Search Results - "Yuan, Huipin"

A Rational Strategy for Reducing On-Target Off-Tumor Effects of CD38-Chimeric Antigen Receptors by Affinity Optimization by Drent, Esther, Themeli, Maria, Poels, Renée, de Jong-Korlaar, Regina, Yuan, Huipin, de Bruijn, Joost, Martens, Anton C.M., Zweegman, Sonja, van de Donk, Niels W.C.J., Groen, Richard W.J., Lokhorst, Henk M., Mutis, Tuna

“…Chimeric antigen receptors (CARs) can effectively redirect cytotoxic T cells toward highly expressed surface antigens on tumor cells. The low expression of…”
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Osteoinductive ceramics as a synthetic alternative to autologous bone grafting by Yuan, Huipin, Fernandes, Hugo, Habibovic, Pamela, de Boer, Jan, Barradas, Ana M. C., de Ruiter, Ad, Walsh, William R., van Blitterswijk, Clemens A., de Bruijn, Joost D., Langer, Robert

“…Biomaterials can be endowed with biologically instructive properties by changing basic parameters such as elasticity and surface texture. However, translation…”
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The size of surface microstructures as an osteogenic factor in calcium phosphate ceramics by Zhang, Jingwei, Luo, Xiaoman, Barbieri, Davide, Barradas, Ana M.C., de Bruijn, Joost D., van Blitterswijk, Clemens A., Yuan, Huipin

“…[Display omitted] The microporosity of calcium phosphate (CaP) ceramics has been shown to have an essential role in osteoinduction by CaP ceramics after…”
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Liposomal clodronate inhibition of osteoclastogenesis and osteoinduction by submicrostructured beta-tricalcium phosphate by Davison, Noel L, Gamblin, Anne-Laure, Layrolle, Pierre, Yuan, Huipin, de Bruijn, Joost D, Barrère-de Groot, Florence

“…Abstract Bone graft substitutes such as calcium phosphates are subject to the innate inflammatory reaction, which may bear important consequences for bone…”
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CD38 as a therapeutic target for adult acute myeloid leukemia and T-cell acute lymphoblastic leukemia by Naik, Jyoti, Themeli, Maria, de Jong-Korlaar, Regina, Ruiter, Ruud W J, Poddighe, Pino J, Yuan, Huipin, de Bruijn, Joost D, Ossenkoppele, Gert J, Zweegman, Sonja, Smit, Linda, Mutis, Tuna, Martens, Anton C M, van de Donk, Niels W C J, Groen, Richard W J

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Osteoclast resorption of beta-tricalcium phosphate controlled by surface architecture by Davison, Noel L, ten Harkel, Bas, Schoenmaker, Ton, Luo, Xiaoman, Yuan, Huipin, Everts, Vincent, Barrère-de Groot, Florence, de Bruijn, Joost D

“…Abstract A resorbable bone graft substitute should mimic native bone in its capacity to support bone formation and be remodeled by osteoclasts (OCl) or other…”
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Strontium-containing apatite/polylactide composites enhance bone formation in osteopenic rabbits by Luo, Xiaoman, Barbieri, Davide, Duan, Rongquan, Yuan, Huipin, Bruijn, Joost D.

“…[Display omitted] Strontium (Sr) has been shown to favor bone formation and is used clinically to treat osteoporosis. We have previously reported that Sr…”
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The homing of bone marrow MSCs to non-osseous sites for ectopic bone formation induced by osteoinductive calcium phosphate by Song, Guodong, Habibovic, Pamela, Bao, Chongyun, Hu, Jing, van Blitterswijk, Clemens A, Yuan, Huipin, Chen, Wenchuan, Xu, Hockin H.K

“…Abstract Osteoinductive biomaterials are promising for bone repair. There is no direct proof that bone marrow mesenchymal stem cells (BMSCs) home to…”
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Pre-clinical evaluation of CD38 chimeric antigen receptor engineered T cells for the treatment of multiple myeloma by Drent, Esther, Groen, Richard W J, Noort, Willy A, Themeli, Maria, Lammerts van Bueren, Jeroen J, Parren, Paul W H I, Kuball, Jürgen, Sebestyen, Zsolt, Yuan, Huipin, de Bruijn, Joost, van de Donk, Niels W C J, Martens, Anton C M, Lokhorst, Henk M, Mutis, Tuna

“…Adoptive transfer of chimeric antigen receptor-transduced T cells is a promising strategy for cancer immunotherapy. The CD38 molecule, with its high expression…”
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Ectopic bone formation by aggregated mesenchymal stem cells from bone marrow and adipose tissue: A comparative study by Fennema, Eelco M., Tchang, Laurent A.H., Yuan, Huipin, Blitterswijk, Clemens A., Martin, Ivan, Scherberich, Arnaud, Boer, Jan

“…Tissue engineered constructs (TECs) based on spheroids of bone marrow mesenchymal stromal cells (BM‐MSCs) combined with calcium phosphate microparticles and…”
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A Mussel‐Inspired Conductive, Self‐Adhesive, and Self‐Healable Tough Hydrogel as Cell Stimulators and Implantable Bioelectronics by Han, Lu, Lu, Xiong, Wang, Menghao, Gan, Donglin, Deng, Weili, Wang, Kefeng, Fang, Liming, Liu, Kezhi, Chan, Chun Wai, Tang, Youhong, Weng, Lu‐Tao, Yuan, Huipin

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Non-canonical PRC1.1 Targets Active Genes Independent of H3K27me3 and Is Essential for Leukemogenesis by van den Boom, Vincent, Maat, Henny, Geugien, Marjan, Rodríguez López, Aida, Sotoca, Ana M., Jaques, Jennifer, Brouwers-Vos, Annet Z., Fusetti, Fabrizia, Groen, Richard W.J., Yuan, Huipin, Martens, Anton C.M., Stunnenberg, Hendrik G., Vellenga, Edo, Martens, Joost H.A., Schuringa, Jan Jacob

“…Polycomb proteins are classical regulators of stem cell self-renewal and cell lineage commitment and are frequently deregulated in cancer. Here, we find that…”
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Impact of pore size on the vascularization and osseointegration of ceramic bone substitutes in vivo by Klenke, Frank M., Liu, Yuelian, Yuan, Huipin, Hunziker, Ernst B., Siebenrock, Klaus A., Hofstetter, Willy

“…The repair of bone defects with biomaterials depends on a sufficient vascularization of the implantation site. We analyzed the effect of pore size on the…”
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In vitro induction of alkaline phosphatase levels predicts in vivo bone forming capacity of human bone marrow stromal cells by Prins, Henk-Jan, Braat, A. Koen, Gawlitta, D., Dhert, Wouter J.A., Egan, David A., Tijssen-Slump, Estel, Yuan, Huipin, Coffer, Paul J., Rozemuller, Henk, Martens, Anton C.

“…One of the applications of bone marrow stromal cells (BMSCs) that are produced by ex vivo expansion is for use in in vivo bone tissue engineering. Cultured…”
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In vitro and in vivo bioactivity assessment of a polylactic acid/hydroxyapatite composite for bone regeneration by Danoux, Charlène B, Barbieri, Davide, Yuan, Huipin, de Bruijn, Joost D, van Blitterswijk, Clemens A, Habibovic, Pamela

“…Synthetic bone graft substitutes based on composites consisting of a polymer and a calcium-phosphate (CaP) ceramic are developed with the aim to satisfy both…”
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Molecular mechanisms of biomaterial-driven osteogenic differentiation in human mesenchymal stromal cells by Barradas, Ana M C, Monticone, Veronica, Hulsman, Marc, Danoux, Charlène, Fernandes, Hugo, Tahmasebi Birgani, Zeinab, Barrère-de Groot, Florence, Yuan, Huipin, Reinders, Marcel, Habibovic, Pamela, van Blitterswijk, Clemens, de Boer, Jan

“…Calcium phosphate (CaP) based ceramics are used as bone graft substitutes in the treatment of bone defects. The physico-chemical properties of these materials…”
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Reconstructing the human hematopoietic niche in immunodeficient mice: opportunities for studying primary multiple myeloma by Groen, Richard W.J., Noort, Willy A., Raymakers, Reinier A., Prins, Henk-Jan, Aalders, Linda, Hofhuis, Frans M., Moerer, Petra, van Velzen, Jeroen F., Bloem, Andries C., van Kessel, Berris, Rozemuller, Henk, van Binsbergen, Ellen, Buijs, Arjan, Yuan, Huipin, de Bruijn, Joost D., de Weers, Michel, Parren, Paul W.H.I., Schuringa, Jan Jacob, Lokhorst, Henk M., Mutis, Tuna, Martens, Anton C.M.

“…Interactions within the hematopoietic niche in the BM microenvironment are essential for maintenance of the stem cell pool. In addition, this niche is thought…”
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Hypoxia Drives Material‐Induced Heterotopic Bone Formation by Enhancing Osteoclastogenesis via M2/Lipid‐Loaded Macrophage Axis by Li, Dan, Jiang, Yucan, He, Ping, Li, Yeming, Wu, Yan, Lei, Wei, Liu, Nanxin, Bruijn, Joost D., Zhang, Hua, Zhang, Hongmei, Ji, Ping, Yuan, Huipin, Li, Mingzheng

“…Heterotopic ossification (HO) is a double‐edged sword. Pathological HO presents as an undesired clinical complication, whereas controlled heterotopic bone…”
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Accessory Cells of the Microenvironment Protect Multiple Myeloma from T-Cell Cytotoxicity through Cell Adhesion-Mediated Immune Resistance by DE HAART, Sanne J, VAN DE DONK, Niels W. C. J, LOKHORST, Henk M, MARTENS, Anton C, MITSIADES, Constantine S, MUTIS, Tuna, MINNEMA, Monique C, HUANG, Julie H, AARTS-RIEMENS, Tineke, BOVENSCHEN, Niels, HUIPIN YUAN, GROEN, Richard W. J, MCMILLIN, Douglas W, JAKUBIKOVA, Jana

“…Cellular immunotherapy frequently fails to induce sustained remissions in patients with multiple myeloma, indicating the ability of multiple myeloma cells to…”
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Preclinical evidence for an effective therapeutic activity of FL118, a novel survivin inhibitor, in patients with relapsed/refractory multiple myeloma by Holthof, Lisa C, van der Horst, Hilma J, van Hal-van Veen, Susan E, Ruiter, Ruud W J, Li, Fengzhi, Buijze, Marijke, Andersen, Morten N, Yuan, Huipin, de Bruijn, Joost, van de Donk, Niels W C J, Lokhorst, Henk M, Zweegman, Sonja, Groen, Richard W J, Mutis, Tuna

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