Search Results - "Yui, Mary A."

A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment by Ng, Kenneth Kh, Yui, Mary A, Mehta, Arnav, Siu, Sharmayne, Irwin, Blythe, Pease, Shirley, Hirose, Satoshi, Elowitz, Michael B, Rothenberg, Ellen V, Kueh, Hao Yuan

“…Cell fate decisions occur through the switch-like, irreversible activation of fate-specifying genes. These activation events are often assumed to be tightly…”
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Multi-scale Dynamical Modeling of T Cell Development from an Early Thymic Progenitor State to Lineage Commitment by Olariu, Victor, Yui, Mary A., Krupinski, Pawel, Zhou, Wen, Deichmann, Julia, Andersson, Emil, Rothenberg, Ellen V., Peterson, Carsten

“…Intrathymic development of committed progenitor (pro)-T cells from multipotent hematopoietic precursors offers an opportunity to dissect the molecular…”
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Developmental gene networks: a triathlon on the course to T cell identity by Yui, Mary A., Rothenberg, Ellen V.

“…Key Points T cell development depends on the regulated progression of progenitor cells through three major phases that are associated with distinct…”
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gene regulatory network armature for T lymphocyte specification by Georgescu, Constantin, Longabaugh, William J.R, Scripture-Adams, Deirdre D, David-Fung, Elizabeth-Sharon, Yui, Mary A, Zarnegar, Mark A, Bolouri, Hamid, Rothenberg, Ellen V

“…Choice of a T lymphoid fate by hematopoietic progenitor cells depends on sustained Notch-Delta signaling combined with tightly regulated activities of multiple…”
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Notch/Delta Signaling Constrains Reengineering of Pro-T Cells by PU.1 by Franco, Christopher B., Scripture-Adams, Deirdre D., Proekt, Irina, Taghon, Tom, Weiss, Angela H., Yui, Mary A., Adams, Stephanie L., Diamond, Rochelle A., Rothenberg, Ellen V.

“…PU.1 is essential for early stages of mouse T cell development but antagonizes it if expressed constitutively. Two separable mechanisms are involved:…”
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Launching the T-cell-lineage developmental programme by Rothenberg, Ellen V, Moore, Jonathan E, Yui, Mary A

“…Key Points The early, T-cell receptor (TCR)-independent stages of T-cell development are summarized in this Review. The process of specification, through which…”
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Fine-scale staging of T cell lineage commitment in adult mouse thymus by Yui, Mary A, Feng, Ni, Rothenberg, Ellen V

“…T cell development is marked by the loss of alternative lineage choices accompanying specification and commitment to the T cell lineage. Commitment occurs…”
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Bcl11b sets pro-T cell fate by site-specific cofactor recruitment and by repressing Id2 and Zbtb16 by Hosokawa, Hiroyuki, Romero-Wolf, Maile, Yui, Mary A., Ungerbäck, Jonas, Quiloan, Maria L. G., Matsumoto, Masaki, Nakayama, Keiichi I., Tanaka, Tomoaki, Rothenberg, Ellen V.

“…Multipotent progenitor cells confirm their T cell–lineage identity in the CD4 – CD8 – double-negative (DN) pro-T cell DN2 stages, when expression of the…”
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Asynchronous combinatorial action of four regulatory factors activates Bcl11b for T cell commitment by Kueh, Hao Yuan, Yui, Mary A, Ng, Kenneth K H, Pease, Shirley S, Zhang, Jingli A, Damle, Sagar S, Freedman, George, Siu, Sharmayne, Bernstein, Irwin D, Elowitz, Michael B, Rothenberg, Ellen V

“…Kueh, Rothenberg and colleagues describe distinct, asynchronous and stage-specific mechanisms of T cell commitment mediated by the transcription factors Notch,…”
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Mast cell lineage diversion of T lineage precursors by the essential T cell transcription factor GATA-3 by Rothenberg, Ellen V, Taghon, Tom, Yui, Mary A

“…GATA-3 is essential for T cell development from the earliest stages. However, abundant GATA-3 can drive T lineage precursors to a non-T cell fate, depending on…”
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Single-Cell Analysis Reveals Regulatory Gene Expression Dynamics Leading to Lineage Commitment in Early T Cell Development by Zhou, Wen, Yui, Mary A, Williams, Brian A, Yun, Jina, Wold, Barbara J, Cai, Long, Rothenberg, Ellen V

“…Intrathymic T cell development converts multipotent precursors to committed pro-T cells, silencing progenitor genes while inducing T cell genes, but the…”
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Deficiency of Nuclear Factor-κB c-Rel Accelerates the Development of Autoimmune Diabetes in NOD Mice by Ramakrishnan, Parameswaran, Yui, Mary A, Tomalka, Jeffrey A, Majumdar, Devdoot, Parameswaran, Reshmi, Baltimore, David

“…The nuclear factor-κB protein c-Rel plays a critical role in controlling autoimmunity. c-Rel-deficient mice are resistant to streptozotocin-induced diabetes, a…”
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Hematopoiesis and T-cell specification as a model developmental system by Rothenberg, Ellen V., Kueh, Hao Yuan, Yui, Mary A., Zhang, Jingli A.

“…Summary The pathway to generate T cells from hematopoietic stem cells guides progenitors through a succession of fate choices while balancing differentiation…”
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Therapeutic targeting of the E3 ubiquitin ligase SKP2 in T-ALL by Rodriguez, Sonia, Abundis, Christina, Boccalatte, Francesco, Mehrotra, Purvi, Chiang, Mark Y., Yui, Mary A., Wang, Lin, Zhang, Huajia, Zollman, Amy, Bonfim-Silva, Ricardo, Kloetgen, Andreas, Palmer, Joycelynne, Sandusky, George, Wunderlich, Mark, Kaplan, Mark H., Mulloy, James C., Marcucci, Guido, Aifantis, Iannis, Cardoso, Angelo A., Carlesso, Nadia

“…Timed degradation of the cyclin-dependent kinase inhibitor p27 Kip1 by the E3 ubiquitin ligase F-box protein SKP2 is critical for T-cell progression into cell…”
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Transcription factor expression dynamics of early T-lymphocyte specification and commitment by David-Fung, Elizabeth-Sharon, Butler, Robert, Buzi, Gentian, Yui, Mary A., Diamond, Rochelle A., Anderson, Michele K., Rowen, Lee, Rothenberg, Ellen V.

“…Mammalian T lymphocytes are a prototype for development from adult pluripotent stem cells. While T-cell specification is driven by Notch signaling, T-lineage…”
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Lineage divergence at the first TCR-dependent checkpoint: preferential γδ and impaired αβ T cell development in nonobese diabetic mice by Feng, Ni, Vegh, Patricia, Rothenberg, Ellen V, Yui, Mary A

“…The first TCR-dependent checkpoint in the thymus determines αβ versus γδ T lineage fate and sets the stage for later T cell differentiation decisions. We had…”
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Lineage Divergence at the First TCR-Dependent Checkpoint: Preferential gamma delta and Impaired alpha beta T Cell Development in Nonobese Diabetic Mice by Feng, Ni, Vegh, Patricia, Rothenberg, Ellen V, Yui, Mary A

“…The first TCR-dependent checkpoint in the thymus determines alpha beta versus gamma delta T lineage fate and sets the stage for later T cell differentiation…”
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Loss of T cell progenitor checkpoint control underlies leukemia initiation in Rag1-deficient nonobese diabetic mice by Yui, Mary A, Feng, Ni, Zhang, Jingli A, Liaw, Chen Yee, Rothenberg, Ellen V, Longmate, Jeffrey A

“…NOD mice exhibit major defects in the earliest stages of T cell development in the thymus. Genome-wide genetic and transcriptome analyses were used to…”
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Progression of regulatory gene expression states in fetal and adult pro-T-cell development by David-Fung, Elizabeth-Sharon, Yui, Mary A., Morales, Marissa, Wang, Hua, Taghon, Tom, Diamond, Rochelle A., Rothenberg, Ellen V.

“…Precursors entering the T‐cell developmental pathway traverse a progression of states characterized by distinctive patterns of gene expression. Of particular…”
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Transcriptional establishment of cell-type identity: dynamics and causal mechanisms of T-cell lineage commitment by Rothenberg, Ellen V, Champhekar, Ameya, Damle, Sagar, Del Real, Marissa Morales, Kueh, Hao Yuan, Li, Long, Yui, Mary A

“…Precursor cell entry into the T-cell developmental pathway can be divided into two phases by the closure of T-lineage commitment. As cells decide against the…”
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