Histometric study of socket healing after tooth extraction in rats treated with diclofenac

The purpose of the present study was to investigate if diclofenac administration interferes with the time course of alveolar wound healing in rats. Forty-two Wistar rats were used, 21 rats received 10 mg/kg/day of diclofenac one day before and 4 days after extraction of the right maxillary incisors...

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Bibliographic Details
Published in:	Brazilian dental journal Vol. 13; no. 2; pp. 92 - 96
Main Authors:	Yugoshi, Luciana Ibara, Sala, Miguel Angel, Brentegani, Luiz Guilherme, Lamano Carvalho, Teresa Lúcia
Format:	Journal Article
Language:	English
Published:	Brazil Fundação Odontológica de Ribeirão Preto 2002
Subjects:	Alveolar Process - drug effects Alveolar Process - pathology Animals Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Blood Coagulation - drug effects Capillaries - drug effects Capillaries - pathology Connective Tissue - drug effects Connective Tissue - pathology Dentistry diclofenac Diclofenac - administration & dosage Diclofenac - therapeutic use Fibroblasts - drug effects Fibroblasts - pathology Granulation Tissue - drug effects Granulation Tissue - pathology Injections, Intraperitoneal Male Osteogenesis - drug effects Rats Rats, Wistar socket healing Statistics, Nonparametric Time Factors Tooth Extraction Tooth Socket - drug effects Tooth Socket - pathology Wound Healing - drug effects
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Summary:	The purpose of the present study was to investigate if diclofenac administration interferes with the time course of alveolar wound healing in rats. Forty-two Wistar rats were used, 21 rats received 10 mg/kg/day of diclofenac one day before and 4 days after extraction of the right maxillary incisors and 21 rats received saline. The animals were sacrificed 7, 14 and 21 days after tooth extraction. Progressive new bone formation and a decrease in the volume fraction of blood clot and connective tissue from 1 to 3 weeks after tooth extraction was quantified using the histometric point-counting method. Diclofenac treatment caused a significant delay in new bone formation in association with an impairment of blood clot remission/organization.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0103-6440 0103-6440
DOI:	10.1590/S0103-64402002000200003