Search Results - "Yun, Maximina H."
-
1
CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle
Published in Nature (21-05-2009)“…The repair of DNA double-strand breaks (DSBs) is tightly regulated during the cell cycle. In G1 phase, the absence of a sister chromatid means that repair of…”
Get full text
Journal Article -
2
Changes in Regenerative Capacity through Lifespan
Published in International journal of molecular sciences (23-10-2015)“…Most organisms experience changes in regenerative abilities through their lifespan. During aging, numerous tissues exhibit a progressive decline in homeostasis…”
Get full text
Journal Article -
3
Conserved and novel functions of programmed cellular senescence during vertebrate development
Published in Development (Cambridge) (01-01-2017)“…Cellular senescence, a form of stable cell cycle arrest that is traditionally associated with tumour suppression, has been recently found to occur during…”
Get full text
Journal Article -
4
Recurrent turnover of senescent cells during regeneration of a complex structure
Published in eLife (05-05-2015)“…Cellular senescence has been recently linked to the promotion of age-related pathologies, including a decline in regenerative capacity. While such capacity…”
Get full text
Journal Article -
5
Regulation of p53 is critical for vertebrate limb regeneration
Published in Proceedings of the National Academy of Sciences - PNAS (22-10-2013)“…Extensive regeneration of the vertebrate body plan is found in salamander and fish species. In these organisms, regeneration takes place through reprogramming…”
Get full text
Journal Article -
6
Salamander Insights Into Ageing and Rejuvenation
Published in Frontiers in cell and developmental biology (07-06-2021)“…Exhibiting extreme regenerative abilities which extend to complex organs and entire limbs, salamanders have long served as research models for understanding…”
Get full text
Journal Article -
7
Standardized gene and genetic nomenclature for the newt Pleurodeles waltl
Published in Developmental dynamics (01-06-2022)“…Key Findings We support the adoption of the axolotl nomenclature guidelines proposed by Nowoshilow et al by the P. waltl community…”
Get full text
Journal Article -
8
A conserved regulatory program initiates lateral plate mesoderm emergence across chordates
Published in Nature communications (26-08-2019)“…Cardiovascular lineages develop together with kidney, smooth muscle, and limb connective tissue progenitors from the lateral plate mesoderm (LPM). How the LPM…”
Get full text
Journal Article -
9
Tig1 regulates proximo-distal identity during salamander limb regeneration
Published in Nature communications (03-03-2022)“…Salamander limb regeneration is an accurate process which gives rise exclusively to the missing structures, irrespective of the amputation level. This suggests…”
Get full text
Journal Article -
10
Publisher Correction: Tig1 regulates proximo-distal identity during salamander limb regeneration
Published in Nature communications (03-08-2022)Get full text
Journal Article -
11
Sustained ERK Activation Underlies Reprogramming in Regeneration-Competent Salamander Cells and Distinguishes Them from Their Mammalian Counterparts
Published in Stem cell reports (08-07-2014)“…In regeneration-competent vertebrates, such as salamanders, regeneration depends on the ability of various differentiated adult cell types to undergo natural…”
Get full text
Journal Article -
12
Macrophages modulate fibrosis during newt lens regeneration
Published in Stem cell research & therapy (14-05-2024)“…Previous studies have suggested that macrophages are present during lens regeneration in newts, but their role in the process is yet to be elucidated. Here we…”
Get full text
Journal Article -
13
Obatoclax Rescues FUS-ALS Phenotypes in iPSC-Derived Neurons by Inducing Autophagy
Published in Cells (Basel, Switzerland) (01-09-2023)“…Aging is associated with the disruption of protein homeostasis and causally contributes to multiple diseases, including amyotrophic lateral sclerosis (ALS)…”
Get full text
Journal Article -
14
Understanding the functions of BRCA1 in the DNA-damage response
Published in Biochemical Society transactions (01-06-2009)“…Inheritance of a mutation in BRCA1 (breast cancer 1 early-onset) results in predisposition to early-onset breast and ovarian cancer. Tumours in these…”
Get more information
Journal Article -
15
Cellular senescence in tissue repair: every cloud has a silver lining
Published in The International journal of developmental biology (2018)“…Cellular senescence, a form of stable cell cycle arrest induced by cellular stress, constitutes a major factor leading to the promotion of pathologies and…”
Get full text
Journal Article -
16
Out with the old, in with the new: senescence in development
Published in Current opinion in cell biology (01-12-2018)“…Cellular senescence is a ubiquitous stress response that restricts the proliferative capacity of cells. During ageing, senescent cells accumulate in various…”
Get full text
Journal Article -
17
Rising from the ashes: cellular senescence in regeneration
Published in Current opinion in genetics & development (01-10-2020)“…Cellular senescence has recently become causally implicated in pathological ageing. Hence, a great deal of research is currently dedicated towards developing…”
Get full text
Journal Article -
18
Senescent cells enhance newt limb regeneration by promoting muscle dedifferentiation
Published in Aging cell (01-06-2023)“…Salamanders are able to regenerate their entire limbs throughout lifespan, through a process that involves significant modulation of cellular plasticity. Limb…”
Get full text
Journal Article -
19
Meeting report: Salamander models in cross‐disciplinary biological research meeting
Published in Developmental dynamics (01-06-2022)“…The third annual meeting on “Salamander Models in Cross‐disciplinary Biological Research” took place online on August 2021, bringing together over 200…”
Get full text
Journal Article -
20
Can laboratory model systems instruct human limb regeneration?
Published in Development (Cambridge) (02-10-2019)“…Regeneration has fascinated scientists since well before the 20th century revolutions in genetics and molecular biology. The field of regenerative biology has…”
Get full text
Journal Article