Search Results - "Yun, Nuri"

Co-delivery of curcumin and miRNA-144-3p using heart-targeted extracellular vesicles enhances the therapeutic efficacy for myocardial infarction by Kang, Ji-Young, Kim, Hyoeun, Mun, Dasom, Yun, Nuri, Joung, Boyoung

“…Curcumin exerts therapeutic effects in heart disease, but has limited bioavailability. Extracellular vesicles (EVs) have gained attention as nanovehicles;…”
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Cardiac-specific delivery by cardiac tissue-targeting peptide-expressing exosomes by Kim, Hyoeun, Yun, Nuri, Mun, Dasom, Kang, Ji-Young, Lee, Seung-Hyun, Park, Hyelim, Park, Hyewon, Joung, Boyoung

“…Naturally occurring RNA carriers such as exosomes might be an untapped source of effective delivery vehicles. However, if exosomes are to be exploited for…”
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Calcium chloride enhances the delivery of exosomes by Kim, Hyoeun, Kang, Ji-Young, Mun, Dasom, Yun, Nuri, Joung, Boyoung

“…Exosomes might have an unimproved potential to serve as effective delivery vehicles. However, when exosomes are developed for therapeutic applications, a…”
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Establishment of a human-induced pluripotent stem cell line from a long QT syndrome type 2 patient harboring a KCNH2 mutation by Mun, Dasom, Kang, Ji-Young, Park, Malgeum, Yoo, Gyeongseo, Kim, Hyoeun, Yun, Nuri, Mi Hwang, You, Joung, Boyoung

“…Long QT syndrome type 2 (LQT2) is a heart disorder resulting from a loss-of-function mutation in theKCNH2gene that causes loss of Kv11.1 channel function,…”
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Improved cardiac-specific delivery of RAGE siRNA within small extracellular vesicles engineered to express intense cardiac targeting peptide attenuates myocarditis by Kim, Hyoeun, Mun, Dasom, Kang, Ji-Young, Lee, Seung-Hyun, Yun, Nuri, Joung, Boyoung

“…Small extracellular vesicles (sEVs) are nanometer-sized membranous vesicles secreted by cells, with important roles in physiological and pathological…”
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Generation of a heterozygous TPM1-E192K knock-in human induced pluripotent stem cell line using CRISPR/Cas9 system by Kang, Ji-Young, Mun, Dasom, Chun, Yumin, Kim, Hyoeun, Yun, Nuri, Lee, Seung-Hyun, Joung, Boyoung

“…E192K missense mutation of TPM1 has been found in different types of cardiomyopathies (e.g., hypertrophic cardiomyopathy, dilated cardiomyopathy, and left…”
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Engineered small extracellular vesicle-mediated NOX4 siRNA delivery for targeted therapy of cardiac hypertrophy by Kang, Ji-Young, Mun, Dasom, Chun, Yumin, Park, Da-Seul, Kim, Hyoeun, Yun, Nuri, Joung, Boyoung

“…Small-interfering RNA (siRNA) therapy is considered a powerful therapeutic strategy for treating cardiac hypertrophy, an important risk factor for subsequent…”
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Generation of two PITX2 knock-out human induced pluripotent stem cell lines using CRISPR/Cas9 system by Mun, Dasom, Kang, Ji-Young, Chun, Yumin, Park, Da-Seul, Kim, Hyoeun, Yun, Nuri, Lee, Seung-Hyun, Joung, Boyoung

“…PITX2 is a homeobox gene located in the human 4q25 locus and is commonly associated with atrial fibrillation (AF). Here, we generated two PITX2 knock-out human…”
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RING-finger protein 166 plays a novel pro-apoptotic role in neurotoxin-induced neurodegeneration via ubiquitination of XIAP by Oh, Chang-Ki, Choi, Young Ki, Hwang, Ih-Yeon, Ko, Yeon Uk, Chung, In Kwon, Yun, Nuri, Oh, Young J.

“…The dopaminergic neurotoxin, 6-hydroxydopamine (6-OHDA), has been widely utilized to establish experimental models of Parkinson disease and to reveal the…”
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Generation of three TTN knock-out human induced pluripotent stem cell lines using CRISPR/Cas9 system by Kang, Ji-Young, Mun, Dasom, Chun, Yumin, Park, Da-Seul, Kim, Hyoeun, Yun, Nuri, Lee, Seung-Hyun, Joung, Boyoung

“…TTN mutations are the common genetic cause for various types of cardiomyopathies (e.g., dilated cardiomyopathy, hypertrophic cardiomyopathy, restrictive…”
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Caspase-3-mediated cleavage of PICOT in apoptosis by Yun, Nuri, Kim, Chiho, Cha, Hyeseon, Park, Woo Jin, Shibayama, Hirohiko, Park, Il-Seon, Oh, Young J.

“…► PICOT was specifically cleaved by caspase-3. ► PICOT cleavage was found in prototypic caspase-dependent apoptosis. ► Cleavage sequence in PICOT was mapped at…”
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Gel-based Protease Proteomics for Identifying the Novel Calpain Substrates in Dopaminergic Neuronal Cell by Kim, Chiho, Yun, Nuri, Lee, Young Mook, Jeong, Jae Y., Baek, Jeong Y., Song, Hwa Young, Ju, Chung, Youdim, Moussa B.H., Jin, Byung K., Kim, Won-Ki, Oh, Young J.

“…Calpains are a family of calcium-dependent cysteine proteases that are ubiquitously expressed in mammals and play critical roles in neuronal death by…”
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Mitigation of Blast Effects on Protective Structures by Aluminum Foam Panels by Shim, Changsu, Yun, Nuri, Yu, Robin, Byun, Doyeon

“…Aluminum foams have low density and are attractive materials to mitigate high-speed pressure by blast loads due to high-energy absorption capabilities. In…”
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Nuclear translocation of anamorsin during drug-induced dopaminergic neurodegeneration in culture and in rat brain by Park, Kyung-Ah, Yun, Nuri, Shin, Dong-Ik, Choi, So Yoen, Kim, Hyun, Kim, Won-Ki, Kanakura, Yuzuru, Shibayama, Hirohiko, Oh, Young J.

“…Anamorsin, also called cytokine-induced apoptosis inhibitor 1 (CIAPIN1), was recently identified to confer resistance to apoptosis induced by growth factor…”
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Small extracellular vesicle-mediated CRISPR-Cas9 RNP delivery for cardiac-specific genome editing by Mun, Dasom, Kang, Ji-Young, Kim, Hyoeun, Yun, Nuri, Joung, Boyoung

“…Myocardial infarction (MI) is a major cause of morbidity and mortality worldwide. Although clustered regularly interspaced short palindromic repeats…”
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Serum exosomal long noncoding RNAs as a diagnostic biomarker for atrial fibrillation by Kang, Ji-Young, Mun, Dasom, Kim, Hyoeun, Yun, Nuri, Joung, Boyoung

“…Exosomal long noncoding RNAs (lncRNAs) are known as ideal diagnostic biomarkers of various diseases. However, there are no reports on the use of serum exosomal…”
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Dysregulated autophagy is linked to BAX oligomerization and subsequent cytochrome c release in 6-hydroxydopmaine-treated neuronal cells by Chung, Yuhyun, Kim, Yoonkyung, Yun, Nuri, Oh, Young J.

“…Autophagy and apoptosis are essential physiological pathways that are required to maintain cellular homeostasis. Therefore, it is suggested that dysregulation…”
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A surge of cytosolic calcium dysregulates lysosomal function and impairs autophagy flux during cupric chloride-induced neuronal death by Kim, Yoonkyung, Lee, Yangsin, Choo, Minjung, Yun, Nuri, Cho, Jin Won, Oh, Young J

“…Autophagy is a degradative pathway that plays an important role in maintaining cellular homeostasis. Dysfunction of autophagy is associated with the…”
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Asymmetric dimethylation of AMPKα1 by PRMT6 contributes to the formation of phase-separated puncta by Yoo, Yeon Ju, Cho, Giseong, Kim, Dana, Kim, Yoonkyung, Yun, Nuri, Oh, Young J.

“…AMP-activated protein kinase (AMPK) is a heterotrimeric serine/threonine kinase comprising α, β, and γ subunits. AMPK is involved in intracellular energy…”
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Establishment of two human induced pluripotent stem cell lines from familial long QT syndrome type 1 patients carrying KCNQ1 mutation by Mun, Dasom, Yoo, Gyeongseo, Park, Malgeum, Kang, Ji-Young, Yun, Nuri, Joung, Boyoung

“…Long QT syndrome type 1 (LQT1) is a rare heart disorder caused by a loss-of-function mutation in the KCNQ1 gene that causes loss of Kv7.1 channel function,…”
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