Three dimensional optical imaging of blood volume and oxygenation in the neonatal brain

Three dimensional optical imaging of blood volume and oxygenation in the neonatal brain

Optical methods provide a means of monitoring cerebral oxygenation in newborn infants at risk of brain injury. A 32-channel optical imaging system has been developed with the aim of reconstructing three-dimensional images of regional blood volume and oxygenation. Full image data sets were acquired f...

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Bibliographic Details
Published in:NeuroImage (Orlando, Fla.) Vol. 31; no. 4; pp. 1426 - 1433
Main Authors: Austin, T., Gibson, A.P., Branco, G., Yusof, R.Md, Arridge, S.R., Meek, J.H., Wyatt, J.S., Delpy, D.T., Hebden, J.C.
Format: Journal Article
Language:English
Published: United States Elsevier Inc 15-07-2006
Elsevier Limited
Subjects:
Babies
Blood Volume - physiology
Brain Chemistry - physiology
Brain damage
Brain Diseases - congenital
Cerebral Hemorrhage - congenital
Cerebral Hemorrhage - pathology
Female
Humans
Image Processing, Computer-Assisted
Infant
Infant, Newborn - physiology
Infant, Premature
Light
Magnetic Resonance Imaging
Male
Medical imaging
Oxygen - blood
Reference Values
Tomography
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Summary:Optical methods provide a means of monitoring cerebral oxygenation in newborn infants at risk of brain injury. A 32-channel optical imaging system has been developed with the aim of reconstructing three-dimensional images of regional blood volume and oxygenation. Full image data sets were acquired from 14 out of 24 infants studied; successful images have been reconstructed in 8 of these infants. Regional variations in cerebral blood volume and tissue oxygen saturation are present in healthy preterm infants. In an infant with a large unilateral intraventricular haemorrhage, a corresponding region of low oxygen saturation was detected. These results suggest that optical tomography may provide an appropriate technique for investigating regional cerebral haemodynamics and oxygenation at the cotside.
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ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2006.02.038