Search Results - "Yun, Maximina H."

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  1. 1

    CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle by Hiom, Kevin, Yun, Maximina H

    Published in Nature (21-05-2009)
    “…The repair of DNA double-strand breaks (DSBs) is tightly regulated during the cell cycle. In G1 phase, the absence of a sister chromatid means that repair of…”
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  2. 2

    Changes in Regenerative Capacity through Lifespan by Yun, Maximina H

    “…Most organisms experience changes in regenerative abilities through their lifespan. During aging, numerous tissues exhibit a progressive decline in homeostasis…”
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  3. 3

    Conserved and novel functions of programmed cellular senescence during vertebrate development by Davaapil, Hongorzul, Brockes, Jeremy P, Yun, Maximina H

    Published in Development (Cambridge) (01-01-2017)
    “…Cellular senescence, a form of stable cell cycle arrest that is traditionally associated with tumour suppression, has been recently found to occur during…”
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  4. 4

    Recurrent turnover of senescent cells during regeneration of a complex structure by Yun, Maximina H, Davaapil, Hongorzul, Brockes, Jeremy P

    Published in eLife (05-05-2015)
    “…Cellular senescence has been recently linked to the promotion of age-related pathologies, including a decline in regenerative capacity. While such capacity…”
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  5. 5

    Regulation of p53 is critical for vertebrate limb regeneration by Yun, Maximina H., Gates, Phillip B., Brockes, Jeremy P.

    “…Extensive regeneration of the vertebrate body plan is found in salamander and fish species. In these organisms, regeneration takes place through reprogramming…”
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  6. 6

    Salamander Insights Into Ageing and Rejuvenation by Yun, Maximina H.

    “…Exhibiting extreme regenerative abilities which extend to complex organs and entire limbs, salamanders have long served as research models for understanding…”
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  7. 7

    Standardized gene and genetic nomenclature for the newt Pleurodeles waltl by Yun, Maximina H., Hayashi, Toshinori, Simon, Andras

    Published in Developmental dynamics (01-06-2022)
    “…Key Findings We support the adoption of the axolotl nomenclature guidelines proposed by Nowoshilow et al by the P. waltl community…”
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    Tig1 regulates proximo-distal identity during salamander limb regeneration by Oliveira, Catarina R., Knapp, Dunja, Elewa, Ahmed, Gerber, Tobias, Gonzalez Malagon, Sandra G., Gates, Phillip B., Walters, Hannah E., Petzold, Andreas, Arce, Hernan, Cordoba, Rodrigo C., Subramanian, Elaiyaraja, Chara, Osvaldo, Tanaka, Elly M., Simon, András, Yun, Maximina H.

    Published in Nature communications (03-03-2022)
    “…Salamander limb regeneration is an accurate process which gives rise exclusively to the missing structures, irrespective of the amputation level. This suggests…”
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    Sustained ERK Activation Underlies Reprogramming in Regeneration-Competent Salamander Cells and Distinguishes Them from Their Mammalian Counterparts by Yun, Maximina H., Gates, Phillip B., Brockes, Jeremy P.

    Published in Stem cell reports (08-07-2014)
    “…In regeneration-competent vertebrates, such as salamanders, regeneration depends on the ability of various differentiated adult cell types to undergo natural…”
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  12. 12

    Macrophages modulate fibrosis during newt lens regeneration by Tsissios, Georgios, Sallese, Anthony, Perez-Estrada, J Raul, Tangeman, Jared A, Chen, Weihao, Smucker, Byran, Ratvasky, Sophia C, Grajales-Esquivel, Erika, Martinez, Arielle, Visser, Kimberly J, Joven Araus, Alberto, Wang, Hui, Simon, András, Yun, Maximina H, Del Rio-Tsonis, Katia

    Published in Stem cell research & therapy (14-05-2024)
    “…Previous studies have suggested that macrophages are present during lens regeneration in newts, but their role in the process is yet to be elucidated. Here we…”
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  13. 13

    Obatoclax Rescues FUS-ALS Phenotypes in iPSC-Derived Neurons by Inducing Autophagy by Castillo Bautista, Cristina Marisol, Eismann, Kristin, Gentzel, Marc, Pelucchi, Silvia, Mertens, Jerome, Walters, Hannah E, Yun, Maximina H, Sterneckert, Jared

    Published in Cells (Basel, Switzerland) (01-09-2023)
    “…Aging is associated with the disruption of protein homeostasis and causally contributes to multiple diseases, including amyotrophic lateral sclerosis (ALS)…”
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  14. 14

    Understanding the functions of BRCA1 in the DNA-damage response by Yun, Maximina H, Hiom, Kevin

    Published in Biochemical Society transactions (01-06-2009)
    “…Inheritance of a mutation in BRCA1 (breast cancer 1 early-onset) results in predisposition to early-onset breast and ovarian cancer. Tumours in these…”
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  15. 15

    Cellular senescence in tissue repair: every cloud has a silver lining by Yun, Maximina H

    “…Cellular senescence, a form of stable cell cycle arrest induced by cellular stress, constitutes a major factor leading to the promotion of pathologies and…”
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  16. 16

    Out with the old, in with the new: senescence in development by Czarkwiani, Anna, Yun, Maximina H

    Published in Current opinion in cell biology (01-12-2018)
    “…Cellular senescence is a ubiquitous stress response that restricts the proliferative capacity of cells. During ageing, senescent cells accumulate in various…”
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  17. 17

    Rising from the ashes: cellular senescence in regeneration by Walters, Hannah E, Yun, Maximina H

    Published in Current opinion in genetics & development (01-10-2020)
    “…Cellular senescence has recently become causally implicated in pathological ageing. Hence, a great deal of research is currently dedicated towards developing…”
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  18. 18

    Senescent cells enhance newt limb regeneration by promoting muscle dedifferentiation by Walters, Hannah E., Troyanovskiy, Konstantin E., Graf, Alwin M., Yun, Maximina H.

    Published in Aging cell (01-06-2023)
    “…Salamanders are able to regenerate their entire limbs throughout lifespan, through a process that involves significant modulation of cellular plasticity. Limb…”
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  19. 19

    Meeting report: Salamander models in cross‐disciplinary biological research meeting by Masselink, Wouter, Sandoval‐Guzmán, Tatiana, Yun, Maximina H.

    Published in Developmental dynamics (01-06-2022)
    “…The third annual meeting on “Salamander Models in Cross‐disciplinary Biological Research” took place online on August 2021, bringing together over 200…”
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  20. 20

    Can laboratory model systems instruct human limb regeneration? by Cox, Ben D, Yun, Maximina H, Poss, Kenneth D

    Published in Development (Cambridge) (02-10-2019)
    “…Regeneration has fascinated scientists since well before the 20th century revolutions in genetics and molecular biology. The field of regenerative biology has…”
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