Search Results - "Yuen Yi C. Tam"

Protective Effect of Edaravone against Cationic Lipid-Mediated Oxidative Stress and Apoptosis by Terada, Takeshi, Kulkarni, Jayesh A, Huynh, Ariel, Tam, Yuen Yi C., Cullis, Pieter

“…Liposomes containing ionizable cationic lipids have been widely used for the delivery of nucleic acids such as small-interfering RNA and mRNA. The utility of…”
Get full text

On the role of helper lipids in lipid nanoparticle formulations of siRNA by Kulkarni, Jayesh A, Witzigmann, Dominik, Leung, Jerry, Tam, Yuen Yi C, Cullis, Pieter R

“…Onpattro, the first RNAi-based therapeutic to receive FDA approval, is enabled by a lipid nanoparticle (LNP) system that facilitates siRNA delivery into the…”
Get more information

Influence of cationic lipid composition on uptake and intracellular processing of lipid nanoparticle formulations of siRNA by Lin, Paulo J.C., PhD, Tam, Yuen Yi C., PhD, Hafez, Ismail, PhD, Sandhu, Ammen, PhD, Chen, Sam, BSc, Ciufolini, Marco A., PhD, Nabi, Ivan R., PhD, Cullis, Pieter R., PhD

“…Abstract The in vivo gene silencing potencies of lipid nanoparticle (LNP)-siRNA systems containing the ionizable cationic lipids DLinDAP, DLinDMA, DLinKDMA, or…”
Get full text

On the Formation and Morphology of Lipid Nanoparticles Containing Ionizable Cationic Lipids and siRNA by Kulkarni, Jayesh A, Darjuan, Maria M, Mercer, Joanne E, Chen, Sam, van der Meel, Roy, Thewalt, Jenifer L, Tam, Yuen Yi C, Cullis, Pieter R

“…Lipid nanoparticles (LNPs) containing short interfering RNA (LNP-siRNA) and optimized ionizable cationic lipids are now clinically validated systems for…”
Get full text

Characterization of Lipid Nanoparticles Containing Ionizable Cationic Lipids Using Design-of-Experiments Approach by Terada, Takeshi, Kulkarni, Jayesh A, Huynh, Ariel, Chen, Sam, van der Meel, Roy, Tam, Yuen Yi C, Cullis, Pieter R

“…Lipid nanoparticles (LNPs) containing short-interfering RNA (LNP-siRNA systems) are a promising approach for silencing disease-causing genes in hepatocytes…”
Get full text

Influence of particle size on the in vivo potency of lipid nanoparticle formulations of siRNA by Chen, Sam, Tam, Yuen Yi C., Lin, Paulo J.C., Sung, Molly M.H., Tam, Ying K., Cullis, Pieter R.

“…Lipid nanoparticles (LNP) can provide a clinically effective method for delivering small interfering RNA (siRNA) to silence pathological genes in hepatocytes…”
Get full text

Small molecule ligands for enhanced intracellular delivery of lipid nanoparticle formulations of siRNA by Tam, Yuen Yi C., PhD, Chen, Sam, BSc, Zaifman, Josh, PhD, Tam, Ying K., PhD, Lin, Paulo J.C., PhD, Ansell, Steven, PhD, Roberge, Michel, PhD, Ciufolini, Marco A., PhD, Cullis, Pieter R., PhD

“…Abstract Gene silencing activity of lipid nanoparticle (LNP) formulations of siRNA requires LNP surface factors promoting cellular uptake. This study aimed to…”
Get full text

Development of lipid nanoparticles and liposomes reference materials (II): cytotoxic profiles by Syama, Krishnapriya, Jakubek, Zygmunt J., Chen, Sam, Zaifman, Josh, Tam, Yuen Yi C., Zou, Shan

“…Lipid based nanocarriers are one of the most effective drug delivery systems that is evident from the recent COVID-19 mRNA vaccines. The main objective of this…”
Get full text

Spontaneous, solvent-free entrapment of siRNA within lipid nanoparticles by Kulkarni, Jayesh A, Thomson, Sarah B, Zaifman, Josh, Leung, Jerry, Wagner, Pamela K, Hill, Austin, Tam, Yuen Yi C, Cullis, Pieter R, Petkau, Terri L, Leavitt, Blair R

“…Lipid nanoparticle (LNP) formulations of nucleic acid are leading vaccine candidates for COVID-19, and enabled the first approved RNAi therapeutic, Onpattro…”
Get more information

Development of lipid nanoparticle formulations of siRNA for hepatocyte gene silencing following subcutaneous administration by Chen, Sam, Tam, Yuen Yi C., Lin, Paulo J.C., Leung, Alex K.K., Tam, Ying K., Cullis, Pieter R.

“…Recently developed lipid nanoparticle (LNP) formulations of siRNA have proven to be effective agents for hepatocyte gene silencing following intravenous…”
Get full text

Dexamethasone prodrugs as potent suppressors of the immunostimulatory effects of lipid nanoparticle formulations of nucleic acids by Chen, Sam, Zaifman, Josh, Kulkarni, Jayesh A., Zhigaltsev, Igor V., Tam, Ying K., Ciufolini, Marco A., Tam, Yuen Yi C., Cullis, Pieter R.

“…Lipid nanoparticles (LNPs) are playing a leading role in enabling clinical applications of gene therapies based on DNA or RNA polymers. One factor impeding…”
Get full text

Lipid Nanoparticles for Short Interfering RNA Delivery by Leung, Alex K K, Tam, Yuen Yi C, Cullis, Pieter R

“…The discovery of RNA interference (RNAi) in mammalian cells has created a new class of therapeutics based on the reversible silencing of specific…”
Get full text

Interaction landscape of membrane-protein complexes in Saccharomyces cerevisiae by Babu, Mohan, Vlasblom, James, Pu, Shuye, Guo, Xinghua, Graham, Chris, Bean, Björn D. M., Burston, Helen E., Vizeacoumar, Franco J., Snider, Jamie, Phanse, Sadhna, Fong, Vincent, Tam, Yuen Yi C., Davey, Michael, Hnatshak, Olha, Bajaj, Navgeet, Chandran, Shamanta, Punna, Thanuja, Christopolous, Constantine, Wong, Victoria, Yu, Analyn, Zhong, Gouqing, Li, Joyce, Stagljar, Igor, Conibear, Elizabeth, Wodak, Shoshana J., Emili, Andrew, Greenblatt, Jack F.

“…A survey of 1,590 putative integral, peripheral and lipid-anchored membrane proteins from Saccharomyces cerevisiae reveals unexpected physical associations…”
Get full text

The Niemann-Pick C1 Inhibitor NP3.47 Enhances Gene Silencing Potency of Lipid Nanoparticles Containing siRNA by Wang, Haitang, Tam, Yuen Yi C, Chen, Sam, Zaifman, Josh, van der Meel, Roy, Ciufolini, Marco A, Cullis, Pieter R

“…The therapeutic applications of lipid nanoparticle (LNP) formulations of small interfering RNA (siRNA), are hampered by inefficient delivery of encapsulated…”
Get full text

Advances in Lipid Nanoparticles for siRNA Delivery by Tam, Yuen Yi C, Chen, Sam, Cullis, Pieter R

“…Technological advances in both siRNA (small interfering RNA) and whole genome sequencing have demonstrated great potential in translating genetic information…”
Get full text

Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles by Mui, Barbara L, Tam, Ying K, Jayaraman, Muthusamy, Ansell, Steven M, Du, Xinyao, Tam, Yuen Yi C, Lin, Paulo JC, Chen, Sam, Narayanannair, Jayaprakash K, Rajeev, Kallanthottathil G, Manoharan, Muthiah, Akinc, Akin, Maier, Martin A, Cullis, Pieter, Madden, Thomas D, Hope, Michael J

“…Lipid nanoparticles (LNPs) encapsulating short interfering RNAs that target hepatic genes are advancing through clinical trials, and early results indicate the…”
Get full text

Influence of Cationic Lipid Composition on Gene Silencing Properties of Lipid Nanoparticle Formulations of siRNA in Antigen-Presenting Cells by Basha, Genc, Novobrantseva, Tatiana I, Rosin, Nicole, Tam, Yuen Yi C, Hafez, Ismail M, Wong, Matthew K, Sugo, Tsukasa, Ruda, Vera M, Qin, June, Klebanov, Boris, Ciufolini, Marco, Akinc, Akin, Tam, Ying K, Hope, Michael J, Cullis, Pieter R

“…Lipid nanoparticles (LNPs) are currently the most effective in vivo delivery systems for silencing target genes in hepatocytes employing small interfering RNA…”
Get full text

Pex3p Initiates the Formation of a Preperoxisomal Compartment from a Subdomain of the Endoplasmic Reticulum in Saccharomyces cerevisiae by Tam, Yuen Yi C., Fagarasanu, Andrei, Fagarasanu, Monica, Rachubinski, Richard A.

“…Peroxisomes are dynamic organelles that often proliferate in response to compounds that they metabolize. Peroxisomes can proliferate by two apparent…”
Get full text

Molecular Architecture and Functional Model of the Complete Yeast ESCRT-I Heterotetramer by Kostelansky, Michael S., Schluter, Cayetana, Tam, Yuen Yi C., Lee, Sangho, Ghirlando, Rodolfo, Beach, Bridgette, Conibear, Elizabeth, Hurley, James H.

“…The endosomal sorting complex required for transport-I (ESCRT-I) complex, which is conserved from yeast to humans, directs the lysosomal degradation of…”
Get full text

Lipid nanoparticle delivery of glucagon receptor siRNA improves glucose homeostasis in mouse models of diabetes by Neumann, Ursula H., Ho, Jessica S.S., Chen, Sam, Tam, Yuen Yi C., Cullis, Pieter R., Kieffer, Timothy J.

“…Hyperglucagonemia is present in many forms of diabetes and contributes to hyperglycemia, and glucagon suppression can ameliorate diabetes in mice. Leptin, a…”
Get full text