple brain regions, endogenous cannabinoids suppress inhibitory synaptic transmission; however, the biochemical/molecular…”
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Mutants with Defective Phosphatase Activity Show No Phosphorylation-dependent Oligomerization of CheZ by Blat, Yuval, Eisenbach, Michael

“…CheZ is the phosphatase of CheY, the response regulator in bacterial chemotaxis. The mechanism by which the activity of CheZ is regulated is not known. We used…”
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Oligomerization of the Phosphatase CheZ Upon Interaction with the Phosphorylated Form of CheY by Blat, Yuval, Eisenbach, Michael

“…Earlier studies have suggested that CheZ, the phosphatase of the signaling protein CheY in bacterial chemotaxis, may be in an oligomeric state both when bound…”
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Abstract 1140: A novel MTA non-competitive PRMT5 inhibitor by Malik, Rohit, Park, Peter K., Barbieri, Christopher M., Blat, Yuval, Sheriff, Steven, Weigelt, Carolyn A., Kopcho, Lisa M., Celiktas, Muge, Ruzanov, Max, Naglich, Joseph G., Price, Jennifer L., Harner, Mary, Omalley, Kevin M., Deng, JIngjing, Schmitz, William, Li, Guo, Ruan, Zheming, Qin, Lan-ying, Duke, Gerald J., Rodrigo, Iyoncy, Witmer, Mark R., Harden, David G., Demes, Shilpa, Arey, Brian J., Soars, Matt, Fink, Brian E., Gavai, Ashvinikumar V., Vite, Gregory D., Voliva, Charles F.

“…Abstract The chromosome 9p21 (chr9p21) locus is deleted in almost 10% of all cancer types. This locus includes the CDKN2A gene that encodes the critical tumor…”
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Identification and optimization of a novel series of indoleamine 2,3-dioxygenase inhibitors by Markwalder, Jay A., Seitz, Steven P., Blat, Yuval, Elkin, Lisa, Hunt, John T., Pabalan, Jonathan G., Jure-Kunkel, Maria N., Vite, Gregory D., Covello, Kelly

“…[Display omitted] The discovery of a series of structurally-novel biaryl urea IDO inhibitors is described. Optimization of a micromolar hit through iterative…”
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Building homogeneous time-resolved fluorescence resonance energy transfer assays for characterization of bivalent inhibitors of an inhibitor of apoptosis protein target by Chaudhry, Charu, Davis, Jonathan, Zhang, Yong, Posy, Shana, Lei, Ming, Shen, Henry, Yan, Chunhong, Devaux, Brigitte, Zhang, Litao, Blat, Yuval, Metzler, William, Borzilleri, Robert M., Talbott, Randy L.

“…XIAP (X-chromosome-linked inhibitor of apoptosis protein) is a central apoptosis regulator that blocks cell death by inhibiting caspase-3, caspase-7, and…”
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Structure activity relationship studies on chemically non-reactive glycine sulfonamide inhibitors of diacylglycerol lipase by Chupak, Louis S., Zheng, Xiaofan, Hu, Shuanghua, Huang, Yazhong, Ding, Min, Lewis, Martin A., Westphal, Ryan S., Blat, Yuval, McClure, Andrea, Gentles, Robert G.

“…[Display omitted] N-Benzylic-substituted glycine sulfonamides that reversibly inhibit diacylglycerol (DAG) lipases are reported. Detailed herein are the…”
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Discovery of a Highly Selective JAK2 Inhibitor, BMS-911543, for the Treatment of Myeloproliferative Neoplasms by Wan, Honghe, Schroeder, Gretchen M, Hart, Amy C, Inghrim, Jennifer, Grebinski, James, Tokarski, John S, Lorenzi, Matthew V, You, Dan, Mcdevitt, Theresa, Penhallow, Becky, Vuppugalla, Ragini, Zhang, Yueping, Gu, Xiaomei, Iyer, Ramaswamy, Lombardo, Louis J, Trainor, George L, Ruepp, Stefan, Lippy, Jonathan, Blat, Yuval, Sack, John S, Khan, Javed A, Stefanski, Kevin, Sleczka, Bogdan, Mathur, Arvind, Sun, Jung-Hui, Wong, Michael K, Wu, Dauh-Rurng, Li, Peng, Gupta, Anuradha, Arunachalam, P. N, Pragalathan, Bala, Narayanan, Sankara, K.C, Nanjundaswamy, Kuppusamy, Prakasam, Purandare, Ashok V

“…JAK2 kinase inhibitors are a promising new class of agents for the treatment of myeloproliferative neoplasms and have potential for the treatment of other…”
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Molecular characterization and identification of surrogate substrates for diacylglycerol lipase α by Pedicord, Donna L., Flynn, Michael J., Fanslau, Caroline, Miranda, Maricar, Hunihan, Lisa, Robertson, Barbara J., Pearce, Bradley C., Yu, Xuan-Chuan, Westphal, Ryan S., Blat, Yuval

“…► Identified the catalytic triad of DAGLα. ► Demonstrated that DAGLα C-terminal domain is not needed for catalysis. ► Identified chromogenic and fluorogenic…”
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