Search Results - "Yudoh, K."

The potential role of vascular endothelial growth factor (VEGF) in cartilage: how the angiogenic factor could be involved in the pathogenesis of osteoarthritis? by Murata, M, Yudoh, K, Masuko, K

“…Although adult human cartilage is physiologically avascular tissue, angiogenesis can be observed during the process of endochondral bone development…”
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Interleukin (IL) 18 stimulates osteoclast formation through synovial T cells in rheumatoid arthritis: comparison with IL1β and tumour necrosis factor α by Dai, S-M, Nishioka, K, Yudoh, K

“…Objective: To determine whether IL18 has any indirect effects on osteoclastogenesis mediated by T cells in RA synovium, and compare its effects with those of…”
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Impact of NAD-dependent deacetylase Sirtuin-1 in the osteophyte formation and the degradation of articular cartilage in osteoarthritis (OA) by Yudoh, K, Terauchi, K, Yui, N, Kobayashi, H, Fujiya, H, Niki, H, Musha, H

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The role of subchondral bone resorption pits in osteoarthritis: MMP production by cells derived from bone marrow by Shibakawa, A., Yudoh, K., Masuko-Hongo, K., Kato, T., Nishioka, K., Nakamura, H.

“…The vascular invasion of bone marrow tissue into the subchondral plate is often observed in articular cartilage and we named it the subchondral bone absorption…”
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DNA oxidative damage and its repair enzyme (Ogg1) in osteoarthritic chondrocytes by Yudoh, K, Karasawa, R, Yui, N, Yoshioka, H

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Impairment of mitochondrial 8-oxoguanine DNA glycosylase (Ogg1) against accumulation OF 8-oxoguanine in osteoartiritic chondrocytes by Yudoh, K, Karasawa, R

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A metabolic aspect of osteoarthritis: lipid as a possible contributor to the pathogenesis of cartilage degradation by MASUKO, K, MURATA, M, SUEMATSU, N, OKAMOTO, K, YUDOH, K, NAKAMURA, H, KATO, T

“…Osteoarthritis (OA) is considered to be linked to obesity and body fat mass. Recent investigations, however, are aimed at clarifying the roles of adipose…”
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DNA repair enzyme, apurinic/apyrimidinic endonuclease 2 (Apex2), has a potential to protect against the down-regulation of condrocyte activity in osteoarthritis by Yui, N, Yudoh, K, Karasawa, R, Yoshioka, H, Musha, H

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Mitochondrial DNA repair enzyme OGG1 is essential for protection against the downregulation of chondrocyte activity in OA by Yudoh, K, Karasawa, R, Yui, N

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Water-soluble C60-(OH)24 fullerene hydroxide as a therapeutic agent against the degeneration of articular cartilage in osteoarthritis by Yui, N, Yoshioka, H, Fujiya, H, Musha, H, Karasawa, R, Yudoh, K

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The role of atp-activated protein kinase(AMPK) in the chondrocyte energy balance and IL-1β-induced production of MMP-13 in osteoarthritis(OA) by Yui, N, Kobayashi, H, Terauchi, K, Yoshioka, H, Fujiya, H, Niki, H, Musha, H, Yudoh, K

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NAD-dependent deacetylase Sirtuin-1 down-regulates expressions of osteogenic transcription facter RUNX2 and matrix metaprotinase (MMP)-13 in osteoarthritic chondrocytes by Terauchi, K, Yui, N, Kobayashi, H, Yoshioka, H, Fujiya, H, Niki, H, Musha, H, Yudoh, K

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Peroxiredoxin 2 is a novel autoantigen for anti‐endothelial cell antibodies in systemic vasculitis by Karasawa, R., Kurokawa, M. S., Yudoh, K., Masuko, K., Ozaki, S., Kato, T.

“…Summary Anti‐endothelial cell antibodies (AECA) have been frequently detected in systemic vasculitis, which affects blood vessels of various sizes. To…”
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Telomerized presenescent osteoblasts prevent bone mass loss in vivo by YUDOH, K, NISHIOKA, K

“…Previously, we showed that human osteoblasts expressing the human telomerase reverse transcriptase (hTERT) gene exhibited specific survival advantages--the…”
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The role of TNF‐α in the pathogenesis of inflammation and joint destruction in rheumatoid arthritis (RA): a study using a human RA/SCID mouse chimera by Matsuno, H., Yudoh, K., Katayama, R., Nakazawa, F., Uzuki, M., Sawai, T., Yonezawa, T., Saeki, Y., Panayi, G. S., Pitzalis, C., Kimura, T.

“…Objective. In order to elucidate which cytokine preferentially stimulates the synovium in patients with rheumatoid arthritis (RA), we investigated the roles of…”
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Concentration of vascular endothelial growth factor in the tumour tissue as a prognostic factor of soft tissue sarcomas by YUDOH, K, KANAMORI, M, OHMORI, K, YASUDA, T, AOKI, M, KIMURA, T

“…Previous studies have shown that the prognosis of patients who have tumours with high microvessel density (MVD) is worse than that of patients who have a lower…”
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Stromelysin-1 (MMP-3) in synovial fluid of patients with rheumatoid arthritis has potential to cleave membrane bound Fas ligand by MATSUNO, Hiroaki, YUDOH, Kazuo, WATANABE, Yasuhiro, NAKAZAWA, Fujio, AONO, Hiroyuki, KIMURA, Tomoatsu

“…OBJECTIVE: To investigate the relationship between matrix metalloproteinases (MMP) and the soluble form of Fas ligand (sFasL) in the synovial fluid (SF) of…”
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Implication of interleukin 18 in production of matrix metalloproteinases in articular chondrocytes in arthritis: direct effect on chondrocytes may not be pivotal by Dai, S-M, Shan, Z-Z, Nishioka, K, Yudoh, K

“…Objective: To clarify the effect of interleukin (IL) 18 on cartilage degeneration by studying the profile of IL18 receptor (IL18R) on chondrocytes and the…”
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ACTIVATION OFGLUCOSE TRANSPORTER 1 (GLUT1) IS REQUIRED FOR THE MECHANICAL STRESS-INDUCED BONE FORMATIONVIA THE SIGNAL TRANSDUCTION NETWORK BETWEEN THE CELLULAR ENERGY SENSOR, NAD+-DEPENDENT DEACETYLASE (SIRTUIN1), AND THE OSTEOGENIC TRANSCRIPTION FACTOR, RUNT-RELATED TRANSCRIPTION FACTOR 2 (RUNX2), IN OSTEOBLASTS by Yudoh, K., Somemura, S.

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Reconstituting Telomerase Activity Using the Telomerase Catalytic Subunit Prevents the Telomere Shorting and Replicative Senescence in Human Osteoblasts by Yudoh, Kazuo, Matsuno, Hiroaki, Nakazawa, Fujio, Katayama, Rie, Kimura, Tomoatsu

“…The rate of bone formation is largely determined by the number of osteoblasts, which in turn is determined by the rate of replication of progenitors and the…”
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