Search Results - "Yurek, D.M."

Transgene expression in the striatum following intracerebral injections of DNA nanoparticles encoding for human glial cell line-derived neurotrophic factor by Fletcher, A.M, Kowalczyk, T.H, Padegimas, L, Cooper, M.J, Yurek, D.M

“…Abstract A goal of our studies is to develop a potential therapeutic for Parkinson's disease (PD) by a human glial cell line-derived neurotrophic factor…”
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Age and lesion-induced increases of GDNF transgene expression in brain following intracerebral injections of DNA nanoparticles by Yurek, D.M, Hasselrot, U, Cass, W.A, Sesenoglu-Laird, O, Padegimas, L, Cooper, M.J

“…Highlights • Transgene expression in brain is sensitive to aging and pathology. • Transgene expression in astrocytes increases directly with age and severity…”
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Long distance directional growth of dopaminergic axons along pathways of netrin-1 and GDNF by Zhang, C., Jin, Y., Ziemba, K.S., Fletcher, A.M., Ghosh, B., Truit, E., Yurek, D.M., Smith, G.M.

“…Different experimental and clinical strategies have been used to promote survival of transplanted embryonic ventral mesencephalic (VM) neurons. However, few…”
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Behavioral demonstration of a reciprocal interaction between dopamine receptor subtypes in the mouse striatum: possible involvement of the striato-nigral pathway by Mandel, R J, Yurek, D M, Randall, P K

“…It is well known that stimulation of the D-2 dopamine receptor in vitro inhibits the increased efflux of cyclic adenosine monophosphate caused by D-1 receptor…”
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