Evidences of in vivo bioactivity of Fe-bioceramic composites for temporary bone implants

Evidences of in vivo bioactivity of Fe-bioceramic composites for temporary bone implants

Iron-bioceramic composites have been developed as biodegradable implant materials with tailored degradation behavior and bioactive features. In the current work, in vivo bioactivity of the composites was comprehensively studied by using sheep animal model. Five groups of specimens (Fe-HA, Fe-TCP, Fe...

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Published in:Journal of biomedical materials research. Part B, Applied biomaterials Vol. 103; no. 7; pp. 1354 - 1365
Main Authors: Ulum, Mokhamad F., Nasution, Ahmad K., Yusop, Abdul H., Arafat, Andril, Kadir, Mohammed Rafiq A., Juniantito, Vetnizah, Noviana, Deni, Hermawan, Hendra
Format: Journal Article
Language:English
Published: United States Blackwell Publishing Ltd 01-10-2015
Wiley Subscription Services, Inc
Subjects:
Animals
bioactive
bioceramics
biodegradable metals
Biomedical materials
Bone Substitutes - chemistry
Bone Substitutes - pharmacokinetics
Bone Substitutes - pharmacology
Ceramics - chemistry
Ceramics - pharmacokinetics
Ceramics - pharmacology
composites
in vivo
Iron - chemistry
Iron - pharmacokinetics
Iron - pharmacology
Male
Materials research
Materials science
Materials Testing
Sheep
biodegradable metals
composites
bioceramics
in vivo
bioactive
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Summary:Iron-bioceramic composites have been developed as biodegradable implant materials with tailored degradation behavior and bioactive features. In the current work, in vivo bioactivity of the composites was comprehensively studied by using sheep animal model. Five groups of specimens (Fe-HA, Fe-TCP, Fe-BCP composites, and pure-Fe and SS316L as controls) were surgically implanted into medio proximal region of the radial bones. Real-time ultrasound analysis showed a decreased echo pattern at the peri-implant biodegradation site of the composites indicating minimal tissue response during the wound healing process. Peripheral whole blood biomarkers monitoring showed a normal dynamic change of blood cellular responses and no stress effect was observed. Meanwhile, the released Fe ion concentration was increasing along the implantation period. Histological analysis showed that the composites corresponded with a lower inflammatory giant cell count than that of SS316L. Analysis of the retrieved implants showed a thicker degradation layer on the composites compared with pure-Fe. It can be concluded that the iron-bioceramic composites are bioactive and induce a preferable wound healing process.
Bibliography:istex:06DC9F47B3D914EC509FC39800F68275BD6BF729
Indonesian Ministry of Education and Culture for the DGHE - No. 10/IT3.11/LT/2014
Laval University and CHU de Québec for the "Fonds de Démarrage"
Indonesian Ministry of Research and Technology for the Insentif Riset SINas - No. RT-2012-786
ark:/67375/WNG-56FLP8P5-0
Malaysian Ministry of Education and Universiti Teknologi Malaysia for the Tier-1 - No. Q.J130000.2545.05H55
ArticleID:JBMB33315
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1552-4973
1552-4981
DOI:10.1002/jbm.b.33315