Search Results - "Yuan, Yuren Adam"
-
1
Structures of apo Cas12a and its complex with crRNA and DNA reveal the dynamics of ternary complex formation and target DNA cleavage
Published in PLoS biology (14-03-2023)“…Cas12a is a programmable nuclease for adaptive immunity against invading nucleic acids in CRISPR-Cas systems. Here, we report the crystal structures of apo…”
Get full text
Journal Article -
2
Structural insights into Drosophila-C3PO complex assembly and 'Dynamic Side Port' model in substrate entry and release
Published in Nucleic acids research (19-09-2018)“…Abstract In Drosophila and human, component 3 promoter of RISC (C3PO), a heteromeric complex, enhances RISC assembly and promotes RISC activity. Here, we…”
Get full text
Journal Article -
3
Structural and mechanistic insight into stem‐loop RNA processing by yeast Pichia stipitis Dicer
Published in Protein science (01-06-2021)“…Dicer is a member of the ribonuclease III enzyme family and processes double‐stranded RNA into small functional RNAs. The variation in the domain architecture…”
Get full text
Journal Article -
4
Overexpression of AmpC Promotes Bacteriophage Lysis of Ampicillin-Resistant Escherichia coli
Published in Frontiers in microbiology (08-01-2020)“…Infections caused by antibiotic-resistant are a threat to human and animal health globally. Phage therapy has made great progress for the treatment of…”
Get full text
Journal Article -
5
An antisense intragenic lncRNA SEAIRa mediates transcriptional and epigenetic repression of SERRATE in Arabidopsis
Published in Proceedings of the National Academy of Sciences - PNAS (07-03-2023)“…SERRATE (SE) is a core protein for microRNA (miRNA) biogenesis as well as for mRNA alternative splicing. Investigating the regulatory mechanism of expression…”
Get full text
Journal Article -
6
SYNCRIP, a new player in pri-let-7a processing
Published in RNA (Cambridge) (01-03-2020)“…microRNAs (miRNAs), a class of small and endogenous molecules that control gene expression, are broadly involved in biological processes. Although a number of…”
Get full text
Journal Article -
7
Capture of regulatory factors via CRISPR–dCas9 for mechanistic analysis of fine-tuned SERRATE expression in Arabidopsis
Published in Nature plants (01-01-2024)“…SERRATE (SE) plays an important role in many biological processes and under biotic stress resistance. However, little about the control of SE has been…”
Get full text
Journal Article