Search Results - "Yu, Xuekui"

Structural basis for genome packaging, retention, and ejection in human cytomegalovirus by Li, Zhihai, Pang, Jingjing, Dong, Lili, Yu, Xuekui

“…How the human cytomegalovirus (HCMV) genome—the largest among human herpesviruses—is packaged, retained, and ejected remains unclear. We present the in situ…”
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Cryo-EM structure of human heptameric Pannexin 1 channel by Qu, Ronggui, Dong, Lili, Zhang, Jilin, Yu, Xuekui, Wang, Lei, Zhu, Shujia

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Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin by Yin, Wanchao, Luan, Xiaodong, Li, Zhihai, Zhou, Ziwei, Wang, Qingxing, Gao, Minqi, Wang, Xiaoxi, Zhou, Fulai, Shi, Jingjing, You, Erli, Liu, Mingliang, Wang, Qingxia, Jiang, Yi, Jiang, Hualiang, Xiao, Gengfu, Zhang, Leike, Yu, Xuekui, Zhang, Shuyang, Eric Xu, H.

“…The COVID-19 pandemic caused by nonstop infections of SARS-CoV-2 has continued to ravage many countries worldwide. Here we report that suramin, a 100-year-old…”
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Progress towards revealing the mechanism of herpesvirus capsid maturation and genome packaging by Li, Zhihai, Yu, Xuekui

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Atomic structures of a bactericidal contractile nanotube in its pre- and postcontraction states by Ge, Peng, Scholl, Dean, Leiman, Petr G, Yu, Xuekui, Miller, Jeff F, Zhou, Z Hong

“…Cryo-EM structures of the pre- and postcontraction states of Pseudomonas aeruginosa R-type pyocins provide details of the conformational changes between the…”
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Cryo-EM structure of the mature dengue virus at 3.5-Å resolution by Zhang, Xiaokang, Ge, Peng, Yu, Xuekui, Brannan, Jennifer M, Bi, Guoqiang, Zhang, Qinfen, Schein, Stan, Zhou, Z Hong

“…Dengue virus has two membrane proteins, E and M, which undergo dramatic structural changes during the life cycle of the virus. The 3.5-Å cryo-EM structure of…”
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3.88 Å structure of cytoplasmic polyhedrosis virus by cryo-electron microscopy by Zhou, Z. Hong, Yu, Xuekui, Jin, Lei

“…Cytoplasmic polyhedrosis virus (CPV) is unique within the Reoviridae family in having a turreted single-layer capsid contained within polyhedrin inclusion…”
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GPCRs steer Gi and Gs selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors by Huang, Sijie, Xu, Peiyu, Shen, Dan-Dan, Simon, Icaro A., Mao, Chunyou, Tan, Yangxia, Zhang, Huibing, Harpsøe, Kasper, Li, Huadong, Zhang, Yumu, You, Chongzhao, Yu, Xuekui, Jiang, Yi, Zhang, Yan, Gloriam, David E., Xu, H. Eric

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In situ structures of the segmented genome and RNA polymerase complex inside a dsRNA virus by Zhang, Xing, Ding, Ke, Yu, Xuekui, Chang, Winston, Sun, Jingchen, Hong Zhou, Z.

“…This study visualizes the interior of a dsRNA virus using cryo-electron microscopy, revealing the organization of the genome of cytoplasmic polyhedrosis virus…”
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Cryo-electron microscopy structures of capsids and in situ portals of DNA-devoid capsids of human cytomegalovirus by Li, Zhihai, Pang, Jingjing, Gao, Rongchao, Wang, Qingxia, Zhang, Maoyan, Yu, Xuekui

“…The portal-scaffold complex is believed to nucleate the assembly of herpesvirus procapsids. During capsid maturation, two events occur: scaffold expulsion and…”
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3.5Å cryoEM structure of hepatitis B virus core assembled from full-length core protein by Yu, Xuekui, Jin, Lei, Jih, Jonathan, Shih, Chiaho, Zhou, Z Hong

“…The capsid shell of infectious hepatitis B virus (HBV) is composed of 240 copies of a single protein called HBV core antigen (HBc). An atomic model of a core…”
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Different functional states of fusion protein gB revealed on human cytomegalovirus by cryo electron tomography with Volta phase plate by Si, Zhu, Zhang, Jiayan, Shivakoti, Sakar, Atanasov, Ivo, Tao, Chang-Lu, Hui, Wong H, Zhou, Kang, Yu, Xuekui, Li, Weike, Luo, Ming, Bi, Guo-Qiang, Zhou, Z Hong

“…Human cytomegalovirus (HCMV) enters host by glycoprotein B (gB)-mediated membrane fusion upon receptor-binding to gH/gL-related complexes, causing devastating…”
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Structures of the human dopamine D3 receptor-Gi complexes by Xu, Peiyu, Huang, Sijie, Mao, Chunyou, Krumm, Brian E., Zhou, X. Edward, Tan, Yangxia, Huang, Xi-Ping, Liu, Yongfeng, Shen, Dan-Dan, Jiang, Yi, Yu, Xuekui, Jiang, Hualiang, Melcher, Karsten, Roth, Bryan L., Cheng, Xi, Zhang, Yan, Xu, H. Eric

“…The dopamine system, including five dopamine receptors (D1R–D5R), plays essential roles in the central nervous system (CNS), and ligands that activate dopamine…”
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CryoEM structure of the tegumented capsid of Epstein-Barr virus by Li, Zhihai, Zhang, Xiao, Dong, Lili, Pang, Jingjing, Xu, Miao, Zhong, Qian, Zeng, Mu-Sheng, Yu, Xuekui

“…Epstein-Barr virus (EBV) is the primary cause of infectious mononucleosis and has been shown to be closely associated with various malignancies. Here, we…”
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Structural insights into the functional mechanism of the ubiquitin ligase E6AP by Wang, Zhen, Fan, Fengying, Li, Zhihai, Ye, Fei, Wang, Qingxia, Gao, Rongchao, Qiu, Jiaxuan, Lv, Yixin, Lin, Min, Xu, Wenwen, Luo, Cheng, Yu, Xuekui

“…E6AP dysfunction is associated with Angelman syndrome and Autism spectrum disorder. Additionally, the host E6AP is hijacked by the high-risk HPV E6 to…”
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A putative ATPase mediates RNA transcription and capping in a dsRNA virus by Yu, Xuekui, Jiang, Jiansen, Sun, Jingchen, Zhou, Z Hong

“…mRNA transcription in dsRNA viruses is a highly regulated process but the mechanism of this regulation is not known. Here, by nucleoside triphosphatase…”
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Atomic Structure of the E2 Inner Core of Human Pyruvate Dehydrogenase Complex by Jiang, Jiansen, Baiesc, Flavius L, Hiromasa, Yasuaki, Yu, Xuekui, Hui, Wong Hoi, Dai, Xinghong, Roche, Thomas E, Zhou, Z. Hong

“…Pyruvate dehydrogenase complex (PDC) is a large multienzyme complex that catalyzes the irreversible conversion of pyruvate to acetyl-coenzyme A with reduction…”
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Atomic structures and deletion mutant reveal different capsid-binding patterns and functional significance of tegument protein pp150 in murine and human cytomegaloviruses with implications for therapeutic development by Liu, Wei, Dai, Xinghong, Jih, Jonathan, Chan, Karen, Trang, Phong, Yu, Xuekui, Balogun, Rilwan, Mei, Ye, Liu, Fenyong, Zhou, Z Hong

“…Cytomegalovirus (CMV) infection causes birth defects and life-threatening complications in immunosuppressed patients. Lack of vaccine and need for more…”
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A complex structure of arrestin-2 bound to a G protein-coupled receptor by Yin, Wanchao, Li, Zhihai, Jin, Mingliang, Yin, Yu-Ling, de Waal, Parker W., Pal, Kuntal, Yin, Yanting, Gao, Xiang, He, Yuanzheng, Gao, Jing, Wang, Xiaoxi, Zhang, Yan, Zhou, Hu, Melcher, Karsten, Jiang, Yi, Cong, Yao, Edward Zhou, X., Yu, Xuekui, Eric Xu, H.

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The smallest capsid protein mediates binding of the essential tegument protein pp150 to stabilize DNA-containing capsids in human cytomegalovirus by Dai, Xinghong, Yu, Xuekui, Gong, Hao, Jiang, Xiaohong, Abenes, Gerrado, Liu, Hongrong, Shivakoti, Sakar, Britt, William J, Zhu, Hua, Liu, Fenyong, Zhou, Z Hong

“…Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus that causes birth defects in newborns and life-threatening complications in immunocompromised…”
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