CYP2D6 phenotype and ABCB1 haplotypes are associated with antipsychotic safety in adolescents experiencing acute psychotic episodes

To identify possible associations of , and gene polymorphisms with the efficacy and safety of antipsychotics in adolescents with acute psychotic episodes. We examined the associations of pharmacogenetic factors with the efficacy and safety of antipsychotics in 101 adolescents with acute psychotic ep...

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Bibliographic Details
Published in:	Drug metabolism and personalized therapy Vol. 37; no. 1; p. 47
Main Authors:	Ivashchenko, Dmitriy V, Yudelevich, Daria A, Buromskaya, Nina I, Shimanov, Pavel V, Deitch, Roman V, Akmalova, Kristina A, Kachanova, Anastasia A, Dorina, Irina V, Nastovich, Marina I, Grishina, Elena A, Savchenko, Lyudmila M, Shevchenko, Yuriy S, Sychev, Dmitriy A
Format:	Journal Article
Language:	English
Published:	Germany 12-08-2021
Subjects:	Adolescent Antipsychotic Agents - adverse effects ATP Binding Cassette Transporter, Subfamily B - genetics ATP Binding Cassette Transporter, Subfamily B, Member 1 - genetics Cytochrome P-450 CYP2D6 - genetics Cytochrome P-450 CYP2D6 - metabolism Genotype Haplotypes Humans Phenotype Polymorphism, Single Nucleotide - genetics Psychotic Disorders - drug therapy Psychotic Disorders - genetics ABCB1 CYP2D6 adolescents antipsychotic pharmacogenetic
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Summary:	To identify possible associations of , and gene polymorphisms with the efficacy and safety of antipsychotics in adolescents with acute psychotic episodes. We examined the associations of pharmacogenetic factors with the efficacy and safety of antipsychotics in 101 adolescents with acute psychotic episodes. The diagnosis on admission was "Brief psychotic disorder" (F23.0-23.9 by ICD-10). All patients were administered antipsychotics for 14 days. Treatment efficacy and safety were assessed using the PANSS, CGAS, CGI-S(I), UKU SERS, BARS, and SAS scales. Pharmacokinetic genotyping was performed for the * * , 1236C>T, 2677G>T, and 3435C>T genes. CYP2D6 intermediate metabolisers had "Micturition disturbances" more often than extensive metabolisers (24.2 vs. 7.4%; p=0.026). "Wild" homozygote 3435C>T CC was associated with more prominent akathisia. Haplotype analysis of three polymorphisms revealed that the "wild" alleles "C-G-C" (ABCB1 1236-2677-3435) were associated with higher risk of "Reduced salivation" (OR=2.95; 95% CI=1.35-6.45; p=0.0078). CYP2D6 intermediate metabolism was associated with the risk of urinary difficulties under treatment with antipsychotics. We found that "wild" homozygotes 1236C>T, 2677G>T, and 3435C>T were predictors of adverse drug effects caused by treatment with antipsychotics.
ISSN:	2363-8915