Search Results - "Yue, Lynn"

P087: Retrospective analysis of comprehensive cancer panel sequencing at Fox Chase Cancer Center to evaluate the QIAGEN Clinical Insight Interpret database by Guo, Tingwei, Baldwin, Don, Tan, Yinfei, Gong, Yulan, Huang, Min, Mackrides, Nicholas, Nejati, Reza, Wang, Yue Lynn, Wasik, Mariusz

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Weekly glucagon‐like peptide‐1 receptor agonist albiglutide as monotherapy improves glycemic parameters in Japanese patients with type 2 diabetes mellitus: A randomized, double‐blind, placebo‐controlled study by Nino, Antonio, Okuda, Inaha, Wilson, Timothy H, Yue, Lynn, Nakajima, Hiromu, Tsuboi, Maho, Carr, Molly C, Seino, Yutaka

“…Aims/Introduction The present phase 3, randomized, double‐blind 24‐week study with extension to 1 year assessed the efficacy and safety of albiglutide compared…”
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Identification of a structurally novel BTK mutation that drives ibrutinib resistance in CLL by Sharma, Shruti, Galanina, Natalie, Guo, Ailin, Lee, Jimmy, Kadri, Sabah, Van Slambrouck, Charles, Long, Bradley, Wang, Weige, Ming, Mei, Furtado, Larissa V, Segal, Jeremy P, Stock, Wendy, Venkataraman, Girish, Tang, Wei-Jen, Lu, Pin, Wang, Yue Lynn

“…Ibrutinib (ibr), a first-in-class Bruton tyrosine kinase (BTK) inhibitor, has demonstrated high response rates in both relapsed/refractory and treatment naïve…”
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HSP90 Stabilizes B-Cell Receptor Kinases in a Multi-Client Interactome: PU-H71 Induces CLL Apoptosis in a Cytoprotective Microenvironment by Wang, Yue Lynn, Lu, Pin, Lee, Jimmy, Zhen, Chao Jie, Chiosis, Gabriela, Guo, Ailin

“…Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of B-cells in the hematopoietic system and lymphoid tissues. Although inhibitors…”
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Dual SYK/JAK Inhibition Overcomes Ibrutinib Resistance in Chronic Lymphocytic Leukemia by Wang, Yue Lynn, Lu, Pin, Coffey, Greg P, Pandey, Anjali, Guo, Ailin

“…Ibrutinib (a BTK inhibitor) has generated remarkable responses in CLL. However, the drug, to a large extent, does not cause cell death directly and does not…”
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Higher BTK-Dependent Cell Proliferation in Unmutated Chronic Lymphocytic Leukemia Confers Increased Sensitivity to Ibrutinib by Guo, Ailin, Lu, Pin, Galanina, Natalie, Nabhan, Chadi, Smith, Sonali M., Coleman, Morton, Wang, Yue Lynn

“…In chronic lymphocytic leukemia (CLL), mutation status of the immunoglobulin heavy chain variable region gene (IGHV) has prognostic significance, with the…”
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An HSP90 Inhibitor, PU-H71, Antagonizes Stroma-Induced Pro-Survival Effects in CLL through Its Inhibition of Multi-Component B-Cell Receptor Signaling Pathway by Guo, Ailin, Lu, Pin, Zhen, Chaojie, Chiosis, Gabriela, Wang, Yue Lynn

“…Background: Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of B-cells in the hematopoietic system. The B-cell receptor (BCR) plays an…”
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An Accurate and Sensitive RT-qPCR Method That Reliably Detects BCR-ABL1 Beyond MR4.5 by McDonald, Nadia A., Close, Brett E., Lu, Pin, Segal, Jeremy P., Wang, Yue Lynn, Furtado, Larissa V.

“…▪ Introduction: The BCR-ABL1 translocation is a hallmark of chronic myeloid leukemia (CML). As levels of BCR-ABL1 reflect leukemia burden, quantitation of…”
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Mechanisms of ibrutinib resistance in chronic lymphocytic leukaemia and non‐Hodgkin lymphoma by Zhang, Shuang Q., Smith, Sonali M., Zhang, Shuang Y., Lynn Wang, Yue

“…Summary Bruton tyrosine kinase (BTK), a mediator of B‐cell receptor (BCR) signalling, has been implicated in the pathogenesis of chronic lymphocytic leukaemia…”
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Regulation of self-tolerance by CD80/CD86 interactions by Lu, Pin, Wang, Yue Lynn, Linsley, Peter S

“…Antigen presentation by CD80/CD86-positive ‘professional APCs’ induces T-cell activation, whereas antigen presentation in the absence of sufficient CD80/CD86…”
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Controlling ubiquitous transcription from the alpha 1-tubulin gene of Drosophila melanogaster by Wang, Yue Lynn

“…This study examines the ubiquitously expressed gene, the $\alpha$1-tubulin gene ($\alpha$1t) from Drosophila melanogaster, to better understand the mechanism…”
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