Search Results - "Yudoh, Kazuo"

Bone Development and Regeneration 2.0 by Yudoh, Kazuo, Sugishita, Yodo, Suzuki-Takahashi, Yuki

“…Bone is an important tissue which is a structural body component, carrying out the roles of mechanical stress response and organ/tissue protection [...]…”
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Statin prevents chondrocyte aging and degeneration of articular cartilage in osteoarthritis (OA) by Yudoh, Kazuo, Karasawa, Rie

“…Recent reports have shown that statin (HMG-CoA reductase inhibitors) may have the potential to inhibit inflammatory arthritis. More recently, the idea that…”
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Physiologic Mechanical Stress Directly Induces Bone Formation by Activating Glucose Transporter 1 (Glut 1) in Osteoblasts, Inducing Signaling via NAD+-Dependent Deacetylase (Sirtuin 1) and Runt-Related Transcription Factor 2 (Runx2) by Somemura, Shu, Kumai, Takanori, Yatabe, Kanaka, Sasaki, Chizuko, Fujiya, Hiroto, Niki, Hisateru, Yudoh, Kazuo

“…Mechanical stress is an important factor affecting bone tissue homeostasis. We focused on the interactions among mechanical stress, glucose uptake via glucose…”
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Streptococcal infection and autoimmune diseases by Ohashi, Ayaka, Murayama, Masanori A, Miyabe, Yoshishige, Yudoh, Kazuo, Miyabe, Chie

“…Excessive activation of immune cells by environmental factors, such as infection or individual genetic risk, causes various autoimmune diseases. species are…”
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Positive feedback loop via astrocytes causes chronic inflammation in virus-associated myelopathy by ANDO, Hitoshi, SATO, Tomoo, YUDOH, Kazuo, HASEGAWA, Yasuhiro, NISHIOKA, Kusuki, NAKAJIMA, Toshihiro, JACOBSON, Steven, YAMANO, Yoshihisa, TOMARU, Utano, YOSHIDA, Mari, UTSUNOMIYA, Atae, YAMAUCHI, Junji, ARAYA, Natsumi, YAGISHITA, Naoko, COLER-REILLY, Ariella, SHIMIZU, Yukiko

“…Human T-lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a rare neurodegenerative disease characterized by chronic…”
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A novel, self-assembled artificial cartilage-hydroxyapatite conjugate for combined articular cartilage and subchondral bone repair: histopathological analysis of cartilage tissue engineering in rat knee joints by Kumai, Takanori, Yui, Naoko, Yatabe, Kanaka, Sasaki, Chizuko, Fujii, Ryoji, Takenaga, Mitsuko, Fujiya, Hiroto, Niki, Hisateru, Yudoh, Kazuo

“…We previously created a self-assembled cartilage-like complex in vitro from only three cartilage components, hyaluronic acid (HA), aggrecan (AG) and type II…”
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The NAD-Dependent Deacetylase Sirtuin-1 Regulates the Expression of Osteogenic Transcriptional Activator Runt-Related Transcription Factor 2 (Runx2) and Production of Matrix Metalloproteinase (MMP)-13 in Chondrocytes in Osteoarthritis by Terauchi, Koh, Kobayashi, Hajime, Yatabe, Kanaka, Yui, Naoko, Fujiya, Hiroto, Niki, Hisateru, Musha, Haruki, Yudoh, Kazuo

“…Aging is one of the major pathologic factors associated with osteoarthritis (OA). Recently, numerous reports have demonstrated the impact of sirtuin-1 (Sirt1),…”
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SPACIA1/SAAL1 Deletion Results in a Moderate Delay in Collagen-Induced Arthritis Activity, along with mRNA Decay of Cyclin-dependent Kinase 6 Gene by Fujii, Ryoji, Komatsu, Rie, Sato, Tomoo, Seki, Iwao, Konomi, Koji, Aono, Hiroyuki, Niki, Hisateru, Yudoh, Kazuo, Nishioka, Kusuki, Nakajima, Toshihiro

“…This study was performed to elucidate the molecular function of the synoviocyte proliferation-associated in collagen-induced arthritis (CIA) 1/serum amyloid…”
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Organ involvement pattern suggests subgroups within relapsing polychondritis: comment on the article by Dion et al by Shimizu, Jun, Yamano, Yoshihisa, Yudoh, Kazuo, Suzuki, Noboru

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The DNA repair enzyme apurinic/apyrimidinic endonuclease (Apex nuclease) 2 has the potential to protect against down-regulation of chondrocyte activity in osteoarthritis by Yui, Naoko, Yoshioka, Hirotaka, Fujiya, Hiroto, Musha, Haruki, Beppu, Moroe, Karasawa, Rie, Yudoh, Kazuo

“…Apurinic/apyrimidinic endonuclease 2 (Apex 2) plays a critical role in DNA repair caused by oxidative damage in a variety of human somatic cells. We speculated…”
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Identification of novel citrullinated autoantigens of synovium in rheumatoid arthritis using a proteomic approach by Matsuo, Kosuke, Xiang, Yang, Nakamura, Hiroshi, Masuko, Kayo, Yudoh, Kazuo, Noyori, Koji, Nishioka, Kusuki, Saito, Tomoyuki, Kato, Tomohiro

“…Recently, autoantibodies to some citrullinated autoantigens have been reported to be specific for rheumatoid arthritis (RA). However, an entire profile of and…”
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Secretion of inflammatory factors from chondrocytes by layilin signaling by Asano, Kota, Arito, Mitsumi, Kurokawa, Manae S., Omoteyama, Kazuki, Okamoto, Kazuki, Suematsu, Naoya, Yudoh, Kazuo, Nakamura, Hiroshi, Beppu, Moroe, Kato, Tomohiro

“…•TNF-α up-regulates expression of layilin (LAYN) in human articular chondrocytes.•Human articular chondrocytes produce complement5 (C5).•Activation of the LAYN…”
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Effects of an oral administration of glucosamine-chondroitin-quercetin glucoside on the synovial fluid properties in patients with osteoarthritis and rheumatoid arthritis by Matsuno, H.(Matsuno Clinic for Rheumatic Diseases, Toyama (Japan)), Nakamura, H, Katayama, K, Hayashi, S, Kano, S, Yudoh, K, Kiso, Y

“…The effects of an orally administered combination of a glucosamine-chondroitin-quercetin glucoside (GCQG) supplement on the synovial fluid properties of…”
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Anti-inflammatory effects of hyaluronan in arthritis therapy: Not just for viscosity by Masuko, Kayo, Murata, Minako, Yudoh, Kazuo, Kato, Tomohiro, Nakamura, Hiroshi

“…Hyaluronic acid (HA) has been widely used for viscosupplementation of diseased or aged articular joints. However, recent investigations have revealed the…”
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Implication of granulocyte-macrophage colony-stimulating factor induced neutrophil gelatinase-associated lipocalin in pathogenesis of rheumatoid arthritis revealed by proteome analysis by Katano, Masayoshi, Okamoto, Kazuki, Arito, Mitsumi, Kawakami, Yuki, Kurokawa, Manae S, Suematsu, Naoya, Shimada, Sonoko, Nakamura, Hiroshi, Xiang, Yang, Masuko, Kayo, Nishioka, Kusuki, Yudoh, Kazuo, Kato, Tomohiro

“…In rheumatoid arthritis (RA), synovial fluid (SF)contains a large number of neutrophils that contribute to the inflammation and destruction of the joints. The…”
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Mechanical and oxidative stress in osteoarthritis by Naoko Yui, Kazuo Yudoh, Hiroto Fujiya, Haruki Musha

“…Osteoarthritis (OA) is one of the most common age-related degenerative joint disorders. In addition to aging, various life-style-related factors, such as…”
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Effects of Different Exercise Conditions on Antioxidant Potential and Mental Assessment by Yatabe, Kanaka, Muroi, Ryota, Kumai, Takanori, Kotani, Takashi, Somemura, Shu, Yui, Naoko, Murofushi, Yuka, Terawaki, Fumiko, Kobayashi, Hajime, Yudoh, Kazuo, Sakurai, Hiroyuki, Miyano, Hisao, Fujiya, Hiroto

“…Exercise increases oxidative stress, leading the body to strengthen its antioxidant defenses, thus reducing the incidence of major diseases. As these…”
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Serum level of soluble triggering receptor expressed on myeloid cells-1 as a biomarker of disease activity in relapsing polychondritis by Sato, Tomoo, Yamano, Yoshihisa, Tomaru, Utano, Shimizu, Yukiko, Ando, Hitoshi, Okazaki, Takahiro, Nagafuchi, Hiroko, Shimizu, Jun, Ozaki, Shoichi, Miyazawa, Teruomi, Yudoh, Kazuo, Oka, Hiroshi, Suzuki, Noboru

“…Abstract Objectives We aimed to identify a serum biomarker for evaluating the disease activity of relapsing polychondritis (RP). Methods We measured and…”
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Water-soluble fullerene (C60) inhibits the development of arthritis in the rat model of arthritis by Yudoh, Kazuo, Karasawa, Rie, Masuko, Kayo, Kato, Tomohiro

“…Recently, it has been demonstrated that oxygen free radicals have an important role as a signaling messenger in the development of inflammation and…”
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Sphingosine-1-phosphate attenuates proteoglycan aggrecan expression via production of prostaglandin E2 from human articular chondrocytes by Masuko, Kayo, Murata, Minako, Nakamura, Hiroshi, Yudoh, Kazuo, Nishioka, Kusuki, Kato, Tomohiro

“…Sphingosine-1-phosphate (S1P), a downstream metabolite of ceramide, induces various bioactivities via two distinct pathways: as an intracellular second…”
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