Search Results - "Yung Gee, Heon"

SGLT2 inhibition modulates NLRP3 inflammasome activity via ketones and insulin in diabetes with cardiovascular disease by Kim, So Ra, Lee, Sang-Guk, Kim, Soo Hyun, Kim, Jin Hee, Choi, Eunhye, Cho, Wonhee, Rim, John Hoon, Hwang, Inhwa, Lee, Chan Joo, Lee, Minyoung, Oh, Chang-Myung, Jeon, Justin Y., Gee, Heon Yung, Kim, Jeong-Ho, Lee, Byung-Wan, Kang, Eun Seok, Cha, Bong-Soo, Lee, Myung-Shik, Yu, Je-Wook, Cho, Jin Won, Kim, Jung-Sun, Lee, Yong-ho

“…Sodium–glucose cotransporter 2 (SGLT2) inhibitors reduce cardiovascular events in humans with type 2 diabetes (T2D); however, the underlying mechanism remains…”
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Lactobacillus plantarum ameliorates NASH-related inflammation by upregulating l-arginine production by Kim, Dong Yun, Park, Jun Yong, Gee, Heon Yung

“…Lactobacillus is a probiotic with therapeutic potential for several diseases, including liver disease. However, the therapeutic effect of L. plantarum against…”
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Secreted metalloproteases ADAMTS9 and ADAMTS20 have a non-canonical role in ciliary vesicle growth during ciliogenesis by Nandadasa, Sumeda, Kraft, Caroline M., Wang, Lauren W., O’Donnell, Anna, Patel, Rushabh, Gee, Heon Yung, Grobe, Kay, Cox, Timothy C., Hildebrandt, Friedhelm, Apte, Suneel S.

“…Although hundreds of cytosolic or transmembrane molecules form the primary cilium, few secreted molecules are known to contribute to ciliogenesis. Here,…”
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Insulin-activated store-operated Ca2+ entry via Orai1 induces podocyte actin remodeling and causes proteinuria by Kim, Ji-Hee, Hwang, Kyu-Hee, Dang, Bao T. N., Eom, Minseob, Kong, In Deok, Gwack, Yousang, Yu, Seyoung, Gee, Heon Yung, Birnbaumer, Lutz, Park, Kyu-Sang, Cha, Seung-Kuy

“…Podocyte, the gatekeeper of the glomerular filtration barrier, is a primary target for growth factor and Ca 2+ signaling whose perturbation leads to…”
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Defects of CRB2 Cause Steroid-Resistant Nephrotic Syndrome by Ebarasi, Lwaki, Ashraf, Shazia, Bierzynska, Agnieszka, Gee, Heon Yung, McCarthy, Hugh J., Lovric, Svjetlana, Sadowski, Carolin E., Pabst, Werner, Vega-Warner, Virginia, Fang, Humphrey, Koziell, Ania, Simpson, Michael A., Dursun, Ismail, Serdaroglu, Erkin, Levy, Shawn, Saleem, Moin A., Hildebrandt, Friedhelm, Majumdar, Arindam

“…Nephrotic syndrome (NS), the association of gross proteinuria, hypoalbuminaemia, edema, and hyperlipidemia, can be clinically divided into steroid-sensitive…”
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COCH-related autosomal dominant nonsyndromic hearing loss: a phenotype–genotype study by Oh, Kyung Seok, Walls, Daniel, Joo, Sun Young, Kim, Jung Ah, Yoo, Jee Eun, Koh, Young Ik, Kim, Da Hye, Rim, John Hoon, Choi, Hye Ji, Kim, Hye-Youn, Yu, Seyoung, Smith, Richard J., Choi, Jae Young, Gee, Heon Yung, Jung, Jinsei

“…This phenotype–genotype study aimed to investigate the extent of audioprofile variability related to cochlin major domains and to identify potential…”
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PLCE1 regulates the migration, proliferation, and differentiation of podocytes by Yu, Seyoung, Choi, Won-Il, Choi, Yo Jun, Kim, Hye-Youn, Hildebrandt, Friedhelm, Gee, Heon Yung

“…PLCE1 encodes phospholipase C epsilon, and its mutations cause recessive nephrotic syndrome. However, the mechanisms by which PLCE1 mutations result in defects…”
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Mutations of CEP83 Cause Infantile Nephronophthisis and Intellectual Disability by Failler, Marion, Gee, Heon Yung, Krug, Pauline, Joo, Kwangsic, Halbritter, Jan, Belkacem, Lilya, Filhol, Emilie, Porath, Jonathan D., Braun, Daniela A., Schueler, Markus, Frigo, Amandine, Alibeu, Olivier, Masson, Cécile, Brochard, Karine, Hurault de Ligny, Bruno, Novo, Robert, Pietrement, Christine, Kayserili, Hulya, Salomon, Rémi, Gubler, Marie-Claire, Otto, Edgar A., Antignac, Corinne, Kim, Joon, Benmerah, Alexandre, Hildebrandt, Friedhelm, Saunier, Sophie

“…Ciliopathies are a group of hereditary disorders associated with defects in cilia structure and function. The distal appendages (DAPs) of centrioles are…”
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Grasp55−/− mice display impaired fat absorption and resistance to high-fat diet-induced obesity by Kim, Jiyoon, Kim, Hyeyon, Noh, Shin Hye, Jang, Dong Geon, Park, Shi-Young, Min, Dongkook, Kim, Hyunki, Kweon, Hee-Seok, Kim, Hoguen, Aum, Sowon, Seo, Sookyung, Choi, Cheol Soo, Kim, Hail, Kim, Jae Woo, Moon, Seok Jun, Gee, Heon Yung, Lee, Min Goo

“…The Golgi apparatus plays a central role in the intracellular transport of macromolecules. However, molecular mechanisms of Golgi-mediated lipid transport…”
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Genetic Predisposition to Sporadic Congenital Hearing Loss in a Pediatric Population by Jung, Jinsei, Lee, Joon Suk, Cho, Kyeong Jee, Yu, Seyoung, Yoon, Joo-Heon, Yung Gee, Heon, Choi, Jae Young

“…Discriminating between inherited and non-inherited sporadic hearing loss is challenging. Here, we attempted to delineate genetic inheritance in simplex cases…”
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Novel KCNQ4 variants in different functional domains confer genotype- and mechanism-based therapeutics in patients with nonsyndromic hearing loss by Lee, Sang-Yeon, Choi, Hyun Been, Park, Mina, Choi, Il Soon, An, Jieun, Kim, Ami, Kim, Eunku, Kim, Nahyun, Han, Jin Hee, Kim, Min young, Lee, Seung min, Oh, Doo-Yi, Kim, Bong Jik, Yi, Nayoung, Kim, Nayoung, K. D., Lee, Chung, Park, Woong-Yang, Koh, Young Ik, Gee, Heon Yung, Cho, Hyun Sung, Kang, Tong Mook, Choi, Byung Yoon

“…Loss-of-function variant in the gene encoding the KCNQ4 potassium channel causes autosomal dominant nonsyndromic hearing loss (DFNA2), and no effective…”
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Overlooked KCNQ4 variants augment the risk of hearing loss by Oh, Kyung Seok, Roh, Jae Won, Joo, Sun Young, Ryu, Kunhi, Kim, Jung Ah, Kim, Se Jin, Jang, Seung Hyun, Koh, Young Ik, Kim, Da Hye, Kim, Hye-Youn, Choi, Murim, Jung, Jinsei, Namkung, Wan, Nam, Joo Hyun, Choi, Jae Young, Gee, Heon Yung

“…Pathogenic variants of KCNQ4 cause symmetrical, late-onset, progressive, high-frequency-affected hearing loss, which eventually involves all frequencies with…”
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Unconventional protein secretion - new insights into the pathogenesis and therapeutic targets of human diseases by Kim, Jiyoon, Gee, Heon Yung, Lee, Min Goo

“…Most secretory proteins travel through a well-documented conventional secretion pathway involving the endoplasmic reticulum (ER) and the Golgi complex…”
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Rescue of ΔF508-CFTR Trafficking via a GRASP-Dependent Unconventional Secretion Pathway by Gee, Heon Yung, Noh, Shin Hye, Tang, Bor Luen, Kim, Kyung Hwan, Lee, Min Goo

“…The most prevalent disease-causing mutation of CFTR is the deletion of Phe508 (ΔF508), which leads to defects in conventional Golgi-mediated exocytosis and…”
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Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function by Won, Hyejung, Lee, Hye-Ryeon, Gee, Heon Yung, Mah, Won, Kim, Jae-Ick, Lee, Jiseok, Ha, Seungmin, Chung, Changuk, Jung, Eun Suk, Cho, Yi Sul, Park, Sae-Geun, Lee, Jung-Soo, Lee, Kyungmin, Kim, Daesoo, Bae, Yong Chul, Kaang, Bong-Kiun, Lee, Min Goo, Kim, Eunjoon

“…Mutations in SHANK2 have been associated with autism spectrum disorders in humans; here, Shank2 mutant mice are shown to exhibit autistic-like behaviours that…”
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A synonymous variation in protease-activated receptor-2 is associated with atopy in Korean children by Lee, Ji Hyun, PhD, Kim, Kyung Won, MD, PhD, Gee, Heon Yung, MD, PhD, Lee, Jaechun, MD, Lee, Keun-Hwa, PhD, Park, Hae-Sim, MD, PhD, Kim, Seung-Hyun, PhD, Kim, So Won, MD, Kim, Mi Na, Kim, Kyu-Earn, MD, PhD, Kim, Kyung Hwan, MD, PhD, Lee, Min Goo, MD, PhD, Sohn, Myung Hyun, MD, PhD

“…Background Atopic diseases are the most common chronic diseases of childhood, and the genetics of atopy are complex and heterogeneous. Protease-activated…”
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A single-gene cause in 29.5% of cases of steroid-resistant nephrotic syndrome by Sadowski, Carolin E, Lovric, Svjetlana, Ashraf, Shazia, Pabst, Werner L, Gee, Heon Yung, Kohl, Stefan, Engelmann, Susanne, Vega-Warner, Virginia, Fang, Humphrey, Halbritter, Jan, Somers, Michael J, Tan, Weizhen, Shril, Shirlee, Fessi, Inès, Lifton, Richard P, Bockenhauer, Detlef, El-Desoky, Sherif, Kari, Jameela A, Zenker, Martin, Kemper, Markus J, Mueller, Dominik, Fathy, Hanan M, Soliman, Neveen A, Hildebrandt, Friedhelm

“…Steroid-resistant nephrotic syndrome (SRNS) is the second most frequent cause of ESRD in the first two decades of life. Effective treatment is lacking. First…”
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PARK2 as a susceptibility factor for nontuberculous mycobacterial pulmonary disease by Park, Youngmok, Hong, Ji Won, Ahn, Eunsol, Gee, Heon Yung, Kang, Young Ae

“…The genetic signatures associated with the susceptibility to nontuberculous mycobacterial pulmonary disease (NTM-PD) are still unknown. In this study, we…”
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Mutations in DZIP1L, which encodes a ciliary-transition-zone protein, cause autosomal recessive polycystic kidney disease by Lu, Hao, Galeano, Maria C Rondón, Ott, Elisabeth, Kaeslin, Geraldine, Kausalya, P Jaya, Kramer, Carina, Ortiz-Brüchle, Nadina, Hilger, Nadescha, Metzis, Vicki, Hiersche, Milan, Tay, Shang Yew, Tunningley, Robert, Vij, Shubha, Courtney, Andrew D, Whittle, Belinda, Wühl, Elke, Vester, Udo, Hartleben, Björn, Neuber, Steffen, Frank, Valeska, Little, Melissa H, Epting, Daniel, Papathanasiou, Peter, Perkins, Andrew C, Wright, Graham D, Hunziker, Walter, Gee, Heon Yung, Otto, Edgar A, Zerres, Klaus, Hildebrandt, Friedhelm, Roy, Sudipto, Wicking, Carol, Bergmann, Carsten

“…Sudipto Roy, Carol Wicking, Carsten Bergmann and colleagues report that mutations in DZIP1L cause autosomal recessive polycystic kidney disease (ARPKD)…”
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Deep learning outperforms kidney organoid experts by Yu, Seyoung, Gee, Heon Yung

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