Tracing immature myelin in acute disseminated encephalomyelitis

Inherent abnormalities of myelin have been suggested in the pathogenesis of multiple sclerosis (MS). We investigated myelin in acute disseminated encephalomyelitis (ADEM) patients by magnetic resonance spectroscopy (MRS) and cerebrospinal fluid (CSF) analysis for citrulline, a marker of immature mye...

Full description

Saved in:

Bibliographic Details
Published in:	Turkish journal of pediatrics Vol. 48; no. 3; pp. 197 - 201
Main Authors:	Anlar, Banu, Karli-Oğuz, Kader, Yurtyapan, Osman Yücel, Senbil, Nesrin, Hergüner, Ozlem, Altunbaşak, Sakir, Sönmez, F Müjgan, Ozdemir-Geyik, Pinar
Format:	Journal Article
Language:	English
Published:	Turkey Hacettepe University Faculty of Medicine 01-07-2006
Subjects:	Adolescent Child Child, Preschool Chromatography, High Pressure Liquid Citrulline - metabolism Encephalomyelitis, Acute Disseminated - cerebrospinal fluid Encephalomyelitis, Acute Disseminated - metabolism Female Humans Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Male Myelin Sheath - metabolism
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Inherent abnormalities of myelin have been suggested in the pathogenesis of multiple sclerosis (MS). We investigated myelin in acute disseminated encephalomyelitis (ADEM) patients by magnetic resonance spectroscopy (MRS) and cerebrospinal fluid (CSF) analysis for citrulline, a marker of immature myelin. A citrulline peak was observed in the normal appearing white matter of 7/15 patients and of 1/10 age-matched neurological controls (p=0.08). CSF citrulline was elevated in 4/6 patients. Alterations in the composition of myelin might predispose to or follow acute inflammatory disorders of the central nervous system.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0041-4301