Search Results - "Yukawa, E"

Effect of CYP2C19 genetic polymorphism on pharmacokinetics of phenytoin and phenobarbital in Japanese epileptic patients using Non-linear Mixed Effects Model approach by Yukawa, E., Mamiya, K.

“…Summary Objective:  To clarify the effect of genetic polymorphism of CYP2C19 on pharmacokinetics of phenytoin and phenobarbital using a Non‐linear Mixed…”
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Population pharmacokinetics of phenobarbital by mixed effect modelling using routine clinical pharmacokinetic data in Japanese neonates and infants: an update by Yukawa, M., Yukawa, E., Suematsu, F., Takiguchi, T., Ikeda, H., Aki, H., Mimemoto, M.

“…Summary What is known and objective:  Optimal use of phenobarbital in the neonatal population requires information regarding the drug’s pharmacokinetics and…”
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Effect of obesity on serum amiodarone concentration in Japanese patients: population pharmacokinetic investigation by multiple trough screen analysis by Fukuchi, H., Nakashima, M., Araki, R., Komiya, N., Hayano, M., Yano, K., Sasaki, H., Yukawa, E.

“…Summary Objective:  To evaluate the influence of obesity on pharmacokinetics of amiodarone (AMD) using Non‐Linear Mixed Effects Modelling (nonmem) in Japanese…”
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Population pharmacokinetic investigation of low-dose methotrexate in rheumatoid arthritics Japanese patients by Yukawa, E ., Mori, S., Ueda, K., Nakada, Y.

“…Summary Objective:  To estimate the population pharmacokinetics of low‐dose methotrexate (MTX) in Japanese patients using nonmem, a computer program designed…”
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The effects of genetic polymorphisms of CYP2C9 and CYP2C19 on phenytoin metabolism in Japanese adult patients with epilepsy : Studies in stereoselective hydroxylation and population pharmacokinetics by MAMIYA, K, IEIRI, I, SHIMAMOTO, J, YUKAWA, E, IMAI, J, NINOMIYA, H, YAMADA, H, OTSUBO, K, HIGUCHI, S, TASHIRO, N

“…The aim of this study was to clarify the effects of genetic polymorphisms of cytochrome P450 (CYP) 2C9 and 2C19 on the metabolism of phenytoin (PHT). In…”
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Population pharmacokinetic investigation of digoxin in Japanese neonates by Yukawa, E., Akiyama, K., Suematsu, F., Yukawa, M., Minemoto, M.

“…Summary Objective:  To establish the role of patient characteristics in estimating doses of digoxin for neonates using routine therapeutic drug monitoring…”
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Population-based investigations of drug relative clearance using nonlinear mixed-effect modelling from information generated during the routine clinical care of patients by YUKAWA, E

“…Interpatient variability in drug disposition and response is a therapeutic premise, and thus evaluation and management of such variability are the basis for…”
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Population pharmacokinetic investigation of phenobarbital by mixed effect modelling using routine clinical pharmacokinetic data in Japanese neonates and infants by Yukawa, E., Suematsu, F., Yukawa, M., Minemoto, M.

“…Summary The population pharmacokinetics of phenobarbital was evaluated using 69 serum concentration measurements obtained from the routine phenobarbital…”
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Dosing time dependency of doxorubicin-induced cardiotoxicity and bone marrow toxicity in rats by To, Hideto, Ohdo, Shigehiro, Shin, Mikiko, Uchimaru, Hiroki, Yukawa, Eiji, Higuchi, Shun, Fujimura, Akio, Kobayashi, Eiji

“…Cardiac toxicity caused by doxorubicin (adriamycin) is a serious dose‐limiting factor in the clinical situation. However, the influence of doxorubicin dosing…”
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Population pharmacokinetics of theophylline in very premature Japanese infants with apnoea by Fukuda, T., Yukawa, E., Kondo, G., Maeda, T., Shin-o, T., Kondo, Y., Imamura, T., Irikura, M., Irie, Tetsumi

“…Summary Objective:  To estimate the population pharmacokinetics of theophylline in very premature infants using the non‐linear mixed effects modelling. Method:…”
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CYP2C19 polymorphism effect on phenobarbitone : Pharmacokineties in Japanese patients with epilepsy : analysis by population pharmacokinetics by MAMIYA, K, HADAMA, A, YUKAWA, E, IEIRI, I, OTSUBO, K, NINOMIYA, H, TASHIRO, N, HIGUCHI, S

“…Objective: The aim of this study was to clarify the effect of genetic polymorphisms of CYP2C19 on the pharmacokinetics of phenobarbitone (PB) using a nonlinear…”
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Pharmacoepidemiologic investigation of a clonazepam-valproic acid interaction by mixed effect modeling using routine clinical pharmacokinetic data in Japanese patients by Yukawa, E., Nonaka, T., Yukawa, M., Higuchi, S., Kuroda, T., Goto, Y.

“…Summary Non‐linear Mixed Effects Modeling (NONMEM) was used to estimate the effects of clonazepam–valproic acid interaction on clearance values using 576 serum…”
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New and simple method for estimating metildigoxin dosing regimens by multiple trough screen analysis by Yukawa, E

“…The pharmacokinetics of digitalis glycosides were studied using routine therapeutic drug monitoring data to evaluate the role of patient characteristics for…”
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Population pharmacokinetic investigation of disopyramide by mixed effect modelling using routine clinical pharmacokinetic data in Japanese patients by Yukawa, E., Orio, K., Yukawa, M., Terao, K., Kinoshita, H.

“…Summary Objective:  To estimate the population pharmacokinetic parameters of disopyramide using non‐linear mixed effects modelling. Method:  A total of 148…”
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Population pharmacokinetics of Digoxin in Japanese patients : A 2-compartment pharmacokinetic model by YUKAWA, Eiji, SUEMATU, Fumihiro, YUKAWA, Miho, MINEMOTO, Masao, OHDO, Shigehiro, HIGUCHI, Shun, GOTO, Yoshinobu, AOYAMA, Toshinobu

“…To clarify the observed variability of digoxin disposition by performing a population pharmacokinetic analysis in a Japanese population. Retrospective analysis…”
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Pharmacokinetic and Pharmacodynamic Analysis of Subcutaneous Recombinant Human Granulocyte Colony Stimulating Factor (Lenograstim) Administration by Hayashi, Naoto, Kinoshita, Haruki, Yukawa, Eiji, Higuchi, Shun

“…A total of 72 adult healthy volunteers were administered 1 μg/kg of rhG‐CSF. There was no correlation between Cmax and an increase in peripheral neutrophil…”
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Population pharmacokinetics of haloperidol using Routine clinical pharmacokinetic data in Japanese patients by YUKAWA, Eiji, HOKAZONO, Tsuyoshi, YUKAWA, Miho, ICHIMARU, Ritsuko, MAKI, Takako, MATSUNAGA, Kanemitsu, OHDO, Shigehiro, ANAI, Motoaki, HIGUCHI, Shun, GOTO, Yoshinobu

“…To clarify the observed variability of haloperidol disposition in patients with psychiatric disorders. Retrospective population pharmacokinetic study. 218…”
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Effect of Dosing Schedule on Pharmacokinetics of Alpha Interferon and Anti-Alpha Interferon Neutralizing Antibody in Mice by WANG, De-Sheng, OHDO, Shigehiro, KOYANAGI, Satoru, TAKANE, Hiroshi, ARAMAKI, Hironori, YUKAWA, Eiji, HIGUCHI, Shun

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Population-based investigation of relative clearance of digoxin in Japanese neonates and infants by multiple-trough screen analysis by SUEMATSU, Fumihiro, YUKAWA, Eiji, YUKAWA, Miho, MINEMOTO, Masao, OHDO, Shigehiro, HIGUCHI, Shun, GOTO, Yoshinobu

“…The steady-state concentrations of digoxin at trough levels were studied to establish the role of patient characteristics in estimating doses for digoxin using…”
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Detection of a drug-drug interaction on population-based phenobarbitone clearance using nonlinear mixed-effects modeling by YUKAWA, E, TO, H, OHDO, S, HIGUCHI, S, AOYAMA, T

“…Nonlinear mixed-effects modeling (NONMEM) was used to estimate the effects of drug drug interaction on phenobarbitone clearance values, using 648 serum levels…”
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