Search Results - "Yu, Wanfeng"

Development of a clinical polygenic risk score assay and reporting workflow by Hao, Limin, Kraft, Peter, Berriz, Gabriel F., Hynes, Elizabeth D., Koch, Christopher, Korategere V Kumar, Prathik, Parpattedar, Shruti S., Steeves, Marcie, Yu, Wanfeng, Antwi, Ashley A., Brunette, Charles A., Danowski, Morgan, Gala, Manish K., Green, Robert C., Jones, Natalie E., Lewis, Anna C. F., Lubitz, Steven A., Natarajan, Pradeep, Vassy, Jason L., Lebo, Matthew S.

“…Implementation of polygenic risk scores (PRS) may improve disease prevention and management but poses several challenges: the construction of clinically valid…”
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H₂O₂ activates G protein, α 12 to disrupt the junctional complex and enhance ischemia reperfusion injury by Yu, Wanfeng, Beaudry, Sarah, Negoro, Hideyuki, Boucher, Ilene, Tran, Mei, Kong, Tianqing, Denker, Bradley M.

“…The epithelial cell tight junction separates apical and basolateral domains and is essential for barrier function. Disruption of the tight junction is a…”
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Gα12 activation in podocytes leads to cumulative changes in glomerular collagen expression, proteinuria and glomerulosclerosis by Boucher, Ilene, Yu, Wanfeng, Beaudry, Sarah, Negoro, Hideyuki, Tran, Mei, Pollak, Martin R, Henderson, Joel M, Denker, Bradley M

“…Glomerulosclerosis is a common pathological finding that often progresses to renal failure. The mechanisms of chronic kidney disease progression are not well…”
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Gα12 Inhibits α2β1 Integrin–mediated Madin-Darby Canine Kidney Cell Attachment and Migration on Collagen-I and Blocks Tubulogenesis by Kong, Tianqing, Xu, Daosong, Yu, Wanfeng, Takakura, Ayumi, Boucher, Ilene, Tran, Mei, Kreidberg, Jordan A., Shah, Jagesh, Zhou, Jing, Denker, Bradley M.

“…Regulation of epithelial cell attachment and migration are essential for normal development and maintenance of numerous tissues. G proteins and integrins are…”
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Mutations in the TΨC Loop of E. coli tRNALys,3 Have Varied Effects on In Trans Complementation of HIV-1 Replication by Yu, Wanfeng, McCulley, Anna, Morrow, Casey D

“…Abstract Background Human immunodeficiency virus (HIV-1) exclusively selects and utilizes tRNA Lys,3 as the primer for initiation of reverse transcription…”
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Cowden syndrome-associated germline SDHD variants alter PTEN nuclear translocation through SRC-induced PTEN oxidation by Yu, Wanfeng, He, Xin, Ni, Ying, Ngeow, Joanne, Eng, Charis

“…Germline mutations in the PTEN tumor-suppressor gene and germline variations in succinate dehydrogenase subunit D gene (SDHD-G12S, SDHD-H50R) are associated…”
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Cowden syndrome-associated germline succinate dehydrogenase complex subunit D (SDHD) variants cause PTEN-mediated down-regulation of autophagy in thyroid cancer cells by Yu, Wanfeng, Ni, Ying, Saji, Motoyasu, Ringel, Matthew D, Jaini, Ritika, Eng, Charis

“…Thyroid cancer is a major component cancer of Cowden syndrome (CS), a disorder typically associated with germline mutations in PTEN. Germline variants in…”
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Abstract 1706: High-quality whole-genome sequencing and analysis of FFPE samples from multiplecancer types by Bailey, Shannon T., Lund, James, Ekram, Muhammad, Yu, Wanfeng, Williams, Richard T., Sun, Hongye, Gulcher, Jeffrey R.

“…Abstract Next-generation sequencing analysis of formalin-fixed, paraffin-embedded (FFPE) samples has the potential to lead to major advances in cancer…”
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Development of a clinical assay for reporting polygenic risk scores by Lebo, Matthew, Hao, Limin, Berriz, Gabriel, Danowski, Morgan, Koch, Christopher, Kumar, Prathik Korategere, Lewis, Anna, Parpattedar, Shruti, Steeves, Marcie, Yu, Wanfeng, Kraft, Peter, Vassy, Jason

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OP338 - Development of a clinical assay for reporting polygenic risk scores by Lebo, Matthew, Hao, Limin, Berriz, Gabriel, Danowski, Morgan, Koch, Christopher, Kumar, Prathik Korategere, Lewis, Anna, Parpattedar, Shruti, Steeves, Marcie, Yu, Wanfeng, Kraft, Peter, Vassy, Jason

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Exome Sequencing Reveals Germline SMAD9 Mutation That Reduces Phosphatase and Tensin Homolog Expression and Is Associated With Hamartomatous Polyposis and Gastrointestinal Ganglioneuromas by Ngeow, Joanne, Yu, Wanfeng, Yehia, Lamis, Niazi, Farshad, Chen, Jinlian, Tang, Xuhua, Heald, Brandie, Lei, Junying, Romigh, Todd, Tucker-Kellogg, Lisa, Lim, Kiat Hon, Song, Haiwei, Eng, Charis

“…Hamartomatous polyposis syndromes (HPS) account for a small but appreciable proportion of inherited gastrointestinal cancer predisposition syndromes; patients…”
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Germline disruption of Pten localization causes enhanced sex-dependent social motivation and increased glial production by Tilot, Amanda K, Gaugler, Mary K, Yu, Qi, Romigh, Todd, Yu, Wanfeng, Miller, Robert H, Frazier, 2nd, Thomas W, Eng, Charis

“…PTEN Hamartoma Tumor Syndrome (PHTS) is an autosomal-dominant genetic condition underlying a subset of autism spectrum disorder (ASD) with macrocephaly. Caused…”
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Reanalysis of eMERGE phase III sequence variants in 10,500 participants and infrastructure to support the automated return of knowledge updates by Zouk, Hana, Yu, Wanfeng, Oza, Andrea, Hawley, Megan, Vijay Kumar, Prathik K., Koch, Christopher, Mahanta, Lisa M., Harley, John B., Jarvik, Gail P., Karlson, Elizabeth W., Leppig, Kathleen A., Myers, Melanie F., Prows, Cynthia A., Williams, Marc S., Weiss, Scott T., Lebo, Matthew S., Rehm, Heidi L.

“…The clinical genomics knowledgebase is dynamic with variant classifications changing as newly identified cases, additional population data, and other evidence…”
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Dietary Selenium Requirement of Golden Pompano(Trachinotus ovatus) by Yu, Wanfeng

“…To determine the optimal dietary selenium requirement of golden pompano(Trachinotus ovatus),a total of 450 fish with an initial body weight of(15.04±0.20)g…”
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Gα12 is required for renal cystogenesis induced by Pkd1 inactivation by Wu, Yong, Xu, Jen X, El-Jouni, Wassim, Lu, Tzongshi, Li, Suyan, Wang, Qingyi, Tran, Mei, Yu, Wanfeng, Wu, Maoqing, Barrera, Ivan E, Bonventre, Joseph V, Zhou, Jing, Denker, Bradley M, Kong, Tianqing

“…Mutation of PKD1, encoding the protein polycystin-1 (PC1), is the main cause of autosomal dominant polycystic kidney disease (ADPKD). The signaling pathways…”
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H^sub 2^O^sub 2^ activates G protein, [alpha] 12 to disrupt the junctional complex and enhance ischemia reperfusion injury by Yu, Wanfeng, Beaudry, Sarah, Negoro, Hideyuki, Boucher, Ilene, Tran, Mei, Kong, Tianqing, Denker, Bradley M

“…The epithelial cell tight junction separates apical and basolateral domains and is essential for barrier function. Disruption of the tight junction is a…”
Get full text

H 2 O 2 activates G protein, α 12 to disrupt the junctional complex and enhance ischemia reperfusion injury by Yu, Wanfeng, Beaudry, Sarah, Negoro, Hideyuki, Boucher, Ilene, Tran, Mei, Kong, Tianqing, Denker, Bradley M.

“…The epithelial cell tight junction separates apical and basolateral domains and is essential for barrier function. Disruption of the tight junction is a…”
Get full text

Identification of polycystin-1 and Gα12 binding regions necessary for regulation of apoptosis by Yu, Wanfeng, Ritchie, Benjamin J., Su, Xuefeng, Zhou, Jing, Meigs, Thomas E., Denker, Bradley M.

“…Most patients with autosomal dominant polycystic kidney disease (ADPKD) harbor mutations in PKD1, the gene for polycystin-1 (PC1), a transmembrane protein with…”
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G[alpha]12 activation in podocytes leads to cumulative changes in glomerular collagen expression, proteinuria and glomerulosclerosis by Boucher, Ilene, Yu, Wanfeng, Beaudry, Sarah, Negoro, Hideyuki, Tran, Mei, Pollak, Martin R, Henderson, Joel M, Denker, Bradley M

“…Glomerulosclerosis is a common pathological finding that often progresses to renal failure. The mechanisms of chronic kidney disease progression are not well…”
Get full text

Identification of polycystin-1 and Ga12 binding regions necessary for regulation of apoptosis by Yu, Wanfeng, Ritchie, Benjamin J, Su, Xuefeng, Zhou, Jing, Meigs, Thomas E, Denker, Bradley M

“…Most patients with autosomal dominant polycystic kidney disease (ADPKD) harbor mutations in PKD1, the gene for polycystin-1 (PC1), a transmembrane protein with…”
Get full text