Search Results - "Yutaka HATTORI"

A thermoresponsive cationic block copolymer brush-grafted silica bead interface for temperature-modulated separation of adipose-derived stem cells by Nagase, Kenichi, Okada, Akari, Matsuda, Junnosuke, Ichikawa, Daiju, Hattori, Yutaka, Kanazawa, Hideko

“…Adipose-derived mesenchymal stem cells (ADSCs) have beneficial effects in cell transplantation therapy; these cells are collected from adipose tissue using…”
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Integrin β5 and β7 expression in lenalidomide-resistant multiple myeloma cells by Hattori, Yutaka, Futo, Takumi, Uozaki, Ryo, Ichikawa, Daiju, Yamaguchi, Takashi, Yamamoto, Tomofumi, Matsushita, Maiko, Hirao, Maki

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Antibody drug separation using thermoresponsive anionic polymer brush modified beads with optimised electrostatic and hydrophobic interactions by Nagase, Kenichi, Ishii, Saki, Ikeda, Koji, Yamada, Sota, Ichikawa, Daiju, Akimoto, Aya Mizutani, Hattori, Yutaka, Kanazawa, Hideko

“…Antibody drugs play an important role in biopharmaceuticals, because of the specificity for target biomolecules and reduction of side effects. Thus, separation…”
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Temperature-modulated cell-separation column using temperature-responsive cationic copolymer hydrogel-modified silica beads by Nagase, Kenichi, Inanaga, Daimu, Ichikawa, Daiju, Mizutani Akimoto, Aya, Hattori, Yutaka, Kanazawa, Hideko

“…[Display omitted] •A thermoresponsive-cationic beads packed column was developed.•Retention and elution of cells was modulated by changing temperature.•Cell…”
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Dietary Supplementation with Sodium Butyrate Reduces High-sucrose Diet-induced Hepatic Accumulation of Triacylglycerols and Expression of Fatty Acid Synthesis Enzymes in Rats by Hattori, Yutaka, Tsutsui, Sayo, Yamada, Chihiro, Kobayashi, Yota, Nakagawa, Tomoyuki, Shimada, Masaya

“…We investigated the effects of dietary supplementation with sodium butyrate (NaB) on the lipid levels, gene expression, and proteins related to lipid…”
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Immunomodulatory Effect of Proteasome Inhibitors via the Induction of Immunogenic Cell Death in Myeloma Cells by Matsushita, Maiko, Kashiwazaki, Sho, Kamiko, Satoshi, Kobori, Michio, Osada, Makoto, Kunieda, Hisako, Hirao, Maki, Ichikawa, Daiju, Hattori, Yutaka

“…Several anti-cancer drugs are known to have immunomodulatory effects, including immunogenic cell death (ICD) of cancer cells. ICD is a form of apoptosis which…”
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SORT1/LAMP2-mediated extracellular vesicle secretion and cell adhesion are linked to lenalidomide resistance in multiple myeloma by Yamamoto, Tomofumi, Nakayama, Jun, Yamamoto, Yusuke, Kuroda, Masahiko, Hattori, Yutaka, Ochiya, Takahiro

“…Multiple myeloma (MM) is a hematopoietic malignancy whose prognosis has improved with the development of new agents such as lenalidomide over the last decade…”
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Negative E-cadherin expression on bone marrow myeloma cell membranes is associated with extramedullary disease [version 1; peer review: 2 approved] by Hirao, Maki, Yamazaki, Kohei, Watanabe, Kentaro, Mukai, Kiyoshi, Hirose, Shigemichi, Osada, Makoto, Tsukada, Yuiko, Kunieda, Hisako, Denda, Ryunosuke, Kikuchi, Takahide, Sugimori, Hiroki, Okamoto, Shinichiro, Hattori, Yutaka

“…Background: The loss of E-cadherin expression and the induction of N-cadherin are known as hallmarks of the epithelial-to-mesenchymal transition, an essential…”
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A novel derivative (GTN024) from a natural product, komaroviquinone, induced the apoptosis of high-risk myeloma cells via reactive oxygen production and ER stress by Okayama, Mikio, Kitabatake, Shotaro, Sato, Mariko, Fujimori, Kota, Ichikawa, Daiju, Matsushita, Maiko, Suto, Yutaka, Iwasaki, Genji, Yamada, Taketo, Kiuchi, Fumiyuki, Hirao, Maki, Kunieda, Hisako, Osada, Makoto, Okamoto, Shinichiro, Hattori, Yutaka

“…New drugs have significantly improved the survival of patients with multiple myeloma (MM), but the prognosis of MM patients with high-risk cytogenetic changes…”
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Characteristics of a Novel Target Antigen against Myeloma Cells for Immunotherapy by Matsushita, Maiko, Saito, Saku, Yokoe, Shinya, Ichikawa, Daiju, Hattori, Yutaka

“…Despite the availability of therapeutic treatments, multiple myeloma is an incurable haematological disorder. In this study, we aimed to clarify the role of…”
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GTN057, a komaroviquinone derivative, induced myeloma cells' death in vivo and inhibited c‐MET tyrosine kinase by Okayama, Mikio, Fujimori, Kota, Sato, Mariko, Samata, Koichi, Kurita, Koki, Sugiyama, Hiromu, Suto, Yutaka, Iwasaki, Genji, Yamada, Taketo, Kiuchi, Fumiyuki, Ichikawa, Daiju, Matsushita, Maiko, Hirao, Maki, Kunieda, Hisako, Yamazaki, Kohei, Hattori, Yutaka

“…Objective Despite the development of newly developed drugs, most multiple myeloma (MM) patients with high‐risk cytogenetic abnormalities such as t(4;14) or…”
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Synthesis and biological evaluation of the natural product komaroviquinone and related compounds aiming at a potential therapeutic lead compound for high-risk multiple myeloma by Suto, Yutaka, Sato, Mariko, Fujimori, Kota, Kitabatake, Shotaro, Okayama, Mikio, Ichikawa, Daiju, Matsushita, Maiko, Yamagiwa, Noriyuki, Iwasaki, Genji, Kiuchi, Fumiyuki, Hattori, Yutaka

“…[Display omitted] Alternatives of treatments for multiple myeloma (MM) have become increasingly available with the advent of new drugs such as proteasome…”
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Identification of Novel HLA-A24:02-Restricted Epitope Derived from a Homeobox Protein Expressed in Hematological Malignancies by Matsushita, Maiko, Otsuka, Yohei, Tsutsumida, Naoya, Tanaka, Chiaki, Uchiumi, Akane, Ozawa, Koji, Suzuki, Takuma, Ichikawa, Daiju, Aburatani, Hiroyuki, Okamoto, Shinichiro, Kawakami, Yutaka, Hattori, Yutaka

“…The homeobox protein, PEPP2 (RHOXF2), has been suggested as a cancer/testis (CT) antigen based on its expression pattern. However, the peptide epitope of PEPP2…”
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Negative E-cadherin expression on bone marrow myeloma cell membranes is associated with extramedullary disease [version 2; peer review: 2 approved] by Hirao, Maki, Yamazaki, Kohei, Watanabe, Kentaro, Mukai, Kiyoshi, Hirose, Shigemichi, Osada, Makoto, Tsukada, Yuiko, Kunieda, Hisako, Denda, Ryunosuke, Kikuchi, Takahide, Sugimori, Hiroki, Okamoto, Shinichiro, Hattori, Yutaka

“…Background: The loss of E-cadherin expression and the induction of N-cadherin are known as hallmarks of the epithelial-to-mesenchymal transition, an essential…”
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Dietary Supplementation with Sodium Butyrate Reduces High-sucrose Diet-induced Hepatic Accumulation of Triacylglycerols and Expression of Fatty Acid Synthesis Enzymes in Rats by Yutaka Hattori, Sayo Tsutsui, Chihiro Yamada, Yota Kobayashi, Tomoyuki Nakagawa, Masaya Shimada

“…[Abstract] : We investigated the effects of dietary supplementation with sodium butyrate (NaB) on the lipid levels, gene expression, and proteins related to…”
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A novel phthalimide derivative, TC11, has preclinical effects on high-risk myeloma cells and osteoclasts by Matsushita, Maiko, Ozaki, Yoshie, Hasegawa, Yuka, Terada, Fukiko, Tabata, Noriko, Shiheido, Hirokazu, Yanagawa, Hiroshi, Oikawa, Tsukasa, Matsuo, Koichi, Du, Wenlin, Yamada, Taketo, Hozumi, Masashi, Ichikawa, Daiju, Hattori, Yutaka

“…Despite the recent advances in the treatment of multiple myeloma (MM), MM patients with high-risk cytogenetic changes such as t(4;14) translocation or deletion…”
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A phthalimide derivative that inhibits centrosomal clustering is effective on multiple myeloma by Shiheido, Hirokazu, Terada, Fukiko, Tabata, Noriko, Hayakawa, Ichigo, Matsumura, Nobutaka, Takashima, Hideaki, Ogawa, Yoko, Du, Wenlin, Yamada, Taketo, Shoji, Mitsuru, Sugai, Takeshi, Doi, Nobuhide, Iijima, Shiro, Hattori, Yutaka, Yanagawa, Hiroshi

“…Despite the introduction of newly developed drugs such as lenalidomide and bortezomib, patients with multiple myeloma are still difficult to treat and have a…”
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An anilinoquinazoline derivative inhibits tumor growth through interaction with hCAP-G2, a subunit of condensin II by Shiheido, Hirokazu, Naito, Yuhei, Kimura, Hironobu, Genma, Hiroaki, Takashima, Hideaki, Tokunaga, Mayuko, Ono, Takao, Hirano, Tatsuya, Du, Wenlin, Yamada, Taketo, Doi, Nobuhide, Iijima, Shiro, Hattori, Yutaka, Yanagawa, Hiroshi

“…We screened 46 novel anilinoquinazoline derivatives for activity to inhibit proliferation of a panel of human cancer cell lines. Among them, Q15 showed potent…”
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Single‐institute phase 2 study of thalidomide treatment for refractory or relapsed multiple myeloma: Prognostic factors and unique toxicity profile by Hattori, Yutaka, Okamoto, Shin‐ichiro, Shimada, Naoki, Kakimoto, Tsunayuki, Morita, Kunihiko, Tanigawara, Yusuke, Ikeda, Yasuo

“…We previously reported a pilot study of thalidomide monotherapy for Japanese patients with refractory or relapsed multiple myeloma. In the present work, we…”
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NK4, an antagonist of hepatocyte growth factor (HGF), inhibits growth of multiple myeloma cells: molecular targeting of angiogenic growth factor by Du, Wenlin, Hattori, Yutaka, Yamada, Taketo, Matsumoto, Kunio, Nakamura, Toshikazu, Sagawa, Morihiko, Otsuki, Takemi, Niikura, Takako, Nukiwa, Toshihiro, Ikeda, Yasuo

“…Hepatocyte growth factor (HGF) promotes cell growth and motility and also increases neovascularization. Multiple myeloma (MM) cells produce HGF, and the plasma…”
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