Search Results - "Yunshu, Che"
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Single-cell RNA sequencing analysis of human bone-marrow-derived mesenchymal stem cells and functional subpopulation identification
Published in Experimental & molecular medicine (01-04-2022)“…Mesenchymal stem cells (MSCs) are a common kind of multipotent cell in vivo, but their heterogeneity limits their further applications. To identify MSC…”
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TNF-α-mediated m6A modification of ELMO1 triggers directional migration of mesenchymal stem cell in ankylosing spondylitis
Published in Nature communications (10-09-2021)“…Ankylosing spondylitis (AS) is a type of rheumatic disease characterized by chronic inflammation and pathological osteogenesis in the entheses. Previously, we…”
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ALKBH5 facilitates CYP1B1 mRNA degradation via m6A demethylation to alleviate MSC senescence and osteoarthritis progression
Published in Experimental & molecular medicine (01-08-2023)“…Improving health and delaying aging is the focus of medical research. Previous studies have shown that mesenchymal stem cell (MSC) senescence is closely…”
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Variations in the Gut Microbiota in Breast Cancer Occurrence and Bone Metastasis
Published in Frontiers in microbiology (26-05-2022)“…Breast cancer is the most common cancer in women and the second most common cancer overall. Although advancements in the early diagnosis and therapy of breast…”
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Targeting macrophage M1 polarization suppression through PCAF inhibition alleviates autoimmune arthritis via synergistic NF-κB and H3K9Ac blockade
Published in Journal of nanobiotechnology (19-08-2023)“…Abstract Sustained inflammatory invasion leads to joint damage and progressive disability in several autoimmune rheumatic diseases. In recent decades,…”
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Osteogenic differentiation of mesenchymal stem cells promotes c-Jun-dependent secretion of interleukin 8 and mediates the migration and differentiation of CD4 + T cells
Published in Stem cell research & therapy (05-02-2022)“…The immune system and the skeletal system have complex interactions in the bone marrow and even in the joints, which has promoted the development of the…”
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LncRNA MRF drives the regulatory function on monocyte recruitment and polarization through HNRNPD-MCP1 axis in mesenchymal stem cells
Published in Journal of biomedical science (21-09-2022)“…Abstract Background Mesenchymal stem cells (MSCs) exhibit two bidirectional immunomodulatory abilities: proinflammatory and anti-inflammatory regulatory…”
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Decrotonylation of AKT1 promotes AKT1 phosphorylation and activation during myogenic differentiation
Published in Journal of advanced research (01-08-2023)“…[Display omitted] •Gradual decrease in total protein crotonylation level was observed during muscle differentiation.•Decreased crotonylation of AKT1…”
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TNF‐α‐Induced KAT2A Impedes BMMSC Quiescence by Mediating Succinylation of the Mitophagy‐Related Protein VCP
Published in Advanced science (01-03-2024)“…Regular quiescence and activation are important for the function of bone marrow mesenchymal stem cells (BMMSC), multipotent stem cells that are widely used in…”
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BMAL1-TTK-H2Bub1 loop deficiency contributes to impaired BM-MSC-mediated bone formation in senile osteoporosis
Published in Molecular therapy. Nucleic acids (14-03-2023)“…During the aging process, the reduced osteogenic differentiation of bone marrow mesenchymal stem cells (BM-MSCs) results in decreased bone formation, which…”
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Super enhancers targeting ZBTB16 in osteogenesis protect against osteoporosis
Published in Bone Research (07-06-2023)“…As the major cell precursors in osteogenesis, mesenchymal stem cells (MSCs) are indispensable for bone homeostasis and development. However, the primary…”
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Author Correction: Super enhancers targeting ZBTB16 in osteogenesis protect against osteoporosis
Published in Bone Research (26-06-2023)Get full text
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The m6A methyltransferase METTL16 negatively regulates MCP1 expression in mesenchymal stem cells during monocyte recruitment
Published in JCI insight (22-03-2023)“…Mesenchymal stem cells (MSCs) possess strong immunoregulatory functions, one aspect of which is recruiting monocytes from peripheral vessels to local tissue by…”
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Iron-dependent KDM4D activity controls the quiescence-activity balance of MSCs via the PI3K-Akt-Foxo1 pathway
Published in Cellular and molecular life sciences : CMLS (19-08-2024)“…Iron deficiency is a prevalent nutritional deficit associated with organ damage and dysfunction. Recent research increasingly associates iron deficiency with…”
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SNP-adjacent super enhancer network mediates enhanced osteogenic differentiation of MSCs in ankylosing spondylitis
Published in Human molecular genetics (26-04-2021)“…Abstract Ankylosing spondylitis (AS) is a rheumatic disease with pathological osteogenesis that causes bony ankylosis and even deformity over time. Mesenchymal…”
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Targeting macrophage M1 polarization suppression through PCAF inhibition alleviates autoimmune arthritis via synergistic NF-κB and H3K9Ac blockade
Published in Journal of nanobiotechnology (19-08-2023)“…Sustained inflammatory invasion leads to joint damage and progressive disability in several autoimmune rheumatic diseases. In recent decades, targeting M1…”
Get full text
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Targeting macrophage M1 polarization suppression through PCAF inhibition alleviates autoimmune arthritis via synergistic NF-?B and H3K9Ac blockade
Published in Journal of nanobiotechnology (19-08-2023)“…Sustained inflammatory invasion leads to joint damage and progressive disability in several autoimmune rheumatic diseases. In recent decades, targeting M1…”
Get full text
Journal Article