Search Results - "Yukihiko ARAMAKI"

Enzymatically polymerised polyphenols prepared from various precursors potentiate antigen-specific immune responses in both mucosal and systemic compartments in mice by Tada, Rui, Ogasawara, Miki, Yamanaka, Daisuke, Sakurai, Yasuhiro, Negishi, Yoichi, Kiyono, Hiroshi, Ohno, Naohito, Kunisawa, Jun, Aramaki, Yukihiko

“…Despite significant modern medicine progress, having an infectious disease is a major risk factor for humans. Mucosal vaccination is now widely considered as…”
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Intranasal Immunization with DOTAP Cationic Liposomes Combined with DC-Cholesterol Induces Potent Antigen-Specific Mucosal and Systemic Immune Responses in Mice by Tada, Rui, Hidaka, Akira, Iwase, Naoko, Takahashi, Saeko, Yamakita, Yuki, Iwata, Tomoko, Muto, Shoko, Sato, Emi, Takayama, Noriko, Honjo, Emi, Kiyono, Hiroshi, Kunisawa, Jun, Aramaki, Yukihiko

“…Despite the progress made by modern medicine, infectious diseases remain one of the most important threats to human health. Vaccination against pathogens is…”
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Intranasal administration of cationic liposomes enhanced granulocyte-macrophage colony-stimulating factor expression and this expression is dispensable for mucosal adjuvant activity by Tada, Rui, Hidaka, Akira, Kiyono, Hiroshi, Kunisawa, Jun, Aramaki, Yukihiko

“…Infectious diseases remain a threat to human life. Vaccination against pathogenic microbes is a primary method of treatment as well as prevention of infectious…”
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Attachment of class B CpG ODN onto DOTAP/DC-chol liposome in nasal vaccine formulations augments antigen-specific immune responses in mice by Tada, Rui, Muto, Shoko, Iwata, Tomoko, Hidaka, Akira, Kiyono, Hiroshi, Kunisawa, Jun, Aramaki, Yukihiko

“…To overcome infectious diseases, the development of mucosal vaccines would be an effective strategy, since mucosal surfaces are the entry site for most…”
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Combination of Bubble Liposomes and High-Intensity Focused Ultrasound (HIFU) Enhanced Antitumor Effect by Tumor Ablation by Hamano, Nobuhito, Negishi, Yoichi, Takatori, Kyohei, Endo-Takahashi, Yoko, Suzuki, Ryo, Maruyama, Kazuo, Niidome, Takuro, Aramaki, Yukihiko

“…Ultrasound (US) is used in the clinical setting not only for diagnosis but also for therapy. As a therapeutic US technique, high-intensity focused ultrasound…”
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Suppression of Skin Lesions by Transdermal Application of CpG-Oligodeoxynucleotides in NC/Nga Mice, a Model of Human Atopic Dermatitis by Inoue, Joe, Aramaki, Yukihiko

“…Atopic dermatitis (AD) is a pruritic inflammatory skin disease characterized by an elevation of the total IgE level in plasma, the infiltration of mast cells…”
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Bubble Liposomes and Ultrasound Promoted Endosomal Escape of TAT-PEG Liposomes as Gene Delivery Carriers by Omata, Daiki, Negishi, Yoichi, Hagiwara, Shoko, Yamamura, Sho, Endo-Takahashi, Yoko, Suzuki, Ryo, Maruyama, Kazuo, Nomizu, Motoyoshi, Aramaki, Yukihiko

“…We have previously developed laminin-derived AG73 peptide-labeled poly­(ethylene glycol)-modified liposomes (AG73-PEG liposomes) for selective cancer gene…”
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Essential Role of Host Double-Stranded DNA Released from Dying Cells by Cationic Liposomes for Mucosal Adjuvanticity by Tada, Rui, Ohshima, Akihiro, Tanazawa, Yuya, Ohmi, Akari, Takahashi, Saeko, Kiyono, Hiroshi, Kunisawa, Jun, Aramaki, Yukihiko, Negishi, Yoichi

“…Infectious disease remains a substantial cause of death. To overcome this issue, mucosal vaccine systems are considered to be a promising strategy. Yet, none…”
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Modification of the C16Y peptide on nanoparticles is an effective approach to target endothelial and cancer cells via the integrin receptor by Hamano, Nobuhito, Negishi, Yoichi, Fujisawa, Azusa, Manandhar, Maya, Sato, Hinako, Katagiri, Fumihiko, Nomizu, Motoyoshi, Aramaki, Yukihiko

“…Liposomes have been explored as potential drug and gene-delivery particles. In recent years, tumor-targeted liposomes have been developed to improve the…”
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Bubble Liposomes and Ultrasound Enhance the Antitumor Effects of AG73 Liposomes Encapsulating Antitumor Agents by Hamano, Nobuhito, Negishi, Yoichi, Omata, Daiki, Takahashi, Yoko, Manandhar, Maya, Suzuki, Ryo, Maruyama, Kazuo, Nomizu, Motoyoshi, Aramaki, Yukihiko

“…Encapsulating anticancer drugs in liposomes improves their therapeutic window by enhancing antitumor efficacy and reducing side effects. To devise more…”
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Cationic liposomes induce apoptosis through p38 MAP kinase–caspase-8–Bid pathway in macrophage-like RAW264.7 cells by Iwaoka, Sayaka, Nakamura, Tomoko, Takano, Shuhei, Tsuchiya, Seishi, Aramaki, Yukihiko

“…We have demonstrated that cationic liposomes composed of stearylamine (SA‐liposomes) induce apoptosis in a variety of cells, but the mechanism responsible for…”
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Endosomal Translocation of CpG-Oligodeoxynucleotides Inhibits DNA-PKcs-Dependent IL-10 Production in Macrophages by Yotsumoto, Satoshi, Saegusa, Kazuharu, Aramaki, Yukihiko

“…Synthetic oligodeoxynucleotides containing unmethylated CpG motifs (CpG-ODNs) function as powerful immune adjuvants by activating macrophages, dendritic cells,…”
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Physicochemical properties of liposomes affecting apoptosis induced by cationic liposomes in macrophages by TAKANO, Shuhei, ARAMAKI, Yukihiko, TSUCHIYA, Seishi

“…Cationic liposomes are expected to be useful as nonviral vectors for gene delivery. Cationic liposomes showed cytotoxicity, and we proposed that the…”
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Involvement of Ca2+ and ATP in Enhanced Gene Delivery by Bubble Liposomes and Ultrasound Exposure by Omata, Daiki, Negishi, Yoichi, Yamamura, Sho, Hagiwara, Shoko, Endo-Takahashi, Yoko, Suzuki, Ryo, Maruyama, Kazuo, Nomizu, Motoyoshi, Aramaki, Yukihiko

“…Recently, we reported the accelerated gene transfection efficiency of laminin-derived AG73-peptide-labeled polyethylene glycol-modified liposomes (AG73-PEG…”
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Preparation and Characterization of Laminin-Derived Peptide AG73-Coated Liposomes as a Selective Gene Delivery Tool by Negishi, Yoichi, Omata, Daiki, Iijima, Hiroshi, Hamano, Nobuhito, Endo-Takahashi, Yoko, Nomizu, Motoyoshi, Aramaki, Yukihiko

“…Targeted gene delivery to cancer cells is considered as a promising strategy for cancer therapy. Since, several targeting ligands have been studied for cancer…”
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CXCL17 Expression by Tumor Cells Recruits CD11b+Gr1highF4/80− Cells and Promotes Tumor Progression by Matsui, Aya, Yokoo, Hideaki, Negishi, Yoichi, Endo-Takahashi, Yoko, Chun, Nicole A. L., Kadouchi, Ichiro, Suzuki, Ryo, Maruyama, Kazuo, Aramaki, Yukihiko, Semba, Kentaro, Kobayashi, Eiji, Takahashi, Masafumi, Murakami, Takashi

“…Background Chemokines are involved in multiple aspects of pathogenesis and cellular trafficking in tumorigenesis. In this study, we report that the latest…”
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Induction of apoptosis in macrophages by cationic liposomes by Aramaki, Yukihiko, Takano, Shuhei, Tsuchiya, Seishi

“…The effects of liposomes on apoptosis in macrophages were evaluated from DNA content and DNA fragmentation. Cationic liposomes composed of different kinds of…”
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Phosphatidylserine-Specific Receptor Contributes to TGF-β Production in Macrophages through a MAP Kinase, ERK by Otsuka, Masaki, Goto, Kentaro, Tsuchiya, Seishi, Aramaki, Yukihiko

“…We explored the involvement of the phosphatidylserine (PS)-receptor in the production of TGF-β by macrophages treated with PS-liposomes. The binding of…”
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Characteristics of Gastrointestinal Absorption of DX-9065a, a New Synthetic Anticoagulant by Fujii, Yoshimine, Takahashi, Masayuki, Morita, Hiromi, Kikuchi, Hiroshi, Aramaki, Yukihiko, Amidon, Gordon L.

“…DX-9065a, a newly synthesized anticoagulant that selectively inhibits factor Xa, is a zwitterion and has characteristics of high water solubility and low…”
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Induction of cancer cell-specific apoptosis by folate-labeled cationic liposomes by Yoshida, Tomomi, Oide, Naoko, Sakamoto, Takatoshi, Yotsumoto, Satoshi, Negishi, Yoichi, Tsuchiya, Seishi, Aramaki, Yukihiko

“…We have previously reported that cationic liposomes themselves can induce apoptosis in macrophages and lymphocytes. In this paper, we attempted the cancer…”
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