Search Results - "Yun, Theodore"

Preclinical Characterization of XL092, a Novel Receptor Tyrosine Kinase Inhibitor of MET, VEGFR2, AXL, and MER by Hsu, Jeff, Chong, Colin, Serrill, Jeffrey, Goon, Levina, Balayan, Joan, Johnson, Eric N, Lorenzana, Grachelle, Wu, Sharon, Leong, Kevin G, Yun, Theodore J, Wang, Yong, Jiang, Faming, Bannen, Lynne, Lamb, Peter, Xu, Wei, Yu, Peiwen

“…The multi-receptor tyrosine kinase inhibitor XL092 has been developed to inhibit the activity of oncogenic targets, including MET, VEGFR2, and the TAM family…”
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EC144, a synthetic inhibitor of heat shock protein 90, blocks innate and adaptive immune responses in models of inflammation and autoimmunity by Yun, Theodore J, Harning, Erin K, Giza, Keith, Rabah, Dania, Li, Ping, Arndt, Joseph W, Luchetti, David, Biamonte, Marco A, Shi, Jiandong, Lundgren, Karen, Manning, Anthony, Kehry, Marilyn R

“…Heat shock protein 90 (Hsp90) is a molecular chaperone involved in folding and stabilizing multiple intracellular proteins that have roles in cell activation…”
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The Distinct and Cooperative Roles of Toll-Like Receptor 9 and Receptor for Advanced Glycation End Products in Modulating In Vivo Inflammatory Responses to Select CpG and Non-CpG Oligonucleotides by Paz, Suzanne, Hsiao, Jill, Cauntay, Patrick, Soriano, Armand, Bai, Lawrence, Machemer, Todd, Xiao, Xiaokun, Guo, Shuling, Hung, Gene, Younis, Husam, Bennett, C Frank, Henry, Scott, Yun, Theodore J, Burel, Sébastien

“…Antisense oligonucleotides (ASOs) are widely accepted therapeutic agents that suppress RNA transcription. While the majority of ASOs are well tolerated in…”
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Targeting TLR9 agonists to secondary lymphoid organs induces potent immune responses against HBV infection by Ushach, Irina, Zhu, Ren, Rosler, Elen, Pandey, Rajendra K., De Costa, N. Tilani S., Pourshahian, Soheil, Han, Qinglin, Li, Chris, Beigelman, Leonid, Gryaznov, Sergei M., Yun, Theodore

“…Despite the existence of a prophylactic vaccine against hepatitis B virus (HBV), chronic hepatitis B virus (CHB) infection remains the leading cause of…”
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Notch-Regulated Ankyrin-Repeat Protein Inhibits Notch1 Signaling: Multiple Notch1 Signaling Pathways Involved In T Cell Development by Yun, Theodore J, Bevan, Michael J

“…We have characterized the function of Notch-regulated ankyrin-repeat protein (Nrarp) in mouse cell lines and in hematopoietic stem cells (HSCs). Nrarp…”
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OPG/FDCR-1, a TNF Receptor Family Member, Is Expressed in Lymphoid Cells and Is Up-Regulated by Ligating CD40 by Yun, Theodore J, Chaudhary, Preet M, Shu, Geraldine L, Frazer, J. Kimble, Ewings, Maria K, Schwartz, Stephen M, Pascual, Virginia, Hood, Leroy E, Clark3, Edward A

“…We have cloned a TNFR family member from a follicular dendritic cell (FDC)-like cell line, FDC-1. This molecule, FDC-derived receptor-1 (FDCR-1), is identical…”
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Osteoprotegerin, a Crucial Regulator of Bone Metabolism, Also Regulates B Cell Development and Function by Yun, Theodore J, Tallquist, Michelle D, Aicher, Alexandra, Rafferty, Katherine L, Marshall, Aaron J, Moon, James J, Ewings, Maria K, Mohaupt, Mariette, Herring, Susan W, Clark, Edward A

“…Osteoprotegerin (OPG) is a CD40-regulated gene in B cells and dendritic cells (DCs). We investigated the role of OPG in the immune system by generating…”
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CD150 Association with Either the SH2-Containing Inositol Phosphatase or the SH2-Containing Protein Tyrosine Phosphatase Is Regulated by the Adaptor Protein SH2D1A by Shlapatska, Larysa M, Mikhalap, Svitlana V, Berdova, Anna G, Zelensky, Oleksander M, Yun, Theodore J, Nichols, Kim E, Clark, Edward A, Sidorenko, Svetlana P

“…CD150 (SLAM/IPO-3) is a cell surface receptor that, like the B cell receptor, CD40, and CD95, can transmit positive or negative signals. CD150 can associate…”
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EC144 Is a Potent Inhibitor of the Heat Shock Protein 90 by Shi, Jiandong, Van de Water, Ryan, Hong, Kevin, Lamer, Ryan B, Weichert, Kenneth W, Sandoval, Cristina M, Kasibhatla, Srinivas R, Boehm, Marcus F, Chao, Jianhua, Lundgren, Karen, Timple, Noelito, Lough, Rachel, Ibanez, Gerardo, Boykin, Christina, Burrows, Francis J, Kehry, Marilyn R, Yun, Theodore J, Harning, Erin K, Ambrose, Christine, Thompson, Jeffrey, Bixler, Sarah A, Dunah, Anthone, Snodgrass-Belt, Pamela, Arndt, Joseph, Enyedy, Istvan J, Li, Ping, Hong, Victor S, McKenzie, Andres, Biamonte, Marco A

“…Alkyne 40, 5-(2-amino-4-chloro-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-methylpent-4-yn-2-ol (EC144), is a second…”
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Stimulation of osteoprotegerin production is responsible for osteosclerosis in mice overexpressing TPO by Chagraoui, Hédia, Tulliez, Micheline, Smayra, Tarek, Komura, Emiko, Giraudier, Stéphane, Yun, Theodore, Lassau, Nathalie, Vainchenker, William, Wendling, Françoise

“…Myelofibrosis and osteosclerosis are prominent features arising in mice overexpressing thrombopoietin (TPO). The pivotal role of transforming growth factor β1…”
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Osteoprotegerin and rank ligand expression in prostate cancer by Brown, Julie M, Corey, Eva, Lee, Zandra D, True, Lawrence D, Yun, Theodore J, Tondravi, Mehrdad, Vessella, Robert L

“…Objectives. To investigate the expression of osteoprotegerin (OPG) and RANK ligand (RANKL) in human prostatic tissues. The factors regulating the increased…”
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The Gads (GrpL) Adaptor Protein Regulates T Cell Homeostasis by Yankee, Thomas M, Yun, Theodore J, Draves, Kevin E, Ganesh, Kolumam, Bevan, Michael J, Murali-Krishna, Kaja, Clark, Edward A

“…Little is known about the role of the Gads (GrpL) adaptor protein in mature T cell populations. In this study we show that the effects of Gads deficiency on…”
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Spi-1 and Spi-B control the expression of the Grap2 gene in B cells by Garrett-Sinha, Lee Ann, Hou, Ping, Wang, Duncheng, Grabiner, Brian, Araujo, Elizabeth, Rao, Sridhar, Yun, Theodore J., Clark, Edward A., Simon, M. Celeste, Clark, Marcus R.

“…The Ets family members Spi-1 and Spi-B have been implicated in the regulation of genes important for B cell antigen receptor (BCR) signaling. Mice deficient in…”
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The Goldilocks conditions applied to T cell development by Yun, Theodore J, Bevan, Michael J

“…The newly rearranged T cell receptor on the surface of immature thymocytes must interact with not too much and not too little affinity for self-peptide-MHC…”
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A novel B lymphocyte-associated adaptor protein, Bam32, regulates antigen receptor signaling downstream of phosphatidylinositol 3-kinase by Marshall, A J, Niiro, H, Lerner, C G, Yun, T J, Thomas, S, Disteche, C M, Clark, E A

“…We have identified and characterized a novel src homology 2 (SH2) and pleckstrin homology (PH) domain-containing adaptor protein, designated Bam32 (for B cell…”
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A Complex Major Histocompatibility Complex D Locus Variant Generated by an Unusual Recombination Mechanism in Mice by Yun, Theodore J., Melvold, Roger W., Pease, Larry R.

“…A spontaneous variant of the mouse class I major histocompatibility complex Db gene, designated Dbm28, is characterized. This mutation consists of a cluster of…”
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Minor pocket B influences peptide binding, peptide presentation and alloantigenicity of H-2Kb by Yun, T J, Tallquist, M D, Rohren, E M, Sheil, J M, Pease, L R

“…Microsequence analysis of peptides eluted from the murine class I H-2Kb molecule together with the three-dimensional structure of the molecule co-crystallized…”
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GrpL, a Grb2-related adaptor protein, interacts with SLP-76 to regulate nuclear factor of activated T cell activation by Law, C L, Ewings, M K, Chaudhary, P M, Solow, S A, Yun, T J, Marshall, A J, Hood, L, Clark, E A

“…Propagation of signals from the T cell antigen receptor (TCR) involves a number of adaptor molecules. SH2 domain-containing protein 76 (SLP-76) interacts with…”
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Tumor necrosis factor alone does not explain the lethal effect of lipopolysaccharide by Sánchez-Cantú, L, Rode, H N, Yun, T J, Christou, N V

“…Lethality and tumor necrosis factor production induced by different types of lipopolysaccharide were studied in naive (non-primed) rats during the late phase…”
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Osteoprotegerin Is an αvβ3-induced, NF-κB-dependent Survival Factor for Endothelial Cells by Malyankar, Uriel M., Scatena, Marta, Suchland, Katherine L., Yun, Theodore J., Clark, Edward A., Giachelli, Cecilia M.

“…Osteopontin protects endothelial cells from apoptosis induced by growth factor withdrawal. This interaction is mediated by the αvβ3 integrin and is…”
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