Search Results - "Yuan, Hebao"

The peptide PROTAC modality: a novel strategy for targeted protein ubiquitination by Jin, Jinmei, Wu, Ye, Chen, Jinjiao, Shen, Yiwen, Zhang, Lijun, Zhang, Hong, Chen, Lili, Yuan, Hebao, Chen, Hongzhuan, Zhang, Weidong, Luan, Xin

“…Despite dramatic advances in drug discovery over the decades, effective therapeutic strategies for cancers treatment are still in urgent demands. PROteolysis…”
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Engineering exosomes as refined biological nanoplatforms for drug delivery by Luan, Xin, Sansanaphongpricha, Kanokwan, Myers, Ila, Chen, Hongwei, Yuan, Hebao, Sun, Duxin

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Suppression of autophagy by FIP200 deletion leads to osteopenia in mice through the inhibition of osteoblast terminal differentiation by Liu, Fei, Fang, Fang, Yuan, Hebao, Yang, Dongye, Chen, Yongqiang, Williams, Linford, Goldstein, Steven A, Krebsbach, Paul H, Guan, Jun‐Lin

“…ABSTRACT Autophagy is a conserved lysosomal degradation process that has important roles in both normal human physiology and disease. However, the function of…”
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Distinct biodistribution of doxorubicin and the altered dispositions mediated by different liposomal formulations by Luo, Ruijuan, Li, Yan, He, Miao, Zhang, Huixia, Yuan, Hebao, Johnson, Mark, Palmisano, Maria, Zhou, Simon, Sun, Duxin

“…Driving force for tissue distribution of doxorubicin solution (blue), Doxil (red) and Myocet (green) was distinct among three formulations. The difference in…”
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FAK Promotes Osteoblast Progenitor Cell Proliferation and Differentiation by Enhancing Wnt Signaling by Sun, Chunhui, Yuan, Hebao, Wang, Li, Wei, Xiaoxi, Williams, Linford, Krebsbach, Paul H, Guan, Jun‐Lin, Liu, Fei

“…ABSTRACT Decreased bone formation is often associated with increased bone marrow adiposity. The molecular mechanisms that are accountable for the negative…”
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Author Correction: Litchi seed extracts diminish prostate cancer progression via induction of apoptosis and attenuation of EMT through Akt/GSK-3β signaling by Guo, Hongwei, Luo, Hua, Yuan, Hebao, Xia, Yudui, Shu, Pan, Huang, Xin, Lu, Yi, Liu, Xia, Keller, Evan T., Sun, Duxin, Deng, Jiagang, Zhang, Jian

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E-cadherin is required for centrosome and spindle orientation in Drosophila male germline stem cells by Inaba, Mayu, Yuan, Hebao, Salzmann, Viktoria, Fuller, Margaret T, Yamashita, Yukiko M

“…Many adult stem cells reside in a special microenvironment known as the niche, where they receive essential signals that specify stem cell identity. Cell-cell…”
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Role of GRASP65 in Golgi Cisternal Stacking and Cell Cycle Progression by Tang, Danming, Yuan, Hebao, Wang, Yanzhuang

“…In vitro assays identified the Golgi peripheral protein GRASP65 as a Golgi stacking factor that links adjacent Golgi cisternae by forming mitotically regulated…”
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Regulation of cyclin A localization downstream of Par-1 function is critical for the centrosome orientation checkpoint in Drosophila male germline stem cells by Yuan, Hebao, Chiang, C.-Y. Ason, Cheng, Jun, Salzmann, Viktoria, Yamashita, Yukiko M.

“…Male germline stem cells (GSCs) in Drosophila melanogaster divide asymmetrically by orienting the mitotic spindle with respect to the niche, a microenvironment…”
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Structure‒tissue exposure/selectivity relationship (STR) correlates with clinical efficacy/safety by Gao, Wei, Hu, Hongxiang, Dai, Lipeng, He, Miao, Yuan, Hebao, Zhang, Huixia, Liao, Jinhui, Wen, Bo, Li, Yan, Palmisano, Maria, Traore, Mohamed Dit Mady, Zhou, Simon, Sun, Duxin

“…Drug optimization, which improves drug potency/specificity by structure‒activity relationship (SAR) and drug-like properties, is rigorously performed to select…”
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CPA4 is a Novel Diagnostic and Prognostic Marker for Human Non-Small-Cell Lung Cancer by Sun, Lichao, Wang, Yipeng, Yuan, Hebao, Burnett, Joseph, Pan, Jian, Yang, Zhihua, Ran, Yuliang, Myers, Ila, Sun, Duxin

“…Background. Carboxypeptidase A4 (CPA4) belongs to a member of the metallocarboxypeptidase family, and its expression in lung cancer samples and clinical…”
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Sequential phosphorylation of GRASP65 during mitotic Golgi disassembly by Tang, Danming, Yuan, Hebao, Vielemeyer, Ole, Perez, Franck, Wang, Yanzhuang

“…GRASP65 phosphorylation during mitosis and dephosphorylation after mitosis are required for Golgi disassembly and reassembly during the cell cycle. At least…”
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The Retention Factor p11 Confers an Endoplasmic Reticulum‐Localization Signal to the Potassium Channel TASK‐1 by Renigunta, Vijay, Yuan, Hebao, Zuzarte, Marylou, Rinné, Susanne, Koch, Annett, Wischmeyer, Erhard, Schlichthörl, Günter, Gao, Yadong, Karschin, Andreas, Jacob, Ralf, Schwappach, Blanche, Daut, Jürgen, Preisig‐Müller, Regina

“…The interaction of the adaptor protein p11, also denoted S100A10, with the C‐terminus of the two‐pore‐domain K+ channel TASK‐1 was studied using yeast…”
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Direct Selection of Monoclonal Phosphospecific Antibodies without Prior Phosphoamino Acid Mapping by Vielemeyer, Ole, Yuan, Hebao, Moutel, Sandrine, Saint-Fort, Rénette, Tang, Danming, Nizak, Clément, Goud, Bruno, Wang, Yanzhuang, Perez, Franck

“…In the current post-genomic era, large scale efforts are underway to functionally explore the proteome by assembling large antibody libraries. However, because…”
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Engineering exosomes as refined biological nanoplatforms for drug delivery by Luan, Xin, Sansanaphongpricha, Kanokwan, Myers, Ila, Chen, Hongwei, Yuan, Hebao, Sun, Duxin

“…Exosomes, a subgroup of extracellular vesicles (EVs), have been recognized as important mediators of long distance intercellular communication and are involved…”
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Albumin Nanoparticle of Paclitaxel (Abraxane) Decreases while Taxol Increases Breast Cancer Stem Cells in Treatment of Triple Negative Breast Cancer by Yuan, Hebao, Guo, Hongwei, Luan, Xin, He, Miao, Li, Feng, Burnett, Joseph, Truchan, Nathan, Sun, Duxin

“…Triple-negative breast cancer (TNBC) has a high rate of metastasis, which is associated with breast cancer stem-like cells (CSCs). Although Taxol (micelle…”
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Hide and run by Michelsen, Kai, Yuan, Hebao, Schwappach, Blanche

“…Arginine‐based endoplasmic reticulum (ER)‐localization signals are sorting motifs that are involved in the biosynthetic transport of multimeric membrane…”
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Tsc1 Regulates the Balance Between Osteoblast and Adipocyte Differentiation Through Autophagy/Notch1/β‐Catenin Cascade by Choi, Han Kyoung, Yuan, Hebao, Fang, Fang, Wei, Xiaoxi, Liu, Lu, Li, Qing, Guan, Jun‐Lin, Liu, Fei

“…ABSTRACT A reduction in trabecular bone mass is often associated with an increase in marrow fat in osteoporotic bones. The molecular mechanisms underlying this…”
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Mena-GRASP65 interaction couples actin polymerization to Golgi ribbon linking by Tang, Danming, Zhang, Xiaoyan, Huang, Shijiao, Yuan, Hebao, Li, Jie, Wang, Yanzhuang

“…In mammalian cells, the Golgi reassembly stacking protein 65 (GRASP65) has been implicated in both Golgi stacking and ribbon linking by forming trans-oligomers…”
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Abstract 4604: Long noncoding RNA Linc00162, as a novel prognostic marker, modulates cancer stem cell properties in triple-negative breast cancer by Sun, Lichao, Lin, ChangChing, Burnett, Joseph, Yuan, Hebao, Sun, Duxin

“…Abstract Trastuzumab is an effective treatment for HER2+ breast cancer. However, trastuzumab resistance in HER2+ breast cancer may induce the…”
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