Search Results - "Yuan, Jason X J"

SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2 by Lei, Yuyang, Zhang, Jiao, Schiavon, Cara R., He, Ming, Chen, Lili, Shen, Hui, Zhang, Yichi, Yin, Qian, Cho, Yoshitake, Andrade, Leonardo, Shadel, Gerald S., Hepokoski, Mark, Lei, Ting, Wang, Hongliang, Zhang, Jin, Yuan, Jason X.-J., Malhotra, Atul, Manor, Uri, Wang, Shengpeng, Yuan, Zu-Yi, Shyy, John Y-J.

Get full text

mTOR Signaling in Pulmonary Vascular Disease: Pathogenic Role and Therapeutic Target by Babicheva, Aleksandra, Makino, Ayako, Yuan, Jason X-J

“…Pulmonary arterial hypertension (PAH) is a progressive and fatal disease without a cure. The exact pathogenic mechanisms of PAH are complex and poorly…”
Get full text

MDM2-Mediated Ubiquitination of Angiotensin-Converting Enzyme 2 Contributes to the Development of Pulmonary Arterial Hypertension by Shen, Hui, Zhang, Jiao, Wang, Chen, Jain, Pritesh P., Xiong, Mingmei, Shi, Xinxing, Lei, Yuyang, Chen, Shanshan, Yin, Qian, Thistlethwaite, Patricia A., Wang, Jian, Gong, Kaizheng, Yuan, Zu-Yi, Yuan, Jason X.-J., Shyy, John Y.-J.

“…BACKGROUND:Angiotensin-converting enzyme 2 (ACE2) converts angiotensin II, a potent vasoconstrictor, to angiotensin-(1–7) and is also a membrane protein that…”
Get full text

PFKFB3-mediated endothelial glycolysis promotes pulmonary hypertension by Cao, Yapeng, Zhang, Xiaoyu, Wang, Lina, Yang, Qiuhua, Ma, Qian, Xu, Jiean, Wang, Jingjing, Kovacs, Laszlo, Ayon, Ramon J., Liu, Zhiping, Zhang, Min, Zhou, Yaqi, Zeng, Xianqiu, Xu, Yiming, Wang, Yong, Fulton, David J., Weintraub, Neal L., Lucas, Rudolf, Dong, Zheng, Yuan, Jason X.-J., Sullivan, Jennifer C., Meadows, Louise, Barman, Scott A., Wu, Chaodong, Quan, Junmin, Hong, Mei, Su, Yunchao, Huo, Yuqing

“…Increased glycolysis in the lung vasculature has been connected to the development of pulmonary hypertension (PH). We therefore investigated whether glycolytic…”
Get full text

Cellular and Molecular Basis of Pulmonary Arterial Hypertension by Morrell, Nicholas W., MA, MD, Adnot, Serge, MD, PhD, Archer, Stephen L., MD, Dupuis, Jocelyn, MD, PhD, Lloyd Jones, Peter, PhD, MacLean, Margaret R., PhD, McMurtry, Ivan F., PhD, Stenmark, Kurt R., MD, Thistlethwaite, Patricia A., MD, PhD, Weissmann, Norbert, PhD, Yuan, Jason X.-J., MD, PhD, Weir, E. Kenneth, MD

“…Pulmonary arterial hypertension (PAH) is caused by functional and structural changes in the pulmonary vasculature, leading to increased pulmonary vascular…”
Get full text

Halofuginone, a promising drug for treatment of pulmonary hypertension by Jain, Pritesh P., Zhao, Tengteng, Xiong, Mingmei, Song, Shanshan, Lai, Ning, Zheng, Qiuyu, Chen, Jiyuan, Carr, Shane G., Babicheva, Aleksandra, Izadi, Amin, Rodriguez, Marisela, Rahimi, Shamin, Balistrieri, Francesca, Rahimi, Shayan, Simonson, Tatum, Valdez‐Jasso, Daniela, Thistlethwaite, Patricia A., Shyy, John Y.‐J., Wang, Jian, Makino, Ayako, Yuan, Jason X.‐J.

“…Background and Purpose Halofuginone is a febrifugine derivative originally isolated from Chinese traditional herb Chang Shan that exhibits anti‐hypertrophic,…”
Get full text

Inflammation, Growth Factors, and Pulmonary Vascular Remodeling by Hassoun, Paul M., MD, Mouthon, Luc, MD, PhD, Barberà, Joan A., MD, Eddahibi, Saadia, PhD, Flores, Sonia C., PhD, Grimminger, Friedrich, MD, PhD, Jones, Peter Lloyd, PhD, Maitland, Michael L., MD, PhD, Michelakis, Evangelos D., MD, Morrell, Nicholas W., MA, MD, Newman, John H., MD, Rabinovitch, Marlene, MD, Schermuly, Ralph, PhD, Stenmark, Kurt R., MD, Voelkel, Norbert F., MD, Yuan, Jason X.-J., MD, PhD, Humbert, Marc, MD, PhD

“…Inflammatory processes are prominent in various types of human and experimental pulmonary hypertension (PH) and are increasingly recognized as major pathogenic…”
Get full text

Endothelial Notch1 in Pulmonary Hypertension: Friend or Foe? by Babicheva, Aleksandra, Yuan, Jason X.-J

Get full text

Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases by Tsigelny, Igor F, Crews, Leslie, Desplats, Paula, Shaked, Gideon M, Sharikov, Yuriy, Mizuno, Hideya, Spencer, Brian, Rockenstein, Edward, Trejo, Margarita, Platoshyn, Oleksandr, Yuan, Jason X-J, Masliah, Eliezer

“…Misfolding and pathological aggregation of neuronal proteins has been proposed to play a critical role in the pathogenesis of neurodegenerative disorders…”
Get full text

Nicotinamide Phosphoribosyltransferase Promotes Pulmonary Vascular Remodeling and Is a Therapeutic Target in Pulmonary Arterial Hypertension by Chen, Jiwang, Sysol, Justin R, Singla, Sunit, Zhao, Shuangping, Yamamura, Aya, Valdez-Jasso, Daniela, Abbasi, Taimur, Shioura, Krystyna M, Sahni, Sakshi, Reddy, Vamsi, Sridhar, Arvind, Gao, Hui, Torres, Jaime, Camp, Sara M, Tang, Haiyang, Qing Ye, Shui, Comhair, Suzy, Dweik, Raed, Hassoun, Paul, Yuan, Jason X.-J, Garcia, Joe G.N, Machado, Roberto F

“…BACKGROUND:Pulmonary arterial hypertension is a severe and progressive disease, a hallmark of which is pulmonary vascular remodeling. Nicotinamide…”
Get full text

Upregulated expression of STIM2, TRPC6, and Orai2 contributes to the transition of pulmonary arterial smooth muscle cells from a contractile to proliferative phenotype by Fernandez, Ruby A, Wan, Jun, Song, Shanshan, Smith, Kimberly A, Gu, Yali, Tauseef, Mohammad, Tang, Haiyang, Makino, Ayako, Mehta, Dolly, Yuan, Jason X-J

“…Pulmonary arterial hypertension (PAH) is a progressive disease that, if left untreated, eventually leads to right heart failure and death. Elevated pulmonary…”
Get more information

Tetramethylpyrazine: A promising drug for the treatment of pulmonary hypertension by Chen, Yuqin, Lu, Wenju, Yang, Kai, Duan, Xin, Li, Mengxi, Chen, Xiuqing, Zhang, Jie, Kuang, Meidan, Liu, Shiyun, Wu, Xiongting, Zou, Guofa, Liu, Chunli, Hong, Cheng, He, Wenjun, Liao, Jing, Hou, Chi, Zhang, Zhe, Zheng, Qiuyu, Chen, Jiyuan, Zhang, Nuofu, Tang, Haiyang, Vanderpool, Rebecca R., Desai, Ankit A., Rischard, Franz, Black, Stephen M., Garcia, Joe G.N., Makino, Ayako, Yuan, Jason X.‐J., Zhong, Nanshan, Wang, Jian

“…Background and Purpose Tetramethylpyrazine (TMP) was originally isolated from the traditional Chinese herb ligusticum and the fermented Japanese food natto and…”
Get full text

STIM2 (Stromal Interaction Molecule 2)–Mediated Increase in Resting Cytosolic Free Ca2+ Concentration Stimulates PASMC Proliferation in Pulmonary Arterial Hypertension by Song, Shanshan, Carr, Shane G, McDermott, Kimberly M, Rodriguez, Marisela, Babicheva, Aleksandra, Balistrieri, Angela, Ayon, Ramon J, Wang, Jian, Makino, Ayako, Yuan, Jason X.-J

“…An increase in cytosolic free Ca concentration ([Ca]cyt) in pulmonary artery smooth muscle cells (PASMCs) triggers pulmonary vasoconstriction and stimulates…”
Get full text

Endothelial dysfunction in pulmonary arterial hypertension: an evolving landscape (2017 Grover Conference Series) by Ranchoux, Benoît, Harvey, Lloyd D., Ayon, Ramon J., Babicheva, Aleksandra, Bonnet, Sebastien, Chan, Stephen Y., Yuan, Jason X.-J., Perez, Vinicio de Jesus

“…Endothelial dysfunction is a major player in the development and progression of vascular pathology in pulmonary arterial hypertension (PAH), a disease…”
Get full text

Differentially expressed plasma microRNAs and the potential regulatory function of Let-7b in chronic thromboembolic pulmonary hypertension by Guo, Lijuan, Yang, Yuanhua, Liu, Jie, Wang, Lei, Li, Jifeng, Wang, Ying, Liu, Yan, Gu, Song, Gan, Huili, Cai, Jun, Yuan, Jason X-J, Wang, Jun, Wang, Chen

“…Chronic thromboembolic pulmonary hypertension (CTEPH) is a progressive disease characterized by misguided thrombolysis and remodeling of pulmonary arteries…”
Get full text

Persistent eNOS activation secondary to caveolin-1 deficiency induces pulmonary hypertension in mice and humans through PKG nitration by Zhao, You-Yang, Zhao, Yidan D, Mirza, Muhammad K, Huang, Julia H, Potula, Hari-Hara S K, Vogel, Steven M, Brovkovych, Viktor, Yuan, Jason X-J, Wharton, John, Malik, Asrar B

“…Pulmonary hypertension (PH) is an unremitting disease defined by a progressive increase in pulmonary vascular resistance leading to right-sided heart failure…”
Get full text

Airway delivery of Streptococcus salivarius is sufficient to induce experimental pulmonary hypertension in rats by Zhang, Chenting, Zhang, Tingting, Xing, Yue, Lu, Wenju, Chen, Jiyuan, Luo, Xiaoyun, Wu, Xuefen, Liu, Shiyun, Chen, Lishi, Zhang, Zizhou, Zhou, Dansha, Lin, Ziying, Chen, Yuqin, Xiong, Mingmei, Yuan, Jason X.‐J., Yang, Kai, Wang, Jian

“…Background and Purpose The causal relationship between altered host microbiome composition, especially the respiratory tract microbiome, and the occurrence of…”
Get full text

KCNK3 Channel: A New Player in the Field of Pulmonary Vascular Disease by Babicheva, Aleksandra, Zhao, Tengteng, Yuan, Jason X.-J

Get full text

Mechanosensitive channel Piezo1 is required for pulmonary artery smooth muscle cell proliferation by Chen, Jiyuan, Rodriguez, Marisela, Miao, Jinrui, Liao, Jing, Jain, Pritesh P, Zhao, Manjia, Zhao, Tengteng, Babicheva, Aleksandra, Wang, Ziyi, Parmisano, Sophia, Powers, Ryan, Matti, Moreen, Paquin, Cole, Soroureddin, Zahra, Shyy, John Y-J, Thistlethwaite, Patricia A, Makino, Ayako, Wang, Jian, Yuan, Jason X-J

“…Concentric pulmonary vascular wall thickening due partially to increased pulmonary artery (PA) smooth muscle cell (PASMC) proliferation contributes to…”
Get more information

The sphingosine kinase 1/sphingosine-1-phosphate pathway in pulmonary arterial hypertension by Chen, Jiwang, Tang, Haiyang, Sysol, Justin R, Moreno-Vinasco, Liliana, Shioura, Krystyna M, Chen, Tianji, Gorshkova, Irina, Wang, Lichun, Huang, Long Shuang, Usatyuk, Peter V, Sammani, Saad, Zhou, Guofei, Raj, J Usha, Garcia, Joe G N, Berdyshev, Evgeny, Yuan, Jason X-J, Natarajan, Viswanathan, Machado, Roberto F

“…Sphingosine kinases (SphKs) 1 and 2 regulate the synthesis of the bioactive sphingolipid sphingosine-1-phosphate (S1P), an important lipid mediator that…”
Get full text