Search Results - "Yuan, Yun Fei"

RALYL increases hepatocellular carcinoma stemness by sustaining the mRNA stability of TGF-β2 by Wang, Xia, Wang, Jin, Tsui, Yu-Man, Shi, Chaoran, Wang, Ying, Zhang, Xin, Yan, Qian, Chen, Miao, Jiang, Chen, Yuan, Yun-Fei, Wong, Chun-Ming, Liu, Ming, Feng, Zeng-yu, Chen, Honglin, Ng, Irene Oi Lin, Jiang, Lingxi, Guan, Xin-Yuan

“…Growing evidences suggest that cancer stem cells exhibit many molecular characteristics and phenotypes similar to their ancestral progenitor cells. In the…”
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Octamer 4/microRNA‐1246 signaling axis drives Wnt/β‐catenin activation in liver cancer stem cells by Chai, Stella, Ng, Kai‐Yu, Tong, Man, Lau, Eunice Y., Lee, Terence K., Chan, Kwok Wah, Yuan, Yun‐Fei, Cheung, Tan‐To, Cheung, Siu‐Tim, Wang, Xiao‐Qi, Wong, Nathalie, Lo, Chung‐Mau, Man, Kwan, Guan, Xin‐Yuan, Ma, Stephanie

“…Wnt/β‐catenin signaling is activated in CD133 liver cancer stem cells (CSCs), a subset of cells known to be a root of tumor recurrence and therapy resistance…”
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Calcium‐binding protein 39 promotes hepatocellular carcinoma growth and metastasis by activating extracellular signal‐regulated kinase signaling pathway by Jiang, Lingxi, Yan, Qian, Fang, Shuo, Liu, Ming, Li, Yan, Yuan, Yun‐Fei, Li, Yan, Zhu, Yinghui, Qi, Jiali, Yang, Xiaodong, Kwong, Dora Lai Wan, Guan, Xin‐Yuan

“…Calcium‐binding protein (CAB39) is a key regulator of a group of sterile 20 kinases. Here, we report that CAB39 was frequently up‐regulated in hepatocellular…”
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Interleukin 17A promotes hepatocellular carcinoma metastasis via NF-kB induced matrix metalloproteinases 2 and 9 expression by Li, Jian, Lau, George Ka-Kit, Chen, Leilei, Dong, Sui-sui, Lan, Hui-Yao, Huang, Xiao-Ru, Li, Yan, Luk, John M, Yuan, Yun-Fei, Guan, Xin-yuan

“…IL-17A is a pro-inflammatory cytokine that plays important role in inflammatory disease pathology and tumor microenvironment. The aim of this study is to…”
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PARP inhibitor Olaparib overcomes Sorafenib resistance through reshaping the pluripotent transcriptome in hepatocellular carcinoma by Yang, Xiao-Dong, Kong, Fan-En, Qi, Ling, Lin, Jia-Xin, Yan, Qian, Loong, Jane Ho Chun, Xi, Shao-Yan, Zhao, Yue, Zhang, Yan, Yuan, Yun-Fei, Ma, Ning-Fang, Ma, Stephanie, Guan, Xin-Yuan, Liu, Ming

“…Hepatocellular carcinoma (HCC) is one of the most common human malignancies worldwide with very poor prognosis. Resistance to targeted therapeutic drugs such…”
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Lidocaine Induces Apoptosis and Suppresses Tumor Growth in Human Hepatocellular Carcinoma Cells In Vitro and in a Xenograft Model In Vivo by Xing, Wei, Chen, Dong-Tai, Pan, Jia-Hao, Chen, Yong-Hua, Yan, Yan, Li, Qiang, Xue, Rui-Feng, Yuan, Yun-Fei, Zeng, Wei-An

“…BACKGROUND:Recent epidemiologic studies have focused on the potential beneficial effects of regional anesthetics, and the differences in cancer prognosis may…”
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PGC7 promotes tumor oncogenic dedifferentiation through remodeling DNA methylation pattern for key developmental transcription factors by Yan, Qian, Zhang, Yu, Fang, Xiaona, Liu, Beilei, Wong, Tin Lok, Gong, Lanqi, Liu, Shan, Yu, Dandan, Liu, Ming, Jiang, Lingxi, Wang, Xia, Wei, Ting, Jia, Yongxu, Li, Lei, Sun, Liangzhan, Tang, Ying, Zhou, Ningning, Yuan, Yun-Fei, Li, Yan, Ma, Stephanie, Guan, Xin-Yuan

“…Poorly differentiated tumors usually exhibit phenotypes similar to that of their developmental precursor cells. Tumor cells that acquire the lineage progenitor…”
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ANGPTL1 Interacts with Integrin α1β1 to Suppress HCC Angiogenesis and Metastasis by Inhibiting JAK2/STAT3 Signaling by Yan, Qian, Jiang, Lingxi, Liu, Ming, Yu, Dandan, Zhang, Yu, Li, Yan, Fang, Shuo, Li, Yan, Zhu, Ying-Hui, Yuan, Yun-Fei, Guan, Xin-Yuan

“…Downregulation of tumor suppressor signaling plays an important role in the pathogenesis of hepatocellular carcinoma (HCC). Here, we report that downregulation…”
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A disrupted RNA editing balance mediated by ADARs (Adenosine DeAminases that act on RNA) in human hepatocellular carcinoma by Chan, Tim Hon Man, Lin, Chi Ho, Qi, Lihua, Fei, Jing, Li, Yan, Yong, Kol Jia, Liu, Ming, Song, Yangyang, Chow, Raymond Kwok Kei, Ng, Vanessa Hui En, Yuan, Yun-Fei, Tenen, Daniel G, Guan, Xin-Yuan, Chen, Leilei

“…Hepatocellular carcinoma (HCC) is a heterogeneous tumour displaying a complex variety of genetic and epigenetic changes. In human cancers, aberrant…”
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Maelstrom promotes hepatocellular carcinoma metastasis by inducing epithelial‐mesenchymal transition by way of Akt/GSK‐3β/Snail signaling by Liu, Lulu, Dai, Yongdong, Chen, Jinna, Zeng, Tingting, Li, Yan, Chen, Leilei, Zhu, Ying‐Hui, Li, Jiangchao, Li, Yan, Ma, Stephanie, Xie, Dan, Yuan, Yun‐Fei, Guan, Xin‐Yuan

“…Amplification of 1q is one of the most frequent chromosomal alterations in human hepatocellular carcinoma (HCC). In this study we identified and characterized…”
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SPOCK1 Is Regulated by CHD1L and Blocks Apoptosis and Promotes HCC Cell Invasiveness and Metastasis in Mice by Li, Yan, Chen, Leilei, Chan, Tim Hon Man, Liu, Ming, Kong, Kar–Lok, Qiu, Ji–Liang, Yuan, Yun–Fei, Guan, Xin–Yuan

“…Background & Aims Chromodomain helicase/adenosine triphosphatase DNA binding protein 1-like (CHD1L) is an SNF2-like transcription factor involved in the…”
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Lymphoid enhancer-binding factor-1 promotes stemness and poor differentiation of hepatocellular carcinoma by directly activating the NOTCH pathway by Fang, Shuo, Liu, Ming, Li, Lei, Zhang, Fei-Fei, Li, Yun, Yan, Qian, Cui, Yu-Zhu, Zhu, Ying-Hui, Yuan, Yun-Fei, Guan, Xin-Yuan

“…The poorly differentiated hepatocellular carcinoma (HCC) cells are usually characterized by immature hepatic progenitor cell-like properties, such as enhanced…”
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Interleukin 23 promotes hepatocellular carcinoma metastasis via NF-kappa B induced matrix metalloproteinase 9 expression by Li, Jian, Lau, George, Chen, Leilei, Yuan, Yun-Fei, Huang, Jun, Luk, John M, Xie, Dan, Guan, Xin-Yuan

“…Hepatocellular carcinoma (HCC) is one of the most popular cancers in the world with poor prognosis, which often develops from chronic liver inflammatory…”
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The Immunoscore system predicts prognosis after liver metastasectomy in colorectal cancer liver metastases by Wang, Yun, Lin, Hao-cheng, Huang, Ma-yan, Shao, Qiong, Wang, Zhi-qiang, Wang, Feng-hua, Yuan, Yun-fei, Li, Bin-kui, Wang, De-shen, Ding, Pei-rong, Chen, Gong, Wu, Xiao-jun, Lu, Zhen-hai, Li, Li-ren, Pan, Zhi-zhong, Sun, Peng, Yan, Shu-mei, Wan, De-sen, Xu, Rui-hua, Li, Yu-hong

“…Background The Immunoscore was initially established to evaluate the prognosis of stage I/II/III colorectal cancer patients. However, the feasibility of the…”
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Cetuximab plus FOLFOXIRI versus cetuximab plus FOLFOX as conversion regimen in RAS/BRAF wild-type patients with initially unresectable colorectal liver metastases (TRICE trial): A randomized controlled trial by Wang, De-Shen, Ren, Chao, Li, Shan-Shan, Fong, William Pat, Wu, Xiao-Jun, Xiao, Jian, Li, Bin-Kui, Zheng, Yun, Ding, Pei-Rong, Chen, Gong, Qiu, Miao-Zhen, Wang, Zhi-Qiang, Wang, Feng-Hua, Luo, Hui-Yan, Wang, Feng, Wang, Xiao-Zhong, Wang, Ling-Yun, Xie, De-Jin, Chen, Tao, Li, Li-Ren, Lu, Zhen-Hai, Zhai, Xiao-Hui, Liu, Tian-Shu, Yuan, Ying, Chen, Jia-Qi, Tan, Qiong, Pan, Zhi-Zhong, Wan, De-Sen, Zhang, Rong, Yuan, Yun-Fei, Xu, Rui-Hua, Li, Yu-Hong

“…It remains unclear whether intensification of the chemotherapy backbone in tandem with an anti-EGFR can confer superior clinical outcomes in a cohort of…”
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Genome-wide mutational signatures of aristolochic acid and its application as a screening tool by Poon, Song Ling, Pang, See-Tong, McPherson, John R, Yu, Willie, Huang, Kie Kyon, Guan, Peiyong, Weng, Wen-Hui, Siew, Ee Yan, Liu, Yujing, Heng, Hong Lee, Chong, Soo Ching, Gan, Anna, Tay, Su Ting, Lim, Weng Khong, Cutcutache, Ioana, Huang, Dachuan, Ler, Lian Dee, Nairismägi, Maarja-Liisa, Lee, Ming Hui, Chang, Ying-Hsu, Yu, Kai-Jie, Chan-On, Waraporn, Li, Bin-Kui, Yuan, Yun-Fei, Qian, Chao-Nan, Ng, Kwai-Fong, Wu, Ching-Fang, Hsu, Cheng-Lung, Bunte, Ralph M, Stratton, Michael R, Futreal, P Andrew, Sung, Wing-Kin, Chuang, Cheng-Keng, Ong, Choon Kiat, Rozen, Steven G, Tan, Patrick, Teh, Bin Tean

“…Aristolochic acid (AA), a natural product of Aristolochia plants found in herbal remedies and health supplements, is a group 1 carcinogen that can cause…”
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LncRNA Lnc‐APUE is Repressed by HNF4α and Promotes G1/S Phase Transition and Tumor Growth by Regulating MiR‐20b/E2F1 Axis by Li, Song‐Yang, Zhu, Ying, Li, Ruo‐Nan, Huang, Jia‐Hui, You, Kai, Yuan, Yun‐Fei, Zhuang, Shi‐Mei

“…Many long noncoding RNAs (lncRNAs) have been annotated, but their functions remain unknown. The authors found a novel lnc‐APUE (lncRNA accelerating…”
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PRMT6 Regulates RAS/RAF Binding and MEK/ERK-Mediated Cancer Stemness Activities in Hepatocellular Carcinoma through CRAF Methylation by Chan, Lok Hei, Zhou, Lei, Ng, Kai Yu, Wong, Tin Lok, Lee, Terence K., Sharma, Rakesh, Loong, Jane H., Ching, Yick Pang, Yuan, Yun-Fei, Xie, Dan, Lo, Chung Mau, Man, Kwan, Artegiani, Benedetta, Clevers, Hans, Yan, Helen H., Leung, Suet Yi, Richard, Stéphane, Guan, Xin-Yuan, Huen, Michael S.Y., Ma, Stephanie

“…Arginine methylation is a post-translational modification that plays pivotal roles in signal transduction and gene transcription during cell fate…”
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Systemic delivery of microRNA-101 potently inhibits hepatocellular carcinoma in vivo by repressing multiple targets by Zheng, Fang, Liao, Yi-Ji, Cai, Mu-Yan, Liu, Tian-Hao, Chen, Shu-Peng, Wu, Pei-Hong, Wu, Long, Bian, Xiu-Wu, Guan, Xin-Yuan, Zeng, Yi-Xin, Yuan, Yun-Fei, Kung, Hsiang-Fu, Xie, Dan

“…Targeted therapy based on adjustment of microRNA (miRNA)s activity takes great promise due to the ability of these small RNAs to modulate cellular behavior…”
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Dynamic monitoring of circulating tumor DNA to predict prognosis and efficacy of adjuvant chemotherapy after resection of colorectal liver metastases by Wang, De-Shen, Yang, Hui, Liu, Xiao-Yun, Chen, Zhi-Gang, Wang, Yun, Fong, William Pat, Hu, Ming-Tao, Zheng, Yuan-Chao, Zheng, Yun, Li, Bin-Kui, Yuan, Yun-Fei, Chen, Gong, Pan, Zhi-Zhong, Song, Lele, Li, Yu-Hong, Xu, Rui-Hua

“…Rationale: Hepatectomy and adjuvant chemotherapy after resection of colorectal liver metastases (CRLM) may improve survival, however, patients which may…”
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