Search Results - "Yugo, Kai"

DNase II activated by the mitochondrial apoptotic pathway regulates RIP1-dependent non-apoptotic hepatocyte death via the TLR9/IFN-β signaling pathway by Saito, Yoshinobu, Hikita, Hayato, Nozaki, Yasutoshi, Kai, Yugo, Makino, Yuki, Nakabori, Tasuku, Tanaka, Satoshi, Yamada, Ryoko, Shigekawa, Minoru, Kodama, Takahiro, Sakamori, Ryotaro, Tatsumi, Tomohide, Takehara, Tetsuo

“…Cell death, including apoptotic and non-apoptotic cell death, is frequently observed in liver disease. Upon activation of the mitochondrial apoptotic pathway,…”
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Clinical validation of the suppressive impact of letrozole on liver fibrosis in patients with breast cancer undergoing continuous letrozole administration: A retrospective study by Ohkawa, Kazuyoshi, Nakabori, Tasuku, Mukai, Kaori, Kozumi, Kazuhiro, Urabe, Makiko, Kai, Yugo, Takada, Ryoji, Ikezawa, Kenji, Yamaguchi, Yuko, Nagao, Takuya, Enomoto, Hatsune, Tachiki, Hidehisa, Higuchi, Ayako, Watanabe, Noriyuki, Nakayama, Takahiro

“…Treatment strategies for preventing liver fibrosis have not yet been established. Letrozole, widely used for breast cancer, has recently been reported to…”
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Hepatitis C virus infection suppresses hepatitis B virus replication via the RIG-I-like helicase pathway by Murai, Kazuhiro, Hikita, Hayato, Kai, Yugo, Kondo, Yasuteru, Fukuoka, Makoto, Fukutomi, Keisuke, Doi, Akira, Yamai, Takuo, Nakabori, Tasuku, Fukuda, Ryo, Takahashi, Takeshi, Miyakawa, Kei, Suemizu, Hiroshi, Ryo, Akihide, Yamada, Ryoko, Kodama, Takahiro, Sakamori, Ryotaro, Tatsumi, Tomohide, Takehara, Tetsuo

“…Mechanisms of hepatitis B virus (HBV) reactivation after hepatitis C virus (HCV) elimination by direct-acting antiviral (DAA) treatment in HBV/HCV-co-infected…”
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Mcl-1 expression is a predictive marker of response to gemcitabine plus nab-paclitaxel for metastatic pancreatic cancer by Urabe, Makiko, Ikezawa, Kenji, Seiki, Yusuke, Watsuji, Ko, Kawamoto, Yasuharu, Hirao, Takeru, Kai, Yugo, Takada, Ryoji, Yamai, Takuo, Mukai, Kaori, Nakabori, Tasuku, Uehara, Hiroyuki, Nagata, Shigenori, Ohkawa, Kazuyoshi

“…Antiapoptotic protein, including Mcl-1, expression is frequently observed in pancreatic cancer. Gemcitabine plus nabpaclitaxel (GnP) is the standard…”
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Clinical significance of germline breast cancer susceptibility gene (gBRCA) testing and olaparib as maintenance therapy for patients with pancreatic cancer by Kawamoto, Yasuharu, Yamai, Takuo, Ikezawa, Kenji, Seiki, Yusuke, Watsuji, Ko, Hirao, Takeru, Urabe, Makiko, Kai, Yugo, Takada, Ryoji, Mukai, Kaori, Nakabori, Tasuku, Uehara, Hiroyuki, Inoue, Tazuko, Fujisawa, Fumie, Ohkawa, Kazuyoshi

“…Germline breast cancer susceptibility gene (gBRCA) mutation in patients with pancreatic cancer (PC) is not common in clinical practice. Therefore, factors that…”
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Early detection of venous thromboembolism after the initiation of chemotherapy predicts a poor prognosis in patients with unresectable metastatic pancreatic cancer who underwent first-line chemotherapy with gemcitabine plus nab-paclitaxel by Yamai, Takuo, Ikezawa, Kenji, Hiraga, Erika, Kawamoto, Yasuharu, Hirao, Takeru, Higashi, Sena, Daiku, Kazuma, Maeda, Shingo, Abe, Yutaro, Urabe, Makiko, Kai, Yugo, Takada, Ryoji, Nakabori, Tasuku, Fukutake, Nobuyasu, Uehara, Hiroyuki, Fujita, Masashi, Ohkawa, Kazuyoshi

“…Pancreatic cancer is associated with a high thromboembolism risk. We investigated the significance of early venous thromboembolism (VTE) detection in patients…”
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The Survival Benefit of Chemoradiotherapy following Induction Chemotherapy with Gemcitabine Plus Nab-Paclitaxel for Unresectable Locally Advanced Pancreatic Cancer by Takada, Ryoji, Ikezawa, Kenji, Daiku, Kazuma, Maeda, Shingo, Abe, Yutaro, Urabe, Makiko, Kai, Yugo, Yamai, Takuo, Fukutake, Nobuyasu, Nakabori, Tasuku, Uehara, Hiroyuki, Ashida, Reiko, Akita, Hirofumi, Takahashi, Hidenori, Teshima, Teruki, Ohkawa, Kazuyoshi

“…An optimal therapeutic strategy for unresectable locally advanced pancreatic cancer (UR-LAPC) has not been established. This study investigated the therapeutic…”
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Parallel administration of nanoliposomal irinotecan and levo-leucovorin for pancreatic cancer by Takada, Ryoji, Ikezawa, Kenji, Yamai, Takuo, Watsuji, Ko, Seiki, Yusuke, Kawamoto, Yasuharu, Hirao, Takeru, Higashi, Sena, Urabe, Makiko, Kai, Yugo, Nakabori, Tasuku, Uehara, Hiroyuki, Kotani, Michiyo, Yagi, Toshinari, Kimura, Miho, Nozaki, Keisuke, Takagi, Mari, Ohkawa, Kazuyoshi

“…Nanoliposomal irinotecan (nal-IRI) plus 5-fluorouracil (5-FU)/levo-leucovorin (Levo-LV) was approved for unresectable pancreatic cancer (UR-PC) in March 2020…”
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Combinations of two drugs among NS3/4A inhibitors, NS5B inhibitors and non-selective antiviral agents are effective for hepatitis C virus with NS5A-P32 deletion in humanized-liver mice by Doi, Akira, Hikita, Hayato, Kai, Yugo, Tahata, Yuki, Saito, Yoshinobu, Nakabori, Tasuku, Yamada, Ryoko, Kodama, Takahiro, Sakamori, Ryotaro, Murayama, Asako, Nitta, Sayuri, Asahina, Yasuhiro, Suemizu, Hiroshi, Tatsumi, Tomohide, Kato, Takanobu, Takehara, Tetsuo

“…Background The emergence of a deletion mutant at hepatitis C virus (HCV) NS5A-P32 (P32del) has recently been reported in a subset of chronic hepatitis C…”
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Hepatitis C virus enhances Rubicon expression, leading to autophagy inhibition and intracellular innate immune activation by Shiode, Yuto, Hikita, Hayato, Tanaka, Satoshi, Shirai, Kumiko, Doi, Akira, Sakane, Sadatsugu, Kai, Yugo, Nakabori, Tasuku, Yamada, Ryoko, Kodama, Takahiro, Narumi, Ryohei, Sakamori, Ryotaro, Eguchi, Hidetoshi, Tomonaga, Takeshi, Tatsumi, Tomohide, Takehara, Tetsuo

“…Autophagy, a degradation system, works to maintain cellular homeostasis. However, as the impact of Hepatitis C virus (HCV) infection on hepatocyte autophagy…”
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A case of gallbladder metastasis from nasal mucosal melanoma with noteworthy endoscopic ultrasonography findings by Kai, Yugo, Ikezawa, Kenji, Nagata, Shigenori, Wada, Hiroshi, Isei, Taiki, Ohkawa, Kazuyoshi

“…See PDF.] a Transabdominal B-mode ultrasonography (US) showed a 22 × 12-mm polypoid lesion. b Transabdominal color Doppler US revealed a spotty flow signal in…”
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Nonstructural protein 5A/P32 deletion after failure of ledipasvir/sofosbuvir in hepatitis C virus genotype 1b infection by Doi, Akira, Hikita, Hayato, Sakamori, Ryotaro, Tahata, Yuki, Kai, Yugo, Yamada, Ryoko, Yakushijin, Takayuki, Mita, Eiji, Ohkawa, Kazuyoshi, Imai, Yasuharu, Furuta, Kunimaro, Kodama, Takahiro, Tatsumi, Tomohide, Takehara, Tetsuo

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Utility of Comprehensive Genomic Profiling Tests for Patients with Incurable Pancreatic Cancer in Clinical Practice by Yamai, Takuo, Ikezawa, Kenji, Sugimoto, Naotoshi, Urabe, Makiko, Kai, Yugo, Takada, Ryoji, Nakabori, Tasuku, Uehara, Hiroyuki, Kawamura, Takahisa, Kunimasa, Kei, Yamamoto, Sachiko, Wakamatsu, Toru, Hayashi, Takuji, Kukita, Yoji, Fujisawa, Fumie, Inoue, Tazuko, Yamaguchi, Yuko, Yamasaki, Tomoyuki, Honma, Keiichiro, Ohkawa, Kazuyoshi

“…Although comprehensive genomic profiling (CGP) tests have been covered under the Japanese national health insurance program since 2018, the utility and issues…”
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Pre-existing minor variants with NS5A L31M/V-Y93H double substitution are closely linked to virologic failure with asunaprevir plus daclatasvir treatment for genotype 1b hepatitis C virus infection by Morishita, Naoki, Sakamori, Ryotaro, Yamada, Tomomi, Kai, Yugo, Tahata, Yuki, Urabe, Ayako, Yamada, Ryoko, Kodama, Takahiro, Hikita, Hayato, Doi, Yoshinori, Tamura, Shinji, Hagiwara, Hideki, Imai, Yasuharu, Iio, Sadaharu, Tatsumi, Tomohide, Takehara, Tetsuo

“…L31 and Y93 in the NS5A region of the hepatitis C virus (HCV) are the most important substitution positions associated with resistance to direct-acting…”
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An age-group analysis on the efficacy of chemotherapy in older adult patients with metastatic biliary tract cancer: a Japanese cancer registry cohort study by Hirao, Takeru, Ikezawa, Kenji, Morishima, Toshitaka, Daiku, Kazuma, Seiki, Yusuke, Watsuji, Ko, Kawamoto, Yasuharu, Higashi, Sena, Urabe, Makiko, Kai, Yugo, Takada, Ryoji, Yamai, Takuo, Mukai, Kaori, Nakabori, Tasuku, Uehara, Hiroyuki, Miyashiro, Isao, Ohkawa, Kazuyoshi

“…The effectiveness of chemotherapy in older adult patients with biliary tract cancer (BTC) remains to be established, despite the fact that the majority of…”
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A case of refractory tumor bleeding from an ampullary adenocarcinoma: Compression hemostasis with a self‐expandable metallic stent by Daiku, Kazuma, Ikezawa, Kenji, Maeda, Shingo, Abe, Yutaro, Kai, Yugo, Takada, Ryoji, Yamai, Takuo, Fukutake, Nobuyasu, Nakabori, Tasuku, Uehara, Hiroyuki, Ohkawa, Kazuyoshi

“…Although patients with ampullary cancers frequently experience obstructive jaundice and tumor bleeding, there have been few reports on efficient management of…”
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5-Fluorouracil/L-Leucovorin Plus Oxaliplatin (FOLFOX) Regimen as Salvage Chemotherapy for Patients with Unresectable Pancreatic Cancer Receiving Gemcitabine and Nab-Paclitaxel and 5-Fluorouracil/L-Leucovorin Plus Nanoliposomal Irinotecan: Preliminary Results from Clinical Practice by Yamai, Takuo, Ikezawa, Kenji, Kawamoto, Yasuharu, Hirao, Takeru, Higashi, Sena, Daiku, Kazuma, Maeda, Shingo, Abe, Yutaro, Urabe, Makiko, Kai, Yugo, Takada, Ryoji, Nakabori, Tasuku, Uehara, Hiroyuki, Ohkawa, Kazuyoshi

“…Salvage chemotherapy for patients with unresectable pancreatic cancer (UR-PC) who have been treated with gemcitabine and nab-paclitaxel (GnP), and…”
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Real‐world assessment of comprehensive genome profiling impact on clinical outcomes: A single‐institution study in Japan by Kunimasa, Kei, Sugimoto, Naotoshi, Yamasaki, Tomoyuki, Kukita, Yoji, Fujisawa, Fumie, Inoue, Tazuko, Yamaguchi, Yuko, Kitasaka, Mitsuko, Sakai, Daisuke, Honma, Keiichiro, Wakamatsu, Toru, Yamamoto, Sachiko, Hayashi, Takuji, Mabuchi, Seiji, Okuno, Jun, Kawamura, Takahisa, Kai, Yugo, Urabe, Makiko, Nishimura, Kazuo

“…Introduction Comprehensive genome profiling (CGP) has revolutionized healthcare by offering personalized medicine opportunities. However, its real‐world…”
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Oil blotting paper for formalin fixation increases endoscopic ultrasound‐guided tissue acquisition‐collected sample volumes on glass slides by Yamai, Takuo, Ikezawa, Kenji, Seiki, Yusuke, Watsuji, Ko, Kawamoto, Yasuharu, Hirao, Takeru, Daiku, Kazuma, Maeda, Shingo, Urabe, Makiko, Kai, Yugo, Takada, Ryoji, Mukai, Kaori, Nakabori, Tasuku, Uehara, Hiroyuki, Tsuzaki, Sayoko, Ryu, Ayumi, Tanada, Satoshi, Nagata, Shigenori, Ohkawa, Kazuyoshi

“…Objectives Endoscopic ultrasound‐guided tissue acquisition (EUS‐TA) is used for pathological diagnosis and obtaining samples for molecular testing,…”
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Baseline quasispecies selection and novel mutations contribute to emerging resistance-associated substitutions in hepatitis C virus after direct-acting antiviral treatment by Kai, Yugo, Hikita, Hayato, Morishita, Naoki, Murai, Kazuhiro, Nakabori, Tasuku, Iio, Sadaharu, Hagiwara, Hideki, Imai, Yasuharu, Tamura, Shinji, Tsutsui, Syusaku, Naito, Masafumi, Nishiuchi, Meiko, Kondo, Yasuteru, Kato, Takanobu, Suemizu, Hiroshi, Yamada, Ryoko, Oze, Tsugiko, Yakushijin, Takayuki, Hiramatsu, Naoki, Sakamori, Ryotaro, Tatsumi, Tomohide, Takehara, Tetsuo

“…Resistance-associated substitutions (RASs) in hepatitis C virus (HCV) appear upon failure of treatment with direct-acting antivirals (DAAs). However, their…”
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