Search Results - "Yuan, Jason"

SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2 by Lei, Yuyang, Zhang, Jiao, Schiavon, Cara R., He, Ming, Chen, Lili, Shen, Hui, Zhang, Yichi, Yin, Qian, Cho, Yoshitake, Andrade, Leonardo, Shadel, Gerald S., Hepokoski, Mark, Lei, Ting, Wang, Hongliang, Zhang, Jin, Yuan, Jason X.-J., Malhotra, Atul, Manor, Uri, Wang, Shengpeng, Yuan, Zu-Yi, Shyy, John Y-J.

Get full text

MDM2-Mediated Ubiquitination of Angiotensin-Converting Enzyme 2 Contributes to the Development of Pulmonary Arterial Hypertension by Shen, Hui, Zhang, Jiao, Wang, Chen, Jain, Pritesh P., Xiong, Mingmei, Shi, Xinxing, Lei, Yuyang, Chen, Shanshan, Yin, Qian, Thistlethwaite, Patricia A., Wang, Jian, Gong, Kaizheng, Yuan, Zu-Yi, Yuan, Jason X.-J., Shyy, John Y.-J.

“…BACKGROUND:Angiotensin-converting enzyme 2 (ACE2) converts angiotensin II, a potent vasoconstrictor, to angiotensin-(1–7) and is also a membrane protein that…”
Get full text

mTOR Signaling in Pulmonary Vascular Disease: Pathogenic Role and Therapeutic Target by Babicheva, Aleksandra, Makino, Ayako, Yuan, Jason X-J

“…Pulmonary arterial hypertension (PAH) is a progressive and fatal disease without a cure. The exact pathogenic mechanisms of PAH are complex and poorly…”
Get full text

Cellular and Molecular Basis of Pulmonary Arterial Hypertension by Morrell, Nicholas W., MA, MD, Adnot, Serge, MD, PhD, Archer, Stephen L., MD, Dupuis, Jocelyn, MD, PhD, Lloyd Jones, Peter, PhD, MacLean, Margaret R., PhD, McMurtry, Ivan F., PhD, Stenmark, Kurt R., MD, Thistlethwaite, Patricia A., MD, PhD, Weissmann, Norbert, PhD, Yuan, Jason X.-J., MD, PhD, Weir, E. Kenneth, MD

“…Pulmonary arterial hypertension (PAH) is caused by functional and structural changes in the pulmonary vasculature, leading to increased pulmonary vascular…”
Get full text

PFKFB3-mediated endothelial glycolysis promotes pulmonary hypertension by Cao, Yapeng, Zhang, Xiaoyu, Wang, Lina, Yang, Qiuhua, Ma, Qian, Xu, Jiean, Wang, Jingjing, Kovacs, Laszlo, Ayon, Ramon J., Liu, Zhiping, Zhang, Min, Zhou, Yaqi, Zeng, Xianqiu, Xu, Yiming, Wang, Yong, Fulton, David J., Weintraub, Neal L., Lucas, Rudolf, Dong, Zheng, Yuan, Jason X.-J., Sullivan, Jennifer C., Meadows, Louise, Barman, Scott A., Wu, Chaodong, Quan, Junmin, Hong, Mei, Su, Yunchao, Huo, Yuqing

“…Increased glycolysis in the lung vasculature has been connected to the development of pulmonary hypertension (PH). We therefore investigated whether glycolytic…”
Get full text

Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases by Tsigelny, Igor F, Crews, Leslie, Desplats, Paula, Shaked, Gideon M, Sharikov, Yuriy, Mizuno, Hideya, Spencer, Brian, Rockenstein, Edward, Trejo, Margarita, Platoshyn, Oleksandr, Yuan, Jason X-J, Masliah, Eliezer

“…Misfolding and pathological aggregation of neuronal proteins has been proposed to play a critical role in the pathogenesis of neurodegenerative disorders…”
Get full text

Risk factors and basic mechanisms of chronic thromboembolic pulmonary hypertension: a current understanding by LANG, Irene M, PESAVENTO, Raffaele, BONDERMAN, Diana, YUAN, Jason X-J

“…All available evidence today indicates that chronic thromboembolic pulmonary hypertension (CTEPH) is primarily caused by venous thromboembolism, as opposed to…”
Get full text

Targeting ATP-Sensitive K + Channels to Treat Pulmonary Hypertension by Breen, Ellen, Yuan, Jason X-J

“…Pulmonary arterial hypertension (PAH) with other forms of precapillary pulmonary hypertension (PH) is characterized by increases in pulmonary vascular…”
Get full text

Endothelial Notch1 in Pulmonary Hypertension: Friend or Foe? by Babicheva, Aleksandra, Yuan, Jason X.-J

Get full text

Endothelial HIF-2α contributes to severe pulmonary hypertension due to endothelial-to-mesenchymal transition by Tang, Haiyang, Babicheva, Aleksandra, McDermott, Kimberly M, Gu, Yali, Ayon, Ramon J, Song, Shanshan, Wang, Ziyi, Gupta, Akash, Zhou, Tong, Sun, Xutong, Dash, Swetaleena, Wang, Zilu, Balistrieri, Angela, Zheng, Qiuyu, Cordery, Arlette G, Desai, Ankit A, Rischard, Franz, Khalpey, Zain, Wang, Jian, Black, Stephen M, Garcia, Joe G N, Makino, Ayako, Yuan, Jason X-J

“…Pulmonary vascular remodeling characterized by concentric wall thickening and intraluminal obliteration is a major contributor to the elevated pulmonary…”
Get more information

Differentially expressed plasma microRNAs and the potential regulatory function of Let-7b in chronic thromboembolic pulmonary hypertension by Guo, Lijuan, Yang, Yuanhua, Liu, Jie, Wang, Lei, Li, Jifeng, Wang, Ying, Liu, Yan, Gu, Song, Gan, Huili, Cai, Jun, Yuan, Jason X-J, Wang, Jun, Wang, Chen

“…Chronic thromboembolic pulmonary hypertension (CTEPH) is a progressive disease characterized by misguided thrombolysis and remodeling of pulmonary arteries…”
Get full text

Halofuginone, a promising drug for treatment of pulmonary hypertension by Jain, Pritesh P., Zhao, Tengteng, Xiong, Mingmei, Song, Shanshan, Lai, Ning, Zheng, Qiuyu, Chen, Jiyuan, Carr, Shane G., Babicheva, Aleksandra, Izadi, Amin, Rodriguez, Marisela, Rahimi, Shamin, Balistrieri, Francesca, Rahimi, Shayan, Simonson, Tatum, Valdez‐Jasso, Daniela, Thistlethwaite, Patricia A., Shyy, John Y.‐J., Wang, Jian, Makino, Ayako, Yuan, Jason X.‐J.

“…Background and Purpose Halofuginone is a febrifugine derivative originally isolated from Chinese traditional herb Chang Shan that exhibits anti‐hypertrophic,…”
Get full text

Upregulation of Piezo1 (Piezo Type Mechanosensitive Ion Channel Component 1) Enhances the Intracellular Free Calcium in Pulmonary Arterial Smooth Muscle Cells From Idiopathic Pulmonary Arterial Hypertension Patients by Liao, Jing, Lu, Wenju, Chen, Yuqin, Duan, Xin, Zhang, Chenting, Luo, Xiaoyun, Lin, Ziying, Chen, Jiyuan, Liu, Shiyun, Yan, Han, Chen, Yilin, Feng, Huazhuo, Zhou, Dansha, Chen, Xu, Zhang, Zizhou, Yang, Qifeng, Liu, Xinyi, Tang, Haiyang, Li, Jing, Makino, Ayako, Yuan, Jason X.-J., Zhong, Nanshan, Yang, Kai, Wang, Jian

“…Emerging studies have reported the mechanosensitive Piezo1 (piezo type mechanosensitive ion channel component 1) plays essential roles in regulating the…”
Get full text

Inflammation, Growth Factors, and Pulmonary Vascular Remodeling by Hassoun, Paul M., MD, Mouthon, Luc, MD, PhD, Barberà, Joan A., MD, Eddahibi, Saadia, PhD, Flores, Sonia C., PhD, Grimminger, Friedrich, MD, PhD, Jones, Peter Lloyd, PhD, Maitland, Michael L., MD, PhD, Michelakis, Evangelos D., MD, Morrell, Nicholas W., MA, MD, Newman, John H., MD, Rabinovitch, Marlene, MD, Schermuly, Ralph, PhD, Stenmark, Kurt R., MD, Voelkel, Norbert F., MD, Yuan, Jason X.-J., MD, PhD, Humbert, Marc, MD, PhD

“…Inflammatory processes are prominent in various types of human and experimental pulmonary hypertension (PH) and are increasingly recognized as major pathogenic…”
Get full text

Pathophysiology and pathogenic mechanisms of pulmonary hypertension: role of membrane receptors, ion channels, and Ca2+ signaling by Balistrieri, Angela, Makino, Ayako, Yuan, Jason X-J

“…The pulmonary circulation is a low-resistance, low-pressure, and high-compliance system that allows the lungs to receive the entire cardiac output. Pulmonary…”
Get full text

NEDD9, a Hypoxia-upregulated Mediator for Pathogenic Platelet-endothelial Cell Interaction in Pulmonary Hypertension by Wang, Jian, Yang, Kai, Yuan, Jason X-J

“…Wang et al discuss the study by Alba and colleagues on a novel mechanism in which hypoxia induces an HIF-1beta-dependent upregulation of the NEDD9 (neural…”
Get full text

Revisiting the Role of KCNA5 in Pulmonary Arterial Hypertension by Ayon, Ramon J, Yuan, Jason X-J

“…Ayon and Yuan discuss the study by A. Vera-Zambrano and colleagues on nonsynonymous SNPs of KCNA5 found in patients with pulmonary arterial hypertension (PAH)…”
Get full text

Nicotinamide Phosphoribosyltransferase Promotes Pulmonary Vascular Remodeling and Is a Therapeutic Target in Pulmonary Arterial Hypertension by Chen, Jiwang, Sysol, Justin R, Singla, Sunit, Zhao, Shuangping, Yamamura, Aya, Valdez-Jasso, Daniela, Abbasi, Taimur, Shioura, Krystyna M, Sahni, Sakshi, Reddy, Vamsi, Sridhar, Arvind, Gao, Hui, Torres, Jaime, Camp, Sara M, Tang, Haiyang, Qing Ye, Shui, Comhair, Suzy, Dweik, Raed, Hassoun, Paul, Yuan, Jason X.-J, Garcia, Joe G.N, Machado, Roberto F

“…BACKGROUND:Pulmonary arterial hypertension is a severe and progressive disease, a hallmark of which is pulmonary vascular remodeling. Nicotinamide…”
Get full text

SGLT inhibitors attenuate NO-dependent vascular relaxation in the pulmonary artery but not in the coronary artery by Han, Ying, Cho, Young-Eun, Ayon, Ramon, Guo, Rui, Youssef, Katia D, Pan, Minglin, Dai, Anzhi, Yuan, Jason X-J, Makino, Ayako

“…Inhibitors of sodium-glucose cotransporter (SGLT)2 are a new class of oral drugs for type 2 diabetic patients that reduce plasma glucose levels by inhibiting…”
Get more information

Metabolic Changes Precede the Development of Pulmonary Hypertension in the Monocrotaline Exposed Rat Lung by Rafikova, Olga, Meadows, Mary L, Kinchen, Jason M, Mohney, Robert P, Maltepe, Emin, Desai, Ankit A, Yuan, Jason X-J, Garcia, Joe G N, Fineman, Jeffrey R, Rafikov, Ruslan, Black, Stephen M

“…There is increasing interest in the potential for metabolic profiling to evaluate the progression of pulmonary hypertension (PH). However, a detailed analysis…”
Get full text