Search Results - "Yu-Ju Chen"

Advances in data-independent acquisition mass spectrometry towards comprehensive digital proteome landscape by Kitata, Reta Birhanu, Yang, Jhih-Ci, Chen, Yu-Ju

“…The data-independent acquisition mass spectrometry (DIA-MS) has rapidly evolved as a powerful alternative for highly reproducible proteome profiling with a…”
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Streamlined single-cell proteomics by an integrated microfluidic chip and data-independent acquisition mass spectrometry by Gebreyesus, Sofani Tafesse, Siyal, Asad Ali, Kitata, Reta Birhanu, Chen, Eric Sheng-Wen, Enkhbayar, Bayarmaa, Angata, Takashi, Lin, Kuo-I, Chen, Yu-Ju, Tu, Hsiung-Lin

“…Single-cell proteomics can reveal cellular phenotypic heterogeneity and cell-specific functional networks underlying biological processes. Here, we present a…”
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Dynamic Association between Phonemic Awareness and Disordered Speech Recognition Moderated by Transcription Training by Chen, Yu-Ju, Yeh, Lili

“…Background: Phonetic transcription of disordered speech samples is especially crucial for the assessment and treatment of functional or organic speech-sound…”
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Cancer-associated fibroblasts regulate the plasticity of lung cancer stemness via paracrine signalling by Chen, Wan-Jiun, Ho, Chao-Chi, Chang, Yih-Leong, Chen, Hsuan-Yu, Lin, Chih-An, Ling, Thai-Yen, Yu, Sung-Liang, Yuan, Shin-Sheng, Louisa Chen, Yu-Ju, Lin, Chien-Yu, Pan, Szu-Hua, Elizabeth Chou, Han-Yi, Chen, Yu-Ju, Chang, Gee-Chen, Chu, Wen-Cheng, Lee, Yee-Ming, Lee, Jen-Yi, Lee, Pei-Jung, Li, Ker-Chau, Chen, Huei-Wen, Yang, Pan-Chyr

“…Cancer stem cells (CSCs) are a promising target for treating cancer, yet how CSC plasticity is maintained in vivo is unclear and is difficult to study in vitro…”
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A data-independent acquisition-based global phosphoproteomics system enables deep profiling by Kitata, Reta Birhanu, Choong, Wai-Kok, Tsai, Chia-Feng, Lin, Pei-Yi, Chen, Bo-Shiun, Chang, Yun-Chien, Nesvizhskii, Alexey I., Sung, Ting-Yi, Chen, Yu-Ju

“…Phosphoproteomics can provide insights into cellular signaling dynamics. To achieve deep and robust quantitative phosphoproteomics profiling for minute amounts…”
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Kinase Sensing Based on Protein Interactions at the Catalytic Site by Solomon, Ohad, Sapir, Hannah, Mervinetsky, Evgeniy, Chen, Yu‐Ju, Friedler, Assaf, Yitzchaik, Shlomo

“…The role kinases play in regulating cellular processes makes them potential biomarkers for detecting the onset and prognosis of various diseases, including…”
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Kinase Sensing Based on Protein Interactions at the Catalytic Site by Solomon, Ohad, Sapir, Hannah, Mervinetsky, Evgeniy, Chen, Yu‐Ju, Friedler, Assaf, Yitzchaik, Shlomo

“…Invited for the cover of this issue is Assaf Friedler, Shlomo Yitzchaik and co‐workers at the Hebrew University of Jerusalem and the Academia Sinica. The image…”
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Assessing the Benefits of Specific Attenuation for Quantitative Precipitation Estimation with a C-Band Radar Network by Cen, Ju-Yu, Trömel, Silke, Ryzhkov, Alexander, Simmer, Clemens

“…Recent advances demonstrate the benefits of radar-derived specific attenuation at horizontal polarization (A H) for quantitative precipitation estimation (QPE)…”
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Pharmacodynamic and therapeutic investigation of focused ultrasound-induced blood-brain barrier opening for enhanced temozolomide delivery in glioma treatment by Liu, Hao-Li, Huang, Chiung-Yin, Chen, Ju-Yu, Wang, Hay-Yan Jack, Chen, Pin-Yuan, Wei, Kuo-Chen

“…Focused ultrasound (FUS) exposure with the presence of microbubbles has been shown to transiently open the blood-brain barrier (BBB), and thus has potential to…”
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High Glucose Triggers Nucleotide Imbalance through O-GlcNAcylation of Key Enzymes and Induces KRAS Mutation in Pancreatic Cells by Hu, Chun-Mei, Tien, Sui-Chih, Hsieh, Ping-Kun, Jeng, Yung-Ming, Chang, Ming-Chu, Chang, Yu-Ting, Chen, Yi-Ju, Chen, Yu-Ju, Lee, Eva Y.-H.P., Lee, Wen-Hwa

“…KRAS mutations are the earliest events found in approximately 90% of pancreatic ductal adenocarcinomas (PDACs). However, little is known as to why KRAS…”
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Untargeted, spectral library-free analysis of data-independent acquisition proteomics data generated using Orbitrap mass spectrometers by Tsou, Chih-Chiang, Tsai, Chia-Feng, Teo, Guo Ci, Chen, Yu-Ju, Nesvizhskii, Alexey I.

“…We describe an improved version of the data‐independent acquisition (DIA) computational analysis tool DIA‐Umpire, and show that it enables highly sensitive,…”
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Hybrid-DIA: intelligent data acquisition integrates targeted and discovery proteomics to analyze phospho-signaling in single spheroids by Martínez-Val, Ana, Fort, Kyle, Koenig, Claire, Van der Hoeven, Leander, Franciosa, Giulia, Moehring, Thomas, Ishihama, Yasushi, Chen, Yu-ju, Makarov, Alexander, Xuan, Yue, Olsen, Jesper V.

“…Achieving sufficient coverage of regulatory phosphorylation sites by mass spectrometry (MS)-based phosphoproteomics for signaling pathway reconstitution is…”
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High-Throughput Phenotyping Approach for Screening Major Carotenoids of Tomato by Handheld Raman Spectroscopy Using Chemometric Methods by Akpolat, Hacer, Barineau, Mark, Jackson, Keith A, Akpolat, Mehmet Z, Francis, David M, Chen, Yu-Ju, Rodriguez-Saona, Luis E

“…Our objective was to develop a rapid technique for the non-invasive profiling and quantification of major tomato carotenoids using handheld Raman spectroscopy…”
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GPER‐induced signaling is essential for the survival of breast cancer stem cells by Chan, Yu‐Tzu, Lai, Alan C.‐Y., Lin, Ruey‐Jen, Wang, Ya‐Hui, Wang, Yi‐Ting, Chang, Wen‐Wei, Wu, Hsin‐Yi, Lin, Yu‐Ju, Chang, Wen‐Ying, Wu, Jen‐Chine, Yu, Jyh‐Cherng, Chen, Yu‐Ju, Yu, Alice L.

“…G protein‐coupled estrogen receptor‐1 (GPER), a member of the G protein‐coupled receptor (GPCR) superfamily, mediates estrogen‐induced proliferation of normal…”
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Identification of Downstream Components of Ubiquitin-Conjugating Enzyme PHOSPHATE2 by Quantitative Membrane Proteomics in Arabidopsis Roots by Huang, Teng-Kuei, Han, Chia-Li, Lin, Shu-I, Chen, Yu-Ju, Tsai, Yi-Chuan, Chen, Yet-Ran, Chen, June-Wei, Lin, Wei-Yi, Chen, Pei-Mien, Liu, Tzu-Yin, Chen, Ying-Shin, Sun, Ching-Mei, Chiou, Tzyy-Jen

“…MicroRNA399-mediated regulation of the ubiquitin-conjugating enzyme UBC24/PHOSPHATE2 (PHO2) is crucial for Pi acquisition and translocation in plants. Because…”
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Regulation of miRNA Biogenesis and Histone Modification by K63-Polyubiquitinated DDX17 Controls Cancer Stem-like Features by Kao, Shih-Han, Cheng, Wei-Chung, Wang, Yi-Ting, Wu, Han-Tsang, Yeh, Han-Yu, Chen, Yu-Ju, Tsai, Ming-Hsui, Wu, Kou-Juey

“…Markers of cancer stemness predispose patients to tumor aggressiveness, drug and immunotherapy resistance, relapse, and metastasis. DDX17 is a cofactor of the…”
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Exosomes Derived from Hypoxia-Cultured Human Adipose Stem Cells Alleviate Articular Chondrocyte Inflammaging and Post-Traumatic Osteoarthritis Progression by Chang, Ling-Hua, Wu, Shun-Cheng, Chen, Chung-Hwan, Chen, Jhen-Wei, Huang, Wan-Chun, Wu, Che-Wei, Lin, Yi-Shan, Chen, Yu-Ju, Chang, Je-Ken, Ho, Mei-Ling

“…Osteoarthritis (OA) is the most common age-related degenerative joint disease. Inflammaging, linking inflammation and aging, is found in senescent cells with…”
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Large-scale determination of absolute phosphorylation stoichiometries in human cells by motif-targeting quantitative proteomics by Tsai, Chia-Feng, Wang, Yi-Ting, Yen, Hsin-Yung, Tsou, Chih-Chiang, Ku, Wei-Chi, Lin, Pei-Yi, Chen, Hsuan-Yu, Nesvizhskii, Alexey I., Ishihama, Yasushi, Chen, Yu-Ju

“…Our ability to model the dynamics of signal transduction networks will depend on accurate methods to quantify levels of protein phosphorylation on a global…”
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K63-polyubiquitinated HAUSP deubiquitinates HIF-1α and dictates H3K56 acetylation promoting hypoxia-induced tumour progression by Wu, Han-Tsang, Kuo, Yi-Chih, Hung, Jung-Jyh, Huang, Chi-Hung, Chen, Wei-Yi, Chou, Teh-Ying, Chen, Yeh, Chen, Yi-Ju, Chen, Yu-Ju, Cheng, Wei-Chung, Teng, Shu-Chun, Wu, Kou-Juey

“…Intratumoural hypoxia induces HIF-1α and promotes tumour progression, metastasis and treatment resistance. HIF-1α stability is regulated by VHL-E3…”
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Effect of sialylation on EGFR phosphorylation and resistance to tyrosine kinase inhibition by Yen, Hsin-Yung, Liu, Ying-Chih, Chen, Nai-Yu, Tsai, Chia-Feng, Wang, Yi-Ting, Chen, Yu-Ju, Hsu, Tsui-Ling, Yang, Pan-Chyr, Wong, Chi-Huey

“…Epidermal growth factor receptor (EGFR) is a heavily glycosylated transmembrane receptor tyrosine kinase. Upon EGF-binding, EGFR undergoes conformational…”
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