Search Results - "Yurko, Raymond"

Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicity by Izzo, Nicholas J, Xu, Jinbin, Zeng, Chenbo, Kirk, Molly J, Mozzoni, Kelsie, Silky, Colleen, Rehak, Courtney, Yurko, Raymond, Look, Gary, Rishton, Gilbert, Safferstein, Hank, Cruchaga, Carlos, Goate, Alison, Cahill, Michael A, Arancio, Ottavio, Mach, Robert H, Craven, Rolf, Head, Elizabeth, LeVine, 3rd, Harry, Spires-Jones, Tara L, Catalano, Susan M

“…Amyloid beta (Abeta) 1-42 oligomers accumulate in brains of patients with Mild Cognitive Impairment (MCI) and disrupt synaptic plasticity processes that…”
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Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers I: Abeta 42 oligomer binding to specific neuronal receptors is displaced by drug candidates that improve cognitive deficits by Izzo, Nicholas J, Staniszewski, Agnes, To, Lillian, Fa, Mauro, Teich, Andrew F, Saeed, Faisal, Wostein, Harrison, Walko, 3rd, Thomas, Vaswani, Anisha, Wardius, Meghan, Syed, Zanobia, Ravenscroft, Jessica, Mozzoni, Kelsie, Silky, Colleen, Rehak, Courtney, Yurko, Raymond, Finn, Patricia, Look, Gary, Rishton, Gilbert, Safferstein, Hank, Miller, Miles, Johanson, Conrad, Stopa, Edward, Windisch, Manfred, Hutter-Paier, Birgit, Shamloo, Mehrdad, Arancio, Ottavio, LeVine, 3rd, Harry, Catalano, Susan M

“…Synaptic dysfunction and loss caused by age-dependent accumulation of synaptotoxic beta amyloid (Abeta) 1-42 oligomers is proposed to underlie cognitive…”
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Modeling the mature CNS: A predictive screening platform for neurodegenerative disease drug discovery by LaBarbera, Kelsie Mozzoni, Limegrover, Colleen, Rehak, Courtney, Yurko, Raymond, Izzo, Nicholas John, Knezovich, Nicole, Watto, Emily, Waybright, Lora, Catalano, Susan M.

“…Mature primary neuronal cultures are an important model of the nervous system, but limited scalability has been a major challenge in their use for drug…”
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Cardiac Targeting Peptide, a Novel Cardiac Vector: Studies in Bio-Distribution, Imaging Application, and Mechanism of Transduction by Zahid, Maliha, Feldman, Kyle S, Garcia-Borrero, Gabriel, Feinstein, Timothy N, Pogodzinski, Nicholas, Xu, Xinxiu, Yurko, Raymond, Czachowski, Michael, Wu, Yijen L, Mason, Neale S, Lo, Cecilia W

“…Our previous work identified a 12-amino acid peptide that targets the heart, termed cardiac targeting peptide (CTP). We now quantitatively assess the…”
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Sigma‐2 receptor antagonists rescue neuronal dysfunction induced by Parkinson’s patient brain‐derived α‐synuclein by Limegrover, Colleen S., Yurko, Raymond, Izzo, Nicholas J., LaBarbera, Kelsie M., Rehak, Courtney, Look, Gary, Rishton, Gilbert, Safferstein, Hank, Catalano, Susan M.

“…α‐Synuclein oligomers are thought to have a pivotal role in sporadic and familial Parkinson's disease (PD) and related α‐synucleinopathies, causing…”
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Alzheimer’s protection effect of A673T mutation may be driven by lower Aβ oligomer binding affinity by Limegrover, Colleen S., LeVine, Harry, Izzo, Nicholas J., Yurko, Raymond, Mozzoni, Kelsie, Rehak, Courtney, Sadlek, Kelsey, Safferstein, Hank, Catalano, Susan M.

“…Several mutations conferring protection against Alzheimer's disease (AD) have been described, none as profound as the A673T mutation, where carriers are four…”
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Preclinical and clinical biomarker studies of CT1812: A novel approach to Alzheimer's disease modification by Izzo, Nicholas J., Yuede, Carla M., LaBarbera, Kelsie M., Limegrover, Colleen S., Rehak, Courtney, Yurko, Raymond, Waybright, Lora, Look, Gary, Rishton, Gilbert, Safferstein, Hank, Hamby, Mary E., Williams, Claire, Sadlek, Kelsey, Edwards, Hannah M., Davis, Charles S., Grundman, Michael, Schneider, Lon S., DeKosky, Steven T., Chelsky, Daniel, Pike, Ian, Henstridge, Christopher, Blennow, Kaj, Zetterberg, Henrik, LeVine, Harry, Spires‐Jones, Tara L., Cirrito, John R., Catalano, Susan M.

“…Introduction Amyloid beta (Aβ) oligomers are one of the most toxic structural forms of the Aβ protein and are hypothesized to cause synaptotoxicity and memory…”
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Discovery of Investigational Drug CT1812, an Antagonist of the Sigma‑2 Receptor Complex for Alzheimer’s Disease by Rishton, Gilbert M, Look, Gary C, Ni, Zhi-Jie, Zhang, Jason, Wang, Yingcai, Huang, Yaodong, Wu, Xiaodong, Izzo, Nicholas J, LaBarbera, Kelsie M, Limegrover, Colleen S, Rehak, Courtney, Yurko, Raymond, Catalano, Susan M

“…An unbiased phenotypic neuronal assay was developed to measure the synaptotoxic effects of soluble Aβ oligomers. A collection of CNS druglike small molecules…”
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Selection of a potential diagnostic biomarker for HIV infection from a random library of non-biological synthetic peptoid oligomers by Gearhart, Tricia L., Montelaro, Ronald C., Schurdak, Mark E., Pilcher, Chris D., Rinaldo, Charles R., Kodadek, Thomas, Park, Yongseok, Islam, Kazi, Yurko, Raymond, Marques, Ernesto T.A., Burke, Donald S.

“…Non-biological synthetic oligomers can serve as ligands for antibodies. We hypothesized that a random combinatorial library of synthetic poly-N-substituted…”
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A phase 1b randomized clinical trial of CT1812 to measure Aβ oligomer displacement in Alzheimer's disease using an indwelling CSF catheter by LaBarbera, Kelsie M, Sheline, Yvette I, Izzo, Nicholas J, Yuede, Carla M, Waybright, Lora, Yurko, Raymond, Edwards, Hannah M, Gardiner, Woodrow D, Blennow, Kaj, Zetterberg, Henrik, Börjesson-Hanson, Anne, Morgan, Roger, Davis, Charles S, Guttendorf, Robert J, Schneider, Lon S, DeKosky, Steven, LeVine, 3rd, Harry, Grundman, Michael, Caggiano, Anthony O, Cirrito, John R, Catalano, Susan M, Hamby, Mary E

“…In support of this, Aβ oligomer reduction in an AD mouse model leads to memory preservation [2, 3], and clinical benefit was in trials of lecanemab, which…”
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An Abeta Oligomer Receptor Antagonist and Antibodies to Specific Target Receptor Epitopes Displace Abeta Oligomers in Alzheimer’s Patient Brain Tissue Sections (S38.006) by Catalano, Susan, Izzo, Nicholas, Rehak, Courtney, Yurko, Raymond, Mozzoni, Kelsie, Silky, Colleen, Look, Gary, Rishton, Gilbert, Safferstein, Hank, Spires-Jones, Tara

“…Abstract only…”
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An Abeta Oligomer Receptor Antagonist and Antibodies to Specific Target Receptor Epitopes Displace Abeta Oligomers in Alzheimer’s Patient Brain Tissue Sections (I11-1.001) by Catalano, Susan, Izzo, Nicholas, Rehak, Courtney, Yurko, Raymond, Mozzoni, Kelsie, Silky, Colleen, Look, Gary, Rishton, Gilbert, Safferstein, Hank, Spires-Jones, Tara

“…Abstract only…”
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P4‐091: Novel Anti‐oligomer Compounds Stop Memory Deficits by Catalano, Susan M., Ravesncroft, Jessica, Rehak, Courtney, Yurko, Raymond, Izzo, Nicholas, Safferstein, Hank, Rishton, Gilbert, Staniszewski, Agnes, Arancio, Ottavio

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Abstract 14296: Cardiac Targeting Peptide, a Novel Cardiac Vector: Studies in Biodistribution, Mechanisms of Transduction and Imaging Application by Zahid, Maliha, Feldman, Kyle, Feinstein, Timothy N, Pogodzinski, Nicholas, Xu, Xinxiu, Yurko, Raymond, Czachowski, Michael R, Wu, Yijen, Lo, Cecilia W, Mason, Neal S

“…BackgroundCardiac diagnostics and therapeutics are limited by lack of a specific vector targeting the heart. Our previous work utilizing phage display…”
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Novel Anti-oligomer Compounds Stop Memory Deficits by Catalano, Susan M, Ravesncroft, Jessica, Rehak, Courtney, Yurko, Raymond, Izzo, Nicholas, Safferstein, Hank, Rishton, Gilbert, Staniszewski, Agnes, Arancio, Ottavio

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