Properties of Achromobacter xylosoxidans highly resistant to aminoglycoside antibiotics

We herein discovered a highly resistant clinical isolate of Pseudomonas aeruginosa with MICs to amikacin, gentamicin, and arbekacin of 128 μg/mL or higher in a drug sensitivity survey of 92 strains isolated from the specimens of Yoka hospital patients between January 2009 and October 2010, and Achro...

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Bibliographic Details
Published in:	Japanese journal of antibiotics Vol. 69; no. 2; p. 113
Main Authors:	Nakamoto, Sachiko, Goda, Natsumi, Hayabuchi, Tatsuya, Tamaki, Hiroo, Ishida, Ayami, Suzuki, Ayaka, Nakano, Kaori, Yui, Shoko, Katsumata, Yuto, Yamagami, Yuki, Burioka, Naoto, Chikumi, Hiroki, Shimizu, Eiji
Format:	Journal Article
Language:	English
Published:	Japan 25-04-2016
Subjects:	Achromobacter denitrificans - drug effects Aminoglycosides - pharmacology Anti-Bacterial Agents - pharmacology Drug Resistance, Bacterial Microbial Sensitivity Tests
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Summary:	We herein discovered a highly resistant clinical isolate of Pseudomonas aeruginosa with MICs to amikacin, gentamicin, and arbekacin of 128 μg/mL or higher in a drug sensitivity survey of 92 strains isolated from the specimens of Yoka hospital patients between January 2009 and October 2010, and Achromobacter xylosoxidans was separated from this P. aeruginosa isolate. The sensitivity of this bacterium to 29 antibiotics was investigated. The MICs of this A. xylosoxidans strain to 9 aminoglycoside antibiotics were: amikacin, gentamicin, arbekacin, streptomycin, kanamycin, neomycin, and spectinomycin, 1,024 μg/mL or ≥ 1,024 μg/mL; netilmicin, 512 μg/mL; and tobramycin, 256 μg/mL. This strain was also resistant to dibekacin. This aminoglycoside antibiotic resistant phenotype is very rare, and we are the first report the emergence of A. xylosoxidans with this characteristic.
ISSN:	0368-2781
DOI:	10.11553/antibiotics.69.2_113