Search Results - "Yury Tsybin"

Middle-Down Analysis of Monoclonal Antibodies with Electron Transfer Dissociation Orbitrap Fourier Transform Mass Spectrometry by Fornelli, Luca, Ayoub, Daniel, Aizikov, Konstantin, Beck, Alain, Tsybin, Yury O

“…The rapid growth of approved biotherapeutics, e.g., monoclonal antibodies or immunoglobulins G (IgGs), demands improved techniques for their quality control…”
Get full text

Top or Middle? Up or Down? Toward a Standard Lexicon for Protein Top-Down and Allied Mass Spectrometry Approaches by Lermyte, Frederik, Tsybin, Yury O., O’Connor, Peter B., Loo, Joseph A.

“…In recent years, there has been increasing interest in top-down mass spectrometry (TDMS) approaches for protein analysis, driven both by technological…”
Get full text

Best practices and benchmarks for intact protein analysis for top-down mass spectrometry by Donnelly, Daniel P., Rawlins, Catherine M., DeHart, Caroline J., Fornelli, Luca, Schachner, Luis F., Lin, Ziqing, Lippens, Jennifer L., Aluri, Krishna C., Sarin, Richa, Chen, Bifan, Lantz, Carter, Jung, Wonhyeuk, Johnson, Kendall R., Koller, Antonius, Wolff, Jeremy J., Campuzano, Iain D. G., Auclair, Jared R., Ivanov, Alexander R., Whitelegge, Julian P., Paša-Tolić, Ljiljana, Chamot-Rooke, Julia, Danis, Paul O., Smith, Lloyd M., Tsybin, Yury O., Loo, Joseph A., Ge, Ying, Kelleher, Neil L., Agar, Jeffrey N.

“…One gene can give rise to many functionally distinct proteoforms, each of which has a characteristic molecular mass. Top-down mass spectrometry enables the…”
Get full text

Proteoform: a single term describing protein complexity by Smith, Lloyd M, Kelleher, Neil L

Get full text

Fourier transform ion cyclotron resonance mass spectrometry at the true cyclotron frequency by Nagornov, Konstantin O., Tsybin, Oleg Y., Nicol, Edith, Kozhinov, Anton N., Tsybin, Yury O.

“…Ion cyclotron resonance (ICR) cells provide stability and coherence of ion oscillations in crossed electric and magnetic fields over extended periods of time…”
Get full text

The Human Proteoform Project: Defining the human proteome by Smith, Lloyd M, Agar, Jeffrey N, Chamot-Rooke, Julia, Danis, Paul O, Ge, Ying, Loo, Joseph A, Paša-Tolić, Ljiljana, Tsybin, Yury O, Kelleher, Neil L

“…Proteins are the primary effectors of function in biology, and thus, complete knowledge of their structure and properties is fundamental to deciphering…”
Get full text

Drosophila melanogaster cloak their eggs with pheromones, which prevents cannibalism by Narasimha, Sunitha, Nagornov, Konstantin O, Menin, Laure, Mucciolo, Antonio, Rohwedder, Astrid, Humbel, Bruno M, Stevens, Martin, Thum, Andreas S, Tsybin, Yury O, Vijendravarma, Roshan K

“…Oviparous animals across many taxa have evolved diverse strategies that deter egg predation, providing valuable tests of how natural selection mitigates direct…”
Get full text

Principles of electron capture and transfer dissociation mass spectrometry applied to peptide and protein structure analysis by Zhurov, Konstantin O, Fornelli, Luca, Wodrich, Matthew D, Laskay, Ünige A, Tsybin, Yury O

“…This tutorial review describes the principles and practices of electron capture and transfer dissociation (ECD/ETD or ExD) mass spectrometry (MS) employed for…”
Get more information

A five-level classification system for proteoform identifications by Smith, Lloyd M., Thomas, Paul M., Shortreed, Michael R., Schaffer, Leah V., Fellers, Ryan T., LeDuc, Richard D., Tucholski, Trisha, Ge, Ying, Agar, Jeffrey N., Anderson, Lissa C., Chamot-Rooke, Julia, Gault, Joseph, Loo, Joseph A., Paša-Tolić, Ljiljana, Robinson, Carol V., Schlüter, Hartmut, Tsybin, Yury O., Vilaseca, Marta, Vizcaíno, Juan Antonio, Danis, Paul O., Kelleher, Neil L.

“…To the editorThe term proteoform, introduced in Nature Methods in 2013 (ref. 1), has rapidly gained acceptance in the proteomics community. The challenge and…”
Get full text

Evaluation of atmospheric-plasma-source absorption mode Fourier transform Orbitrap mass spectrometry for chlorinated paraffin mixtures by Masucci, Claudia, Nagornov, Konstantin O., Kozhinov, Anton N., Kraft, Kevin, Tsybin, Yury O., Bleiner, Davide

“…Chlorinated paraffins (CP) are complex molecular mixtures occurring in a wide range of isomers and homologs of environmental hazards, whose analytical…”
Get full text

Intensity-Independent Noise Filtering in FT MS and FT MS/MS Spectra for Shotgun Lipidomics by Schuhmann, Kai, Thomas, Henrik, Ackerman, Jacobo Miranda, Nagornov, Konstantin O, Tsybin, Yury O, Shevchenko, Andrej

“…Shotgun lipidomics relies on the direct infusion of total lipid extracts into a high resolution tandem mass spectrometer. A single shotgun analysis produces…”
Get full text

Improved Uranium Isotope Ratio Analysis in Liquid Sampling–Atmospheric Pressure Glow Discharge/Orbitrap FTMS Coupling through the Use of an External Data Acquisition System by Bills, Jacob R, Nagornov, Konstantin O, Kozhinov, Anton N, Williams, Tyler J, Tsybin, Yury O, Marcus, R. Kenneth

“…Isotope ratio (IR) analysis of natural abundance uranium presents a formidable challenge for mass spectrometry (MS): the required spectral dynamic range needs…”
Get full text

Structural Analysis of Monoclonal Antibodies with Top-down and Middle-down Electron Transfer Dissociation Mass Spectrometry: The First Decade by Fornelli, Luca, Ayoub, Daniel, Srzentic, Kristina, Nagornov, Konstantin O, Kozhinov, Anton N, Gasilova, Natalia, Menin, Laure, Beck, Alain, Tsybin, Yury O

“…Monoclonal antibodies (mAbs) are protein biotherapeutics with a proven efficacy toward fighting life-threatening diseases. Their exceptional healing potential…”
Get full text

Drug-to-Antibody Ratio Estimation via Proteoform Peak Integration in the Analysis of Antibody–Oligonucleotide Conjugates with Orbitrap Fourier Transform Mass Spectrometry by Nagornov, Konstantin O, Gasilova, Natalia, Kozhinov, Anton N, Virta, Pasi, Holm, Patrik, Menin, Laure, Nesatyy, Victor J, Tsybin, Yury O

“…The therapeutic efficacy and pharmacokinetics of antibody–drug conjugates (ADCs) in general, and antibody–oligonucleotide conjugates (AOCs) in particular,…”
Get full text

Transient-Mediated Simulations of FTMS Isotopic Distributions and Mass Spectra to Guide Experiment Design and Data Analysis by Nagornov, Konstantin O, Kozhinov, Anton N, Gasilova, Natalia, Menin, Laure, Tsybin, Yury O

“…Fourier transform mass spectrometry (FTMS) applications require accurate analysis of extremely complex mixtures of species in wide mass and charge state…”
Get full text

Structural Analysis of Intact Monoclonal Antibodies by Electron Transfer Dissociation Mass Spectrometry by Tsybin, Yury O, Fornelli, Luca, Stoermer, Carsten, Luebeck, Markus, Parra, Julien, Nallet, Sophie, Wurm, Florian M, Hartmer, Ralf

“…Improving qualitative and quantitative characterization of monoclonal antibodies is essential, because of their increasing popularity as therapeutic drug…”
Get full text

Narrow Aperture Detection Electrodes ICR Cell with Quadrupolar Ion Detection for FT-ICR MS at the Cyclotron Frequency by Nagornov, Konstantin O, Kozhinov, Anton N, Nicol, Edith, Tsybin, Oleg Yu, Touboul, David, Brunelle, Alain, Tsybin, Yury O

“…Ion signal detection at the true (unperturbed) cyclotron frequency instead of the conventional reduced cyclotron frequency has remained a formidable challenge…”
Get full text

Evaluation of High-Field Orbitrap Fourier Transform Mass Spectrometer for Petroleomics by Zhurov, Konstantin O, Kozhinov, Anton N, Tsybin, Yury O

“…The performance of the high-field Orbitrap Fourier transform mass spectrometer (FTMS) is evaluated in the context of petroleum sample analysis. Pertinent…”
Get full text

Trace-Level Persistent Organic Pollutant Analysis with Gas-Chromatography Orbitrap Mass SpectrometryEnhanced Performance by Complementary Acquisition and Processing of Time-Domain Data by Nagornov, Konstantin O, Zennegg, Markus, Kozhinov, Anton N, Tsybin, Yury O, Bleiner, Davide

“…The range of commercial techniques for high-resolution gas-chromatography–mass spectrometry (GC–MS) has been recently extended with the introduction of GC…”
Get full text

Metal-Based Inhibition of Poly(ADP-ribose) Polymerase − The Guardian Angel of DNA by Mendes, Filipa, Groessl, Michael, Nazarov, Alexey A, Tsybin, Yury O, Sava, Gianni, Santos, Isabel, Dyson, Paul J, Casini, Angela

“…The inhibition activity of a series of anticancer metal complexes based on platinum, ruthenium, and gold metal ions was evaluated on the zinc-finger protein…”
Get full text