Search Results - "Yunshu, Che"

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    Single-cell RNA sequencing analysis of human bone-marrow-derived mesenchymal stem cells and functional subpopulation identification by Xie, Zhongyu, Yu, Wenhui, Ye, Guiwen, Li, Jinteng, Zheng, Guan, Liu, Wenjie, Lin, Jiajie, Su, Zepeng, Che, Yunshu, Ye, Feng, Zhang, Zhaoqiang, Wang, Peng, Wu, Yanfeng, Shen, Huiyong

    Published in Experimental & molecular medicine (01-04-2022)
    “…Mesenchymal stem cells (MSCs) are a common kind of multipotent cell in vivo, but their heterogeneity limits their further applications. To identify MSC…”
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    Journal Article
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    TNF-α-mediated m6A modification of ELMO1 triggers directional migration of mesenchymal stem cell in ankylosing spondylitis by Xie, Zhongyu, Yu, Wenhui, Zheng, Guan, Li, Jinteng, Cen, Shuizhong, Ye, Guiwen, Li, Zhaofeng, Liu, Wenjie, Li, Ming, Lin, Jiajie, Su, Zepeng, Che, Yunshu, Ye, Feng, Wang, Peng, Wu, Yanfeng, Shen, Huiyong

    Published in Nature communications (10-09-2021)
    “…Ankylosing spondylitis (AS) is a type of rheumatic disease characterized by chronic inflammation and pathological osteogenesis in the entheses. Previously, we…”
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    ALKBH5 facilitates CYP1B1 mRNA degradation via m6A demethylation to alleviate MSC senescence and osteoarthritis progression by Ye, Guiwen, Li, Jinteng, Yu, Wenhui, Xie, Zhongyu, Zheng, Guan, Liu, Wenjie, Wang, Shan, Cao, Qian, Lin, Jiajie, Su, Zepeng, Li, Dateng, Che, Yunshu, Fan, Shuai, Wang, Peng, Wu, Yanfeng, Shen, Huiyong

    Published in Experimental & molecular medicine (01-08-2023)
    “…Improving health and delaying aging is the focus of medical research. Previous studies have shown that mesenchymal stem cell (MSC) senescence is closely…”
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    Variations in the Gut Microbiota in Breast Cancer Occurrence and Bone Metastasis by Wenhui, Yu, Zhongyu, Xie, Kai, Chen, Zhaopeng, Cai, Jinteng, Li, Mengjun, Ma, Zepeng, Su, Yunshu, Che, Peng, Wang, Yanfeng, Wu, Huiyong, Shen

    Published in Frontiers in microbiology (26-05-2022)
    “…Breast cancer is the most common cancer in women and the second most common cancer overall. Although advancements in the early diagnosis and therapy of breast…”
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    LncRNA MRF drives the regulatory function on monocyte recruitment and polarization through HNRNPD-MCP1 axis in mesenchymal stem cells by Lin, Jiajie, Xie, Zhongyu, Zhang, Zhaoqiang, Li, Ming, Ye, Guiwen, Yu, Wenhui, Li, Jinteng, Ye, Feng, Su, Zepeng, Che, Yunshu, Xu, Peitao, Zeng, Chenying, Wang, Peng, Wu, Yanfeng, Shen, Huiyong

    Published in Journal of biomedical science (21-09-2022)
    “…Abstract Background Mesenchymal stem cells (MSCs) exhibit two bidirectional immunomodulatory abilities: proinflammatory and anti-inflammatory regulatory…”
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    Decrotonylation of AKT1 promotes AKT1 phosphorylation and activation during myogenic differentiation by Qian, Zhengyu, Ye, Jingwei, Li, Jinteng, Che, Yunshu, Yu, Wenhui, Xu, Peitao, Lin, Jiajie, Ye, Feng, Xu, Xiaojun, Su, Zepeng, Li, Dateng, Xie, Zhongyu, Wu, Yanfeng, Shen, Huiyong

    Published in Journal of advanced research (01-08-2023)
    “…[Display omitted] •Gradual decrease in total protein crotonylation level was observed during muscle differentiation.•Decreased crotonylation of AKT1…”
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    TNF‐α‐Induced KAT2A Impedes BMMSC Quiescence by Mediating Succinylation of the Mitophagy‐Related Protein VCP by Su, Zepeng, Li, Jinteng, Lin, Jiajie, Li, Zhikun, Che, Yunshu, Zhang, Zhaoqiang, Zheng, Guan, Ye, Guiwen, Yu, Wenhui, Zeng, Yipeng, Xu, Peitao, Xu, Xiaojun, Xie, Zhongyu, Wu, Yanfeng, Shen, Huiyong

    Published in Advanced science (01-03-2024)
    “…Regular quiescence and activation are important for the function of bone marrow mesenchymal stem cells (BMMSC), multipotent stem cells that are widely used in…”
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    BMAL1-TTK-H2Bub1 loop deficiency contributes to impaired BM-MSC-mediated bone formation in senile osteoporosis by Jinteng, Li, Peitao, Xu, Wenhui, Yu, Guiwen, Ye, Feng, Ye, Xiaojun, Xu, Zepeng, Su, Jiajie, Lin, Yunshu, Che, Zhaoqiang, Zhang, Yipeng, Zeng, Zhikun, Li, Pei, Feng, Qian, Cao, Dateng, Li, Zhongyu, Xie, Yanfeng, Wu, Huiyong, Shen

    Published in Molecular therapy. Nucleic acids (14-03-2023)
    “…During the aging process, the reduced osteogenic differentiation of bone marrow mesenchymal stem cells (BM-MSCs) results in decreased bone formation, which…”
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    Super enhancers targeting ZBTB16 in osteogenesis protect against osteoporosis by Yu, Wenhui, Xie, Zhongyu, Li, Jinteng, Lin, Jiajie, Su, Zepeng, Che, Yunshu, Ye, Feng, Zhang, Zhaoqiang, Xu, Peitao, Zeng, Yipeng, Xu, Xiaojun, Li, Zhikun, Feng, Pei, Mi, Rujia, Wu, Yanfeng, Shen, Huiyong

    Published in Bone Research (07-06-2023)
    “…As the major cell precursors in osteogenesis, mesenchymal stem cells (MSCs) are indispensable for bone homeostasis and development. However, the primary…”
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    The m6A methyltransferase METTL16 negatively regulates MCP1 expression in mesenchymal stem cells during monocyte recruitment by Zhang, Zhaoqiang, Xie, Zhongyu, Lin, Jiajie, Sun, Zehang, Li, Zhikun, Yu, Wenhui, Zeng, Yipeng, Ye, Guiwen, Li, Jinteng, Ye, Feng, Su, Zepeng, Che, Yunshu, Xu, Peitao, Zeng, Chenying, Wang, Peng, Wu, Yanfeng, Shen, Huiyong

    Published in JCI insight (22-03-2023)
    “…Mesenchymal stem cells (MSCs) possess strong immunoregulatory functions, one aspect of which is recruiting monocytes from peripheral vessels to local tissue by…”
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    Iron-dependent KDM4D activity controls the quiescence-activity balance of MSCs via the PI3K-Akt-Foxo1 pathway by Xie, Zhongyu, Che, Yunshu, Huang, Guo, Su, Zepeng, Lin, Jiajie, Zheng, Guan, Ye, Guiwen, Yu, Wenhui, Li, Jinteng, Wu, Yanfeng, Shen, Huiyong

    “…Iron deficiency is a prevalent nutritional deficit associated with organ damage and dysfunction. Recent research increasingly associates iron deficiency with…”
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    SNP-adjacent super enhancer network mediates enhanced osteogenic differentiation of MSCs in ankylosing spondylitis by Yu, Wenhui, Chen, Keng, Ye, Guiwen, Wang, Shan, Wang, Peng, Li, Jinteng, Zheng, Guan, Liu, Wenjie, Lin, Jiajie, Su, Zepeng, Che, Yunshu, Ye, Feng, Ma, Mengjun, Xie, Zhongyu, Shen, Huiyong

    Published in Human molecular genetics (26-04-2021)
    “…Abstract Ankylosing spondylitis (AS) is a rheumatic disease with pathological osteogenesis that causes bony ankylosis and even deformity over time. Mesenchymal…”
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    Journal Article
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