Search Results - "Yu, Wenbao"

Identifying topologically associating domains and subdomains by Gaussian Mixture model And Proportion test by Yu, Wenbao, He, Bing, Tan, Kai

“…The spatial organization of the genome plays a critical role in regulating gene expression. Recent chromatin interaction mapping studies have revealed that…”
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scATAC-pro: a comprehensive workbench for single-cell chromatin accessibility sequencing data by Yu, Wenbao, Uzun, Yasin, Zhu, Qin, Chen, Changya, Tan, Kai

“…Single-cell chromatin accessibility sequencing has become a powerful technology for understanding epigenetic heterogeneity of complex tissues. However, there…”
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A unified model based multifactor dimensionality reduction framework for detecting gene-gene interactions by Yu, Wenbao, Lee, Seungyeoun, Park, Taesung

“…Gene-gene interaction (GGI) is one of the most popular approaches for finding and explaining the missing heritability of common complex traits in genome-wide…”
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Spatial Genome Re-organization between Fetal and Adult Hematopoietic Stem Cells by Chen, Changya, Yu, Wenbao, Tober, Joanna, Gao, Peng, He, Bing, Lee, Kiwon, Trieu, Tuan, Blobel, Gerd A., Speck, Nancy A., Tan, Kai

“…Fetal hematopoietic stem cells (HSCs) undergo a developmental switch to become adult HSCs with distinct functional properties. To better understand the…”
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Bistable switch in let-7 miRNA biogenesis pathway involving Lin28 by Shi, Fei, Yu, Wenbao, Wang, Xia

“…miRNAs are small noncoding RNAs capable of regulating gene expression at the post-transcriptional level. A growing body of evidence demonstrated that let-7…”
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Unified Cox model based multifactor dimensionality reduction method for gene-gene interaction analysis of the survival phenotype by Lee, Seungyeoun, Son, Donghee, Kim, Yongkang, Yu, Wenbao, Park, Taesung

“…One strategy for addressing missing heritability in genome-wide association study is gene-gene interaction analysis, which, unlike a single gene approach,…”
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Multivariate Quantitative Multifactor Dimensionality Reduction for Detecting Gene-Gene Interactions by Yu, Wenbao, Kwon, Min-Seok, Park, Taesung

“…To determine gene-gene interactions and missing heritability of complex diseases is a challenging topic in genome-wide association studies. The multifactor…”
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222-J Longitudinal spatial profiling of pediatric high-grade glioma reveals a heterogeneous and dynamic immune microenvironment with therapeutic implications by Zellmer, Abigail M, Sussman, Jonathan, Baxter, Amy E, Vanguri, Rami S, Ahn, Kyung Jin, Parvaresh-Rizi, Arianne, Thadi, Anusha, Chen, Chia-hui, Yu, Wenbao, Cole, Kristina, Tan, Kai, Oldridge, Derek A

“…BackgroundPediatric high-grade glioma (pHGG) is a deadly childhood cancer, with five-year survival under 20%. Conventional therapy consisting of radiation and,…”
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Gene-Gene Interaction Analysis for the Accelerated Failure Time Model Using a Unified Model-Based Multifactor Dimensionality Reduction Method by Lee, Seungyeoun, Son, Donghee, Yu, Wenbao, Park, Taesung

“…Although a large number of genetic variants have been identified to be associated with common diseases through genome-wide association studies, there still…”
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Gene-Gene Interaction Analysis for the Accelerated Failure Time Model Using a Unified Model-Based Multifactor Dimensionality Reduction Method by Lee, Seungyeoun, Son, Donghee, Yu, Wenbao, Park, Taesung

“…Although a large number of genetic variants have been identified to be associated with common diseases through genome-wide association studies, there still…”
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AucPR: an AUC-based approach using penalized regression for disease prediction with high-dimensional omics data by Yu, Wenbao, Park, Taesung

“…It is common to get an optimal combination of markers for disease classification and prediction when multiple markers are available. Many approaches based on…”
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Two simple algorithms on linear combination of multiple biomarkers to maximize partial area under the ROC curve by Yu, Wenbao, Park, Taesung

“…In clinical practices, it is common that several biomakers are related to a specific disease and each single marker does not have enough diagnostic power. An…”
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Developmental trajectory of prehematopoietic stem cell formation from endothelium by Zhu, Qin, Gao, Peng, Tober, Joanna, Bennett, Laura, Chen, Changya, Uzun, Yasin, Li, Yan, Howell, Elizabeth D., Mumau, Melanie, Yu, Wenbao, He, Bing, Speck, Nancy A., Tan, Kai

“…Hematopoietic stem and progenitor cells (HSPCs) in the bone marrow are derived from a small population of hemogenic endothelial (HE) cells located in the major…”
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ESTIMATION OF AREA UNDER THE ROC CURVE UNDER NONIGNORABLE VERIFICATION BIAS by Yu, Wenbao, Kim, Jae Kwang, Park, Taesung

“…The Area Under the Receiving Operating Characteristic Curve (AUC) is frequently used for assessing the overall accuracy of a diagnostic marker. However,…”
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Integrative Bulk and Single-Cell Profiling of Premanufacture T-cell Populations Reveals Factors Mediating Long-Term Persistence of CAR T-cell Therapy by Chen, Gregory M, Chen, Changya, Das, Rajat K, Gao, Peng, Chen, Chia-Hui, Bandyopadhyay, Shovik, Ding, Yang-Yang, Uzun, Yasin, Yu, Wenbao, Zhu, Qin, Myers, Regina M, Grupp, Stephan A, Barrett, David M, Tan, Kai

“…The adoptive transfer of chimeric antigen receptor (CAR) T cells represents a breakthrough in clinical oncology, yet both between- and within-patient…”
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Absence of biopolymers in surface waters inhibits flocs growth in winter: A secret of coagulation over decades by Su, Zhaoyang, Wu, Xiaoting, Yu, Wenbao, Liu, Ting, Li, Xing, Liu, Muyang, Yu, Wenzheng

“…Factors responsible for undesirable coagulation performance in winter have not been well understood by far. The aim of this work is to identify the critical…”
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The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution by Rood, Jennifer E., Coffey, Robert J., Demir, Emek, Ghosh, Sharmistha, Iacobuzio-Donahue, Christine A., Jané-Valbuena, Judit, Mazzilli, Sarah A., Pe’er, Dana, Tan, Kai, Aguilar, Ruben A., Babur, Ozgun, Boland, Genevieve, Bosse, Kristopher, Bott, Matthew, Boyden, Ed, Brooks, James, Cerami, Ethan, Chang, Young Hwan, Chaudhary, Ojasvi, Chen, Alyce A., Chen, Feng, Chun, Jaeyoung, Cisneros, Luis, Contrepois, Kevin, Creason, Allison L., Demir, Emek, Diskin, Sharon, Drewes, Julia, Eng, Jennifer, Erwin, Graham, Flaherty, Keith, Gao, Jianjiong, Gao, Vianne R., Giannakis, Marios, Gowers, Kate, Gray, Joe W., Greenleaf, William, Gresham, Jeremy, Hacohen, Nir, Harris, Kathleen A., Hayashi, Akimasa, Herndon, John M., Huh, Won Jae, Ijaz, Heba, Izar, Benjamin, Johnson, Brett E., Kaestner, Klaus, Kim, Albert H., Kopytra, Mateusz, Kundaje, Anshul, Lau, Ken S., Lee, Hayan, Lenburg, Marc, Lim, Kian-Huat, Lin, Yiyun, Lively, Tracy, Longabaugh, William J.R., Ma, Cynthia X., Marks, Jeffrey, Masilionais, Ignas, McKinley, Eliot T., McMichael, Joshua F., Mosse, Yael, Ness, Reid, Nikolov, Milen, Oberdoerffer, Philipp, Offin, Michael, Olson, Anastasiya, Ossandon, Miguel, Polyak, Kornelia, Reid, Mary, Roy, Sudipta, Ryser, Marc D., Schrag, Deborah, Sears, Rosalie C., Shalek, Alex, Sheng, Jeff, Shoghi, Kooresh I., Sibley, Alexander B., Sorger, Peter K., Southard-Smith, Austin, Srivastava, Sudhir, Storm, Phillip, Sullivan, Ryan, Suvà, Mario, Thorsson, Vésteinn, Tran, Linh, Veis, Deborah J., Vossough, Arastoo, Wagle, Nikhil, Wang, Liang-Bo, West, Robert, Wu, Chi-yun, Wyczalkowski, Matthew A., Xie, Yubin, Yang, Xiaolu, Zhang, Mianlei, Zhang, Yantian, Zhou, Daniel Cui, Zhuang, Xiaowei

“…Crucial transitions in cancer—including tumor initiation, local expansion, metastasis, and therapeutic resistance—involve complex interactions between cells…”
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Transcriptional Rewiring and Therapeutic Resistance in Philadelphia Chromosome-like Acute Lymphoblastic Leukemia by Ding, Yang Y, Loftus, Joseph Patrick, Mathier, Benjamin, Yu, Wenbao, Allen, David Hottman, He, Bing, Falkenstein, Catherine D, Tasian, Sarah K, Tan, Kai

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Single-cell multiomics reveals increased plasticity, resistant populations, and stem-cell–like blasts in KMT2A-rearranged leukemia by Chen, Changya, Yu, Wenbao, Alikarami, Fatemeh, Qiu, Qi, Chen, Chia-hui, Flournoy, Jennifer, Gao, Peng, Uzun, Yasin, Fang, Li, Davenport, James W., Hu, Yuxuan, Zhu, Qin, Wang, Kai, Libbrecht, Clara, Felmeister, Alex, Rozich, Isaiah, Ding, Yang-yang, Hunger, Stephen P., Felix, Carolyn A., Wu, Hao, Brown, Patrick A., Guest, Erin M., Barrett, David M., Bernt, Kathrin M., Tan, Kai

“…KMT2A-rearranged (KMT2A-r) infant acute lymphoblastic leukemia (ALL) is a devastating malignancy with a dismal outcome, and younger age at diagnosis is…”
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Estimation of Area Under the ROC Curve under nonignorable verication bias by Yu, Wenbao, Kim, Jae Kwang, Park, Taesung

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