Search Results - "Yurova, Maria N."

Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice by Anisimov, Vladimir N., Zabezhinski, Mark A., Popovich, Irina G., Piskunova, Tatiana S., Semenchenko, Anna V., Tyndyk, Margarita L., Yurova, Maria N., Rosenfeld, Svetlana V., Blagosklonny, Mikhail V

“…The nutrient-sensing TO R (target of rapamycin) pathway is involved in cellular and organismal aging. Rapamycin, an inhibitor of TO R, extends lifespan in…”
Get full text

If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice by Anisimov, Vladimir N, Berstein, Lev M, Popovich, Irina G, Zabezhinski, Mark A, Egormin, Peter A, Piskunova, Tatiana S, Semenchenko, Anna V, Tyndyk, Margarita L, Yurova, Maria N, Kovalenko, Irina G, Poroshina, Tatiana E

“…Hyperglycemia and hyperinsulinemia accelerate both aging and cancer. Antidiabetic biguanides such as metformin decrease glucose, insulin and IGF-1 level…”
Get full text

Metformin extends life span of HER-2/neu transgenic mice and in combination with melatonin inhibits growth of transplantable tumors in vivo by Anisimov, Vladimir N., Egormin, Peter A., Piskunova, Tatiana S., Popovich, Irina G., Tyndyk, Margarita L., Yurova, Maria N., Zabezhinski, Mark A., Anikin, Ivan V., Karkach, Arseniy S., Romanyukha, Alexey A.

“…Population studies have shown that treatment with the antidiabetic biguanide metformin significantly reduced cancer risk. In our animal studies, metformin…”
Get full text

Effects of the mitochondria-targeted antioxidant SkQ1 on lifespan of rodents by Anisimov, Vladimir N, Egorov, Maxim V, Krasilshchikova, Marina S, Lyamzaev, Konstantin G, Manskikh, Vasily N, Moshkin, Mikhail P, Novikov, Evgeny A, Popovich, Irina G, Rogovin, Konstantin A, Shabalina, Irina G, Shekarova, Olga N, Skulachev, Maxim V, Titova, Tatiana V, Vygodin, Vladimir A, Vyssokikh, Mikhail Yu, Yurova, Maria N, Zabezhinsky, Mark A, Skulachev, Vladimir P

“…The effect of the mitochondria-targeted, plastoquinone-containing antioxidant SkQ1 on the lifespan of outbred mice and of three strains of inbred mice was…”
Get full text

Effects of Isoflavone-Rich NADES Extract of Pueraria lobata Roots and Astaxanthin-Rich Phaffia rhodozyma Extract on Prostate Carcinogenesis in Rats by Semenov, Alexander L, Tyndyk, Margarita L, Von, Julia D, Ermakova, Elena D, Dorofeeva, Anastasia A, Tumanyan, Irina A, Radetskaya, Ekaterina A, Yurova, Maria N, Zherebker, Alexander, Gorbunov, Alexander Yu, Fedoros, Elena I, Panchenko, Andrey V, Anisimov, Vladimir N

“…Prostate cancer (PCa) is one of the most common male malignancies worldwide. In the current study, we evaluated the effects of a natural deep eutectic solvent…”
Get full text

Astaxantin and Isoflavones Inhibit Benign Prostatic Hyperplasia in Rats by Reducing Oxidative Stress and Normalizing Ca/Mg Balance by Semenov, Alexander L, Gubareva, Ekaterina A, Ermakova, Elena D, Dorofeeva, Anastasia A, Tumanyan, Irina A, Radetskaya, Ekaterina A, Yurova, Maria N, Aboushanab, Saied A, Kanwugu, Osman N, Fedoros, Elena I, Panchenko, Andrey V

“…Benign prostatic hyperplasia (BPH) is a common pathology among aging men. Despite the broad pharmacological interventions, the available remedies to treat BPH…”
Get full text

Rapamycin Extends Maximal Lifespan in Cancer-Prone Mice by Anisimov, Vladimir N, Zabezhinski, Mark A, Popovich, Irina G, Piskunova, Tatiana S, Semenchenko, Anna V, Tyndyk, Margarita L, Yurova, Maria N, Antoch, Marina P, Blagosklonny, Mikhail V

“…Aging is associated with obesity and cancer. Calorie restriction both slows down aging and delays cancer. Evidence has emerged that the nutrient-sensing…”
Get full text

Lifespan extension and cancer prevention in HER-2/neu transgenic mice treated with low intermittent doses of rapamycin by Popovich, Irina G, Anisimov, Vladimir N, Zabezhinski, Mark A, Semenchenko, Anna V, Tyndyk, Margarita L, Yurova, Maria N, Blagosklonny, Mikhail V

“…Target of Rapamycin (TOR) is involved in cellular and organismal aging. Rapamycin extends lifespan and delays cancer in mice. It is important to determine the…”
Get full text

Assessment of antitumor activity of BP-C1, a platinum-based anticancer agent with a lignin-derived polymeric ligand, in autochthonous induced and spontaneous carcinogenesis rodent models by Fedoros, Elena I., Tyndyk, Margarita L., Popovich, Irina G., Anikin, Ivan V., Yurova, Maria N., Gubareva, Ekaterina A., Pigarev, Sergey E., Panchenko, Andrey V., Solovyev, Nikolay D., Anisimov, Vladimir N.

“…A standard approach to study the anticancer activity of novel drugs is their testing in animals with inoculated tumors, which has some limitations. An…”
Get full text

Sex differences in aging, life span and spontaneous tumorigenesis in 129/Sv mice neonatally exposed to metformin by Anisimov, Vladimir N, Popovich, Irina G, Zabezhinski, Mark A, Egormin, Peter A, Yurova, Maria N, Semenchenko, Anna V, Tyndyk, Margarita L, Panchenko, Andrey V, Trashkov, Alexandr P, Vasiliev, Andrey G, Khaitsev, Nikolai V

“…The perinatal (prenatal and early neonatal) period is a critical stage for hypothalamic programming of sexual differentiation as well as for the development of…”
Get full text

In mice transgenic for IGF1 under keratin-14 promoter, lifespan is decreased and the rates of aging and thymus involution are accelerated by Anisimov, Vladimir N, Labunets, Irina F, Popovich, Irina G, Tyndyk, Margarita L, Yurova, Maria N, Golubev, Alexey G

“…IGF1 signaling is supposedly a key lifespan determinant in metazoans. However, controversial lifespan data were obtained with different means used to modify…”
Get full text

Enchancement of Toremifene Anti-Tumor Action by Metformin and Unusual Side Effect of Toremifene in Male Transgenic Mice with HER2-Positive Breast Tumor by Stukov, Alexander N, Osipov, Mikhail A, Semiglazova, Tatjana Y, Filatova, Larisa V, Alexandrov, Valerij A, Bespalov, Vladimir G, Semenov, Alexander L, Tyndyk, Margarita L, Yurova, Maria N, Panchenko, Andrey V, Baranenko, Denis A

“…HER2-positive breast tumors are found in 25-30% of patients with breast cancer and are characterized by aggressive course and reduced sensitivity to both…”
Get more information

Polyphenolic drug composition based on benzenepolycarboxylic acids (BP-C3) increases life span and inhibits spontaneous tumorigenesis in female SHR mice by Anisimov, Vladimir N, Popovich, Irina G, Zabezhinski, Mark A, Yurova, Maria N, Tyndyk, Margarita L, Anikin, Ivan V, Egormin, Peter A, Baldueva, Irina A, Fedoros, Elena I, Pigarev, Sergey E, Panchenko, Andrey V

“…Effects of long-term application of novel polyphenolic composition BP-C3, containing polyphenolic benzenepolycarboxylic acids, vitamins and minerals on some…”
Get full text

Exposure to light at night accelerates aging and spontaneous uterine carcinogenesis in female 129/Sv mice by Popovich, Irina G., Zabezhinski, Mark A., Panchenko, Andrei V., Piskunova, Tatiana S., Semenchenko, Anna V., Tyndyk, Maragriata L., Yurova, Maria N., Anisimov, Vladimir N.

“…The effect of the constant illumination on the development of spontaneous tumors in female 129/Sv mice was investigated. Forty-six female 129/Sv mice starting…”
Get full text

Biomarkers of aging, life span and spontaneous carcinogenesis in the wild type and HER-2 transgenic FVB/N female mice by Panchenko, Andrey V., Popovich, Irina G., Trashkov, Alexandr P., Egormin, Peter A., Yurova, Maria N., Tyndyk, Margarita L., Gubareva, Ekaterina A., Artyukin, Ilia N., Vasiliev, Andrey G., Khaitsev, Nikolai V., Zabezhinski, Mark A., Anisimov, Vladimir N.

“…FVB/N wild type and transgenic HER-2/neu FVB/N female mice breed at N.N. Petrov Research Institute of Oncology were under observation until natural death…”
Get full text

Effect of the polyphenol composition BP-C3 on haematological and intestinal indicators of 5-fluorouracil toxicity in mice by Panchenko, Andrey V, Fedoros, Elena I, Pigarev, Sergey E, Maydin, Mikhail A, Gubareva, Ekaterina A, Yurova, Maria N, Kireeva, Galina S, Lanskikh, Galina P, Tyndyk, Margarita L, Anisimov, Vladimir N

“…BP-C3 is a formulation, which comprises lignin-derived polyphenolic composition of benzenepolycarboxylic acids (BP-Cx-1) with iron complex, selenium, ascorbic…”
Get full text

Deficiency in Poly(ADP-ribose) Polymerase-1 (PARP-1) Accelerates Aging and Spontaneous Carcinogenesis in Mice by Piskunova, Tatiana S., Yurova, Maria N., Ovsyannikov, Anton I., Semenchenko, Anna V., Zabezhinski, Mark A., Popovich, Irina G., Wang, Zhao-Qi, Anisimov, Vladimir N.

“…Genetic and biochemical studies have shown that PARP-1 and poly(ADP-ribosyl)ation play an important role in DNA repair, genomic stability, cell death,…”
Get full text

Rodent models for the preclinical evaluation of drugs suitable for pharmacological intervention in aging by Anisimov, Vladimir N, Zabezhinski, Mark A, Popovich, Irina G, Pliss, Gennady B, Bespalov, Vladimir G, Alexandrov, Valeri A, Stukov, Alexander N, Anikin, Ivan V, Alimova, Irina N, Egormin, Peter А, Panchenko, Andrey V, Piskunova, Tatiana S, Semenchenko, Anna V, Tyndyk, Margarita L, Yurova, Maria N

“…There is a growing scientific and public interest in the development of new antiaging drugs for the purposes of extending mean and/or maximum life span,…”
Get more information

Gender differences in metformin effect on aging, life span and spontaneous tumorigenesis in 129/Sv mice by Anisimov, Vladimir N, Piskunova, Tatiana S, Popovich, Irina G, Zabezhinski, Mark A, Tyndyk, Margarita L, Egormin, Peter A, Yurova, Maria V, Rosenfeld, Svetlana V, Semenchenko, Anna V, Kovalenko, Irina G, Poroshina, Tatiana E, Berstein, Lev M

“…Studies in mammals have led to the suggestion that hyperglycemia and hyperinsulinemia are important factors both in aging and in the development of cancer. It…”
Get full text

Effects of Isoflavone-Rich NADES Extract of IPueraria lobata/I Roots and Astaxanthin-Rich IPhaffia rhodozyma/I Extract on Prostate Carcinogenesis in Rats by Semenov, Alexander L, Tyndyk, Margarita L, Von, Julia D, Ermakova, Elena D, Dorofeeva, Anastasia A, Tumanyan, Irina A, Radetskaya, Ekaterina A, Yurova, Maria N, Zherebker, Alexander, Gorbunov, Alexander Yu, Fedoros, Elena I, Panchenko, Andrey V, Anisimov, Vladimir N

“…Prostate cancer (PCa) is one of the most common male malignancies worldwide. In the current study, we evaluated the effects of a natural deep eutectic solvent…”
Get full text